Clinical characteristics of Acute Aortic syndrome in Korean patients

From the Korean Multi-Center Registry of Acute Aortic syndrome

Jung Rae Cho, Sanghoon Shin, Jung Sun Kim, Young Guk Ko, Myeong Ki Hong, Yangsoo Jang, Ki Bae Seung, Hun Sik Park, Seung Jea Tahk, Do-Sun Lim, Dong Wun Jeon, In Ho Chae, Duk Kyung Kim, Junghan Yoon, Myung Ho Jeong, Donghoon Choi

Research output: Contribution to journalArticle

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Abstract

Background and Objectives: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-center registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. Subjects and Methods: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10 centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. Results: The mean patient age was 60.1±14.5 years; the male-to-female ratio was M:F=297:231. The prevalent risk factors for AAS included hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%), IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0% underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. Conclusion: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further, prospective study is warranted with a larger number of patients.

Original languageEnglish
Pages (from-to)528-537
Number of pages10
JournalKorean Circulation Journal
Volume42
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1

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Registries
Hematoma
Ulcer
Dissection
Dissecting Aneurysm
Back Pain
Chest Pain
Medical Records
Medicine
Demography
Prospective Studies
Hypertension
Mortality
Therapeutics

Keywords

  • Aortic diseases
  • Dissection
  • Hematoma
  • Population characteristics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Clinical characteristics of Acute Aortic syndrome in Korean patients : From the Korean Multi-Center Registry of Acute Aortic syndrome. / Cho, Jung Rae; Shin, Sanghoon; Kim, Jung Sun; Ko, Young Guk; Hong, Myeong Ki; Jang, Yangsoo; Seung, Ki Bae; Park, Hun Sik; Tahk, Seung Jea; Lim, Do-Sun; Jeon, Dong Wun; Chae, In Ho; Kim, Duk Kyung; Yoon, Junghan; Jeong, Myung Ho; Choi, Donghoon.

In: Korean Circulation Journal, Vol. 42, No. 8, 01.08.2012, p. 528-537.

Research output: Contribution to journalArticle

Cho, JR, Shin, S, Kim, JS, Ko, YG, Hong, MK, Jang, Y, Seung, KB, Park, HS, Tahk, SJ, Lim, D-S, Jeon, DW, Chae, IH, Kim, DK, Yoon, J, Jeong, MH & Choi, D 2012, 'Clinical characteristics of Acute Aortic syndrome in Korean patients: From the Korean Multi-Center Registry of Acute Aortic syndrome', Korean Circulation Journal, vol. 42, no. 8, pp. 528-537. https://doi.org/10.4070/kcj.2012.42.8.528
Cho, Jung Rae ; Shin, Sanghoon ; Kim, Jung Sun ; Ko, Young Guk ; Hong, Myeong Ki ; Jang, Yangsoo ; Seung, Ki Bae ; Park, Hun Sik ; Tahk, Seung Jea ; Lim, Do-Sun ; Jeon, Dong Wun ; Chae, In Ho ; Kim, Duk Kyung ; Yoon, Junghan ; Jeong, Myung Ho ; Choi, Donghoon. / Clinical characteristics of Acute Aortic syndrome in Korean patients : From the Korean Multi-Center Registry of Acute Aortic syndrome. In: Korean Circulation Journal. 2012 ; Vol. 42, No. 8. pp. 528-537.
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AU - Hong, Myeong Ki

AU - Jang, Yangsoo

AU - Seung, Ki Bae

AU - Park, Hun Sik

AU - Tahk, Seung Jea

AU - Lim, Do-Sun

AU - Jeon, Dong Wun

AU - Chae, In Ho

AU - Kim, Duk Kyung

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AU - Choi, Donghoon

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N2 - Background and Objectives: Acute aortic syndrome (AAS) is a heterogeneous group of disorders that often present with severe chest or back pain. It includes acute aortic dissection (AD), intramural hematoma (IMH), dissecting aneurysm, and penetrating aortic ulcer (PAU). The clinical picture of AAS and its prognosis have not been studied in a large number of Korean patients. Therefore, we organized a multi-center registry to identify the clinical characteristics and treatment patterns, as well as long-term outcomes in Korean patients with AAS. Subjects and Methods: Five-hundred twenty-eight patients, who had been diagnosed with AAS, were enrolled into this registry from 10 centers. On a retrospective basis, we collected demographic, laboratory, imaging data, as well as follow-up clinical outcomes by reviewing medical records from individual centers. All the data were collected in core lab and analyzed in detail. Results: The mean patient age was 60.1±14.5 years; the male-to-female ratio was M:F=297:231. The prevalent risk factors for AAS included hypertension (361, 68.4%) and diabetes (52, 11.1%). The components of AAS that are included in this study are acute AD (446, 84.5%), IMH (57, 10.7%), and PAU (11, 2.1%). By type of AAS, patients diagnosed with Stanford A were 45.6% of enrolled patients, whereas those with Stanford B were 54.4% of enrolled patients. Among nearly half of the patients were treated with medicine (55.7%) alone, whereas 40.0% underwent surgery and 4.3% underwent endovascular treatment. Overall, the in-hospital event rate was 21.2% and the in-hospital death rate was 8.1%. The mean follow-up duration was 42.8 months and there showed 22.9% of total event and 10.1% of death during this period. Conclusion: By organizing a multi-center registry of AAS, we could identify the characteristics of AAS in real-world Korean patients. Further, prospective study is warranted with a larger number of patients.

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