Abstract
Objectives: The aim of this study was to determine the risk factors and clinical characteristics of community-acquired acute pyelonephritis (CA-APN) caused by extended-spectrum β-lactamase (ESBL)-producing organisms. Methods: From March 2010 to February 2011, patients with CA-APN were recruited in 11 hospitals in South Korea. Clinical and microbiological data were collected prospectively, and the ESBLs and multilocus sequence types of the ESBL-producing Escherichia coli were characterized. Comparison between CA-APN caused by ESBL-producing Enterobacteriaceae and those by non-ESBL-producing organisms was performed. Results: A total of 566 patients were recruited. Enterobacteriaceae were detected in 526 patients. Forty-six isolates (46/526, 8.7 %) were positive for ESBLs. Clinical and microbiological failure did not differ between the two groups, despite there being fewer patients with ESBL-positive isolates provided with appropriate antibiotics initially (19.6 vs. 93.8 %, p < 0.001). However, the duration of hospitalization was longer in the ESBL group (10.5 vs. 7.0 days, p = 0.012). In a logistic regression model, Charlson score ≥1 point [odds ratio (OR) 3.4, 95 % confidence interval (CI) 1.6-7.0, p = 0.001], antibiotics usage during the previous year (OR 3.1, 95 % CI 1.4-7.2, p = 0.008), and urinary catheterization during the previous month (OR 4.4, 95 % CI 1.1-17.6, p = 0.035) were associated with the risks of CA-APN by ESBL producers. CTX-M-15 (48 %) and CTX-M-14 (38 %) were the most common ESBLs. ST131 was the most common clone (7/24, 29.1 %), which was more frequently resistant to cefepime, fosfomycin, and temocillin. Conclusions: The risk factors for CA-APN by ESBL producers were Charlson score ≥1 point, antibiotics usage during the previous year, and urinary catheterization during the previous month.
| Original language | English |
|---|---|
| Pages (from-to) | 603-612 |
| Number of pages | 10 |
| Journal | Infection |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 Jun 1 |
Fingerprint
Keywords
- Community acquired
- Extended-spectrum β-lactamase
- Risk factor
- Urinary tract infection
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
Clinical characteristics of community-acquired acute pyelonephritis caused by ESBL-producing pathogens in South Korea. / Kim, B.; Kim, J.; Seo, M. R.; Wie, S. H.; Cho, Y. K.; Lim, S. K.; Lee, J. S.; Kwon, K. T.; Lee, H.; Cheong, Hee-Jin; Park, Dae Won; Ryu, S. Y.; Chung, M. H.; Ki, M.; Pai, H.
In: Infection, Vol. 41, No. 3, 01.06.2013, p. 603-612.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical characteristics of community-acquired acute pyelonephritis caused by ESBL-producing pathogens in South Korea
AU - Kim, B.
AU - Kim, J.
AU - Seo, M. R.
AU - Wie, S. H.
AU - Cho, Y. K.
AU - Lim, S. K.
AU - Lee, J. S.
AU - Kwon, K. T.
AU - Lee, H.
AU - Cheong, Hee-Jin
AU - Park, Dae Won
AU - Ryu, S. Y.
AU - Chung, M. H.
AU - Ki, M.
AU - Pai, H.
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Objectives: The aim of this study was to determine the risk factors and clinical characteristics of community-acquired acute pyelonephritis (CA-APN) caused by extended-spectrum β-lactamase (ESBL)-producing organisms. Methods: From March 2010 to February 2011, patients with CA-APN were recruited in 11 hospitals in South Korea. Clinical and microbiological data were collected prospectively, and the ESBLs and multilocus sequence types of the ESBL-producing Escherichia coli were characterized. Comparison between CA-APN caused by ESBL-producing Enterobacteriaceae and those by non-ESBL-producing organisms was performed. Results: A total of 566 patients were recruited. Enterobacteriaceae were detected in 526 patients. Forty-six isolates (46/526, 8.7 %) were positive for ESBLs. Clinical and microbiological failure did not differ between the two groups, despite there being fewer patients with ESBL-positive isolates provided with appropriate antibiotics initially (19.6 vs. 93.8 %, p < 0.001). However, the duration of hospitalization was longer in the ESBL group (10.5 vs. 7.0 days, p = 0.012). In a logistic regression model, Charlson score ≥1 point [odds ratio (OR) 3.4, 95 % confidence interval (CI) 1.6-7.0, p = 0.001], antibiotics usage during the previous year (OR 3.1, 95 % CI 1.4-7.2, p = 0.008), and urinary catheterization during the previous month (OR 4.4, 95 % CI 1.1-17.6, p = 0.035) were associated with the risks of CA-APN by ESBL producers. CTX-M-15 (48 %) and CTX-M-14 (38 %) were the most common ESBLs. ST131 was the most common clone (7/24, 29.1 %), which was more frequently resistant to cefepime, fosfomycin, and temocillin. Conclusions: The risk factors for CA-APN by ESBL producers were Charlson score ≥1 point, antibiotics usage during the previous year, and urinary catheterization during the previous month.
AB - Objectives: The aim of this study was to determine the risk factors and clinical characteristics of community-acquired acute pyelonephritis (CA-APN) caused by extended-spectrum β-lactamase (ESBL)-producing organisms. Methods: From March 2010 to February 2011, patients with CA-APN were recruited in 11 hospitals in South Korea. Clinical and microbiological data were collected prospectively, and the ESBLs and multilocus sequence types of the ESBL-producing Escherichia coli were characterized. Comparison between CA-APN caused by ESBL-producing Enterobacteriaceae and those by non-ESBL-producing organisms was performed. Results: A total of 566 patients were recruited. Enterobacteriaceae were detected in 526 patients. Forty-six isolates (46/526, 8.7 %) were positive for ESBLs. Clinical and microbiological failure did not differ between the two groups, despite there being fewer patients with ESBL-positive isolates provided with appropriate antibiotics initially (19.6 vs. 93.8 %, p < 0.001). However, the duration of hospitalization was longer in the ESBL group (10.5 vs. 7.0 days, p = 0.012). In a logistic regression model, Charlson score ≥1 point [odds ratio (OR) 3.4, 95 % confidence interval (CI) 1.6-7.0, p = 0.001], antibiotics usage during the previous year (OR 3.1, 95 % CI 1.4-7.2, p = 0.008), and urinary catheterization during the previous month (OR 4.4, 95 % CI 1.1-17.6, p = 0.035) were associated with the risks of CA-APN by ESBL producers. CTX-M-15 (48 %) and CTX-M-14 (38 %) were the most common ESBLs. ST131 was the most common clone (7/24, 29.1 %), which was more frequently resistant to cefepime, fosfomycin, and temocillin. Conclusions: The risk factors for CA-APN by ESBL producers were Charlson score ≥1 point, antibiotics usage during the previous year, and urinary catheterization during the previous month.
KW - Community acquired
KW - Extended-spectrum β-lactamase
KW - Risk factor
KW - Urinary tract infection
UR - http://www.scopus.com/inward/record.url?scp=84878866083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878866083&partnerID=8YFLogxK
U2 - 10.1007/s15010-013-0441-z
DO - 10.1007/s15010-013-0441-z
M3 - Article
C2 - 23504297
AN - SCOPUS:84878866083
VL - 41
SP - 603
EP - 612
JO - Infection
JF - Infection
SN - 0300-8126
IS - 3
ER -