Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea

A nationwide retrospective study

S. J. Yun, O. S. Kwon, J. H. Han, S. S. Kweon, M. W. Lee, D. Y. Lee, M. B. Kim, Y. C. Kim, T. Y. Yoon, K. Y. Chung, Il-Hwan Kim, K. H. Kim, K. S. Suh, S. J. Lee, Y. J. Seo, K. H. Kim, H. J. Park, M. R. Roh, K. J. Ahn, T. J. Yoon & 10 others M. H. Kim, K. S. Li, J. S. Park, B. S. Shin, J. Y. Ko, Hyo Hyun Ahn, H. J. Kim, S. D. Park, S. J. Jang, Y. H. Won

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background Giant congenital melanocytic naevi (GCMN) are known risk factors for the development of melanoma. However, melanoma risk among Asians is rarely evaluated. Objectives To evaluate the clinical characteristics and risk of melanoma development from GCMN in Koreans, we performed a nationwide retrospective cohort study in Korea. GCMN were defined as those comprising ≥ 5% body surface area in children or measuring ≥ 20 cm in adults. Methods In total, 131 patients with GCMN were enrolled, with a mean age of 10·3 years (range: birth-70 years). Results The posterior trunk was the most common site (67, 51·1%), followed by lateral trunk, anterior trunk, legs, both anterior and posterior trunk, buttocks, and arms. Satellite naevi were present in 69 cases (52·7%), and axial areas were more commonly involved in patients with satellite naevi than in those without satellite lesions. Atypical features such as rete ridge elongation and bridges were seen, and, among these, pagetoid spread and ballooning cell changes were more common in patients < 4 years old. Proliferative nodules were found in three cases. Melanomas had developed in three of 131 patients (2·3%; a 6-year-old girl, a 14-year-old girl and a 70-year-old man), and the incidence rate was 990 per 100 000 person-years. Melanomas in these three patients consisted of two cutaneous melanomas and one extracutaneous meningeal melanoma. Conclusions We should be aware of melanoma development from GCMN, and lifelong follow-up is required due to the risk of melanoma arising in GCMN.

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalBritish Journal of Dermatology
Volume166
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Pigmented Nevus
Korea
Melanoma
Retrospective Studies
Nevus
Buttocks
Body Surface Area
Leg
Arm
Cohort Studies
Parturition
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea : A nationwide retrospective study. / Yun, S. J.; Kwon, O. S.; Han, J. H.; Kweon, S. S.; Lee, M. W.; Lee, D. Y.; Kim, M. B.; Kim, Y. C.; Yoon, T. Y.; Chung, K. Y.; Kim, Il-Hwan; Kim, K. H.; Suh, K. S.; Lee, S. J.; Seo, Y. J.; Kim, K. H.; Park, H. J.; Roh, M. R.; Ahn, K. J.; Yoon, T. J.; Kim, M. H.; Li, K. S.; Park, J. S.; Shin, B. S.; Ko, J. Y.; Ahn, Hyo Hyun; Kim, H. J.; Park, S. D.; Jang, S. J.; Won, Y. H.

In: British Journal of Dermatology, Vol. 166, No. 1, 01.01.2012, p. 115-123.

Research output: Contribution to journalArticle

Yun, SJ, Kwon, OS, Han, JH, Kweon, SS, Lee, MW, Lee, DY, Kim, MB, Kim, YC, Yoon, TY, Chung, KY, Kim, I-H, Kim, KH, Suh, KS, Lee, SJ, Seo, YJ, Kim, KH, Park, HJ, Roh, MR, Ahn, KJ, Yoon, TJ, Kim, MH, Li, KS, Park, JS, Shin, BS, Ko, JY, Ahn, HH, Kim, HJ, Park, SD, Jang, SJ & Won, YH 2012, 'Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea: A nationwide retrospective study', British Journal of Dermatology, vol. 166, no. 1, pp. 115-123. https://doi.org/10.1111/j.1365-2133.2011.10636.x
Yun, S. J. ; Kwon, O. S. ; Han, J. H. ; Kweon, S. S. ; Lee, M. W. ; Lee, D. Y. ; Kim, M. B. ; Kim, Y. C. ; Yoon, T. Y. ; Chung, K. Y. ; Kim, Il-Hwan ; Kim, K. H. ; Suh, K. S. ; Lee, S. J. ; Seo, Y. J. ; Kim, K. H. ; Park, H. J. ; Roh, M. R. ; Ahn, K. J. ; Yoon, T. J. ; Kim, M. H. ; Li, K. S. ; Park, J. S. ; Shin, B. S. ; Ko, J. Y. ; Ahn, Hyo Hyun ; Kim, H. J. ; Park, S. D. ; Jang, S. J. ; Won, Y. H. / Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea : A nationwide retrospective study. In: British Journal of Dermatology. 2012 ; Vol. 166, No. 1. pp. 115-123.
@article{15ba1189e3da4de6bcf00040c76745a0,
title = "Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea: A nationwide retrospective study",
abstract = "Background Giant congenital melanocytic naevi (GCMN) are known risk factors for the development of melanoma. However, melanoma risk among Asians is rarely evaluated. Objectives To evaluate the clinical characteristics and risk of melanoma development from GCMN in Koreans, we performed a nationwide retrospective cohort study in Korea. GCMN were defined as those comprising ≥ 5{\%} body surface area in children or measuring ≥ 20 cm in adults. Methods In total, 131 patients with GCMN were enrolled, with a mean age of 10·3 years (range: birth-70 years). Results The posterior trunk was the most common site (67, 51·1{\%}), followed by lateral trunk, anterior trunk, legs, both anterior and posterior trunk, buttocks, and arms. Satellite naevi were present in 69 cases (52·7{\%}), and axial areas were more commonly involved in patients with satellite naevi than in those without satellite lesions. Atypical features such as rete ridge elongation and bridges were seen, and, among these, pagetoid spread and ballooning cell changes were more common in patients < 4 years old. Proliferative nodules were found in three cases. Melanomas had developed in three of 131 patients (2·3{\%}; a 6-year-old girl, a 14-year-old girl and a 70-year-old man), and the incidence rate was 990 per 100 000 person-years. Melanomas in these three patients consisted of two cutaneous melanomas and one extracutaneous meningeal melanoma. Conclusions We should be aware of melanoma development from GCMN, and lifelong follow-up is required due to the risk of melanoma arising in GCMN.",
author = "Yun, {S. J.} and Kwon, {O. S.} and Han, {J. H.} and Kweon, {S. S.} and Lee, {M. W.} and Lee, {D. Y.} and Kim, {M. B.} and Kim, {Y. C.} and Yoon, {T. Y.} and Chung, {K. Y.} and Il-Hwan Kim and Kim, {K. H.} and Suh, {K. S.} and Lee, {S. J.} and Seo, {Y. J.} and Kim, {K. H.} and Park, {H. J.} and Roh, {M. R.} and Ahn, {K. J.} and Yoon, {T. J.} and Kim, {M. H.} and Li, {K. S.} and Park, {J. S.} and Shin, {B. S.} and Ko, {J. Y.} and Ahn, {Hyo Hyun} and Kim, {H. J.} and Park, {S. D.} and Jang, {S. J.} and Won, {Y. H.}",
year = "2012",
month = "1",
day = "1",
doi = "10.1111/j.1365-2133.2011.10636.x",
language = "English",
volume = "166",
pages = "115--123",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea

T2 - A nationwide retrospective study

AU - Yun, S. J.

AU - Kwon, O. S.

AU - Han, J. H.

AU - Kweon, S. S.

AU - Lee, M. W.

AU - Lee, D. Y.

AU - Kim, M. B.

AU - Kim, Y. C.

AU - Yoon, T. Y.

AU - Chung, K. Y.

AU - Kim, Il-Hwan

AU - Kim, K. H.

AU - Suh, K. S.

AU - Lee, S. J.

AU - Seo, Y. J.

AU - Kim, K. H.

AU - Park, H. J.

AU - Roh, M. R.

AU - Ahn, K. J.

AU - Yoon, T. J.

AU - Kim, M. H.

AU - Li, K. S.

AU - Park, J. S.

AU - Shin, B. S.

AU - Ko, J. Y.

AU - Ahn, Hyo Hyun

AU - Kim, H. J.

AU - Park, S. D.

AU - Jang, S. J.

AU - Won, Y. H.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background Giant congenital melanocytic naevi (GCMN) are known risk factors for the development of melanoma. However, melanoma risk among Asians is rarely evaluated. Objectives To evaluate the clinical characteristics and risk of melanoma development from GCMN in Koreans, we performed a nationwide retrospective cohort study in Korea. GCMN were defined as those comprising ≥ 5% body surface area in children or measuring ≥ 20 cm in adults. Methods In total, 131 patients with GCMN were enrolled, with a mean age of 10·3 years (range: birth-70 years). Results The posterior trunk was the most common site (67, 51·1%), followed by lateral trunk, anterior trunk, legs, both anterior and posterior trunk, buttocks, and arms. Satellite naevi were present in 69 cases (52·7%), and axial areas were more commonly involved in patients with satellite naevi than in those without satellite lesions. Atypical features such as rete ridge elongation and bridges were seen, and, among these, pagetoid spread and ballooning cell changes were more common in patients < 4 years old. Proliferative nodules were found in three cases. Melanomas had developed in three of 131 patients (2·3%; a 6-year-old girl, a 14-year-old girl and a 70-year-old man), and the incidence rate was 990 per 100 000 person-years. Melanomas in these three patients consisted of two cutaneous melanomas and one extracutaneous meningeal melanoma. Conclusions We should be aware of melanoma development from GCMN, and lifelong follow-up is required due to the risk of melanoma arising in GCMN.

AB - Background Giant congenital melanocytic naevi (GCMN) are known risk factors for the development of melanoma. However, melanoma risk among Asians is rarely evaluated. Objectives To evaluate the clinical characteristics and risk of melanoma development from GCMN in Koreans, we performed a nationwide retrospective cohort study in Korea. GCMN were defined as those comprising ≥ 5% body surface area in children or measuring ≥ 20 cm in adults. Methods In total, 131 patients with GCMN were enrolled, with a mean age of 10·3 years (range: birth-70 years). Results The posterior trunk was the most common site (67, 51·1%), followed by lateral trunk, anterior trunk, legs, both anterior and posterior trunk, buttocks, and arms. Satellite naevi were present in 69 cases (52·7%), and axial areas were more commonly involved in patients with satellite naevi than in those without satellite lesions. Atypical features such as rete ridge elongation and bridges were seen, and, among these, pagetoid spread and ballooning cell changes were more common in patients < 4 years old. Proliferative nodules were found in three cases. Melanomas had developed in three of 131 patients (2·3%; a 6-year-old girl, a 14-year-old girl and a 70-year-old man), and the incidence rate was 990 per 100 000 person-years. Melanomas in these three patients consisted of two cutaneous melanomas and one extracutaneous meningeal melanoma. Conclusions We should be aware of melanoma development from GCMN, and lifelong follow-up is required due to the risk of melanoma arising in GCMN.

UR - http://www.scopus.com/inward/record.url?scp=84555202365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84555202365&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2133.2011.10636.x

DO - 10.1111/j.1365-2133.2011.10636.x

M3 - Article

VL - 166

SP - 115

EP - 123

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 1

ER -