Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer's ring

Nationwide Korean study

Seong Jun Lee, Cheol Won Suh, Soon Il Lee, Won Seog Kim, Won Sik Lee, Hyo Jung Kim, Chul Won Choi, Jin Seok Kim, Ho Jin Shin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background/Aims: In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer's ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectively. Methods: From January 2000 through December 2010, we analyzed the medical records of 328 patients from nine Korean institutions who were diagnosed with WR-NHL. Results: The study group comprised 197 male and 131 female patients with a median age of 58 years (range, 14 to 89). The rate of localized disease (stage I/II) was 64.9%, and that of low-risk disease (low/low-intermediate, as defined by the International Prognostic Index) was 76.8%. Diffuse large B-cell lymphoma (DLBCL; 240 patients, 73.2%) was the most common pathologic subtype, followed by peripheral T-cell lymphoma (14 patients, 4.3%) and nasal NK/T-cell lymphoma (14 patients, 4.3%). WR-NHL occurred most frequently in the tonsils (199 patients, 60.6%). Extranodal involvement was greater with the T-cell subtype (20 patients, 42.5%) compared with the B-cell subtype (69 patients, 24.5%). Multivariate analyses showed that age ≥ 62 years, T-cell subtype, and failure to achieve complete remission were significant risk factors for overall survival. Conclusions: DLBCL was found to have a higher incidence in Korea than those incidences reported by other WR-NHL studies. T-cell lymphoma occurred more frequently than did follicular lymphoma. T-cell subtype, age ≥ 62 years, and complete remission failure after first-line treatment were significant poor prognostic factors for overall survival according to the multivariate analysis.

Original languageEnglish
Pages (from-to)352-360
Number of pages9
JournalKorean Journal of Internal Medicine
Volume29
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Non-Hodgkin's Lymphoma
T-Cell Lymphoma
T-Lymphocytes
Incidence
Multivariate Analysis
Peripheral T-Cell Lymphoma
Follicular Lymphoma
Survival
Lymphoma, Large B-Cell, Diffuse
Palatine Tonsil
Korea
Nose
Natural Killer Cells
Medical Records
B-Lymphocytes
Neck
Head

Keywords

  • Diffuse large b-cell lymphoma
  • Head and neck
  • Non-hodgkin lymphoma
  • T-cell lymphoma

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer's ring : Nationwide Korean study. / Lee, Seong Jun; Suh, Cheol Won; Lee, Soon Il; Kim, Won Seog; Lee, Won Sik; Kim, Hyo Jung; Choi, Chul Won; Kim, Jin Seok; Shin, Ho Jin.

In: Korean Journal of Internal Medicine, Vol. 29, No. 3, 01.01.2014, p. 352-360.

Research output: Contribution to journalArticle

Lee, Seong Jun ; Suh, Cheol Won ; Lee, Soon Il ; Kim, Won Seog ; Lee, Won Sik ; Kim, Hyo Jung ; Choi, Chul Won ; Kim, Jin Seok ; Shin, Ho Jin. / Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer's ring : Nationwide Korean study. In: Korean Journal of Internal Medicine. 2014 ; Vol. 29, No. 3. pp. 352-360.
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abstract = "Background/Aims: In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer's ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectively. Methods: From January 2000 through December 2010, we analyzed the medical records of 328 patients from nine Korean institutions who were diagnosed with WR-NHL. Results: The study group comprised 197 male and 131 female patients with a median age of 58 years (range, 14 to 89). The rate of localized disease (stage I/II) was 64.9{\%}, and that of low-risk disease (low/low-intermediate, as defined by the International Prognostic Index) was 76.8{\%}. Diffuse large B-cell lymphoma (DLBCL; 240 patients, 73.2{\%}) was the most common pathologic subtype, followed by peripheral T-cell lymphoma (14 patients, 4.3{\%}) and nasal NK/T-cell lymphoma (14 patients, 4.3{\%}). WR-NHL occurred most frequently in the tonsils (199 patients, 60.6{\%}). Extranodal involvement was greater with the T-cell subtype (20 patients, 42.5{\%}) compared with the B-cell subtype (69 patients, 24.5{\%}). Multivariate analyses showed that age ≥ 62 years, T-cell subtype, and failure to achieve complete remission were significant risk factors for overall survival. Conclusions: DLBCL was found to have a higher incidence in Korea than those incidences reported by other WR-NHL studies. T-cell lymphoma occurred more frequently than did follicular lymphoma. T-cell subtype, age ≥ 62 years, and complete remission failure after first-line treatment were significant poor prognostic factors for overall survival according to the multivariate analysis.",
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T1 - Clinical characteristics, pathological distribution, and prognostic factors in non-Hodgkin lymphoma of Waldeyer's ring

T2 - Nationwide Korean study

AU - Lee, Seong Jun

AU - Suh, Cheol Won

AU - Lee, Soon Il

AU - Kim, Won Seog

AU - Lee, Won Sik

AU - Kim, Hyo Jung

AU - Choi, Chul Won

AU - Kim, Jin Seok

AU - Shin, Ho Jin

PY - 2014/1/1

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N2 - Background/Aims: In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer's ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectively. Methods: From January 2000 through December 2010, we analyzed the medical records of 328 patients from nine Korean institutions who were diagnosed with WR-NHL. Results: The study group comprised 197 male and 131 female patients with a median age of 58 years (range, 14 to 89). The rate of localized disease (stage I/II) was 64.9%, and that of low-risk disease (low/low-intermediate, as defined by the International Prognostic Index) was 76.8%. Diffuse large B-cell lymphoma (DLBCL; 240 patients, 73.2%) was the most common pathologic subtype, followed by peripheral T-cell lymphoma (14 patients, 4.3%) and nasal NK/T-cell lymphoma (14 patients, 4.3%). WR-NHL occurred most frequently in the tonsils (199 patients, 60.6%). Extranodal involvement was greater with the T-cell subtype (20 patients, 42.5%) compared with the B-cell subtype (69 patients, 24.5%). Multivariate analyses showed that age ≥ 62 years, T-cell subtype, and failure to achieve complete remission were significant risk factors for overall survival. Conclusions: DLBCL was found to have a higher incidence in Korea than those incidences reported by other WR-NHL studies. T-cell lymphoma occurred more frequently than did follicular lymphoma. T-cell subtype, age ≥ 62 years, and complete remission failure after first-line treatment were significant poor prognostic factors for overall survival according to the multivariate analysis.

AB - Background/Aims: In Asia, the incidence of non-Hodgkin lymphoma (NHL) has increased in recent decades. Waldeyer's ring (WR) is the most common site of NHL involving the head and neck. In this study, the pathological distribution of WR-NHL and its clinical features were analyzed retrospectively. Methods: From January 2000 through December 2010, we analyzed the medical records of 328 patients from nine Korean institutions who were diagnosed with WR-NHL. Results: The study group comprised 197 male and 131 female patients with a median age of 58 years (range, 14 to 89). The rate of localized disease (stage I/II) was 64.9%, and that of low-risk disease (low/low-intermediate, as defined by the International Prognostic Index) was 76.8%. Diffuse large B-cell lymphoma (DLBCL; 240 patients, 73.2%) was the most common pathologic subtype, followed by peripheral T-cell lymphoma (14 patients, 4.3%) and nasal NK/T-cell lymphoma (14 patients, 4.3%). WR-NHL occurred most frequently in the tonsils (199 patients, 60.6%). Extranodal involvement was greater with the T-cell subtype (20 patients, 42.5%) compared with the B-cell subtype (69 patients, 24.5%). Multivariate analyses showed that age ≥ 62 years, T-cell subtype, and failure to achieve complete remission were significant risk factors for overall survival. Conclusions: DLBCL was found to have a higher incidence in Korea than those incidences reported by other WR-NHL studies. T-cell lymphoma occurred more frequently than did follicular lymphoma. T-cell subtype, age ≥ 62 years, and complete remission failure after first-line treatment were significant poor prognostic factors for overall survival according to the multivariate analysis.

KW - Diffuse large b-cell lymphoma

KW - Head and neck

KW - Non-hodgkin lymphoma

KW - T-cell lymphoma

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