Clinical courses and outcomes of hospitalized adult patients with seasonal influenza in Korea, 2011-2012

Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance

Kyung Wook Hong, Hee-Jin Cheong, Wonseok Choi, Jacob Lee, Seong Heon Wie, Ji Hyeon Baek, Hyo Youl Kim, Hye Won Jeong, Woo Joo Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Influenza is an acute respiratory illness, which can be accompanied by complications such as pneumonia. This study was conducted to survey the clinical courses and outcomes of hospitalized adult patients with laboratory-confirmed seasonal influenza. A prospective caseecontrol study was performed in adult influenza patients who were admitted to hospitals participating in the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system in Korea from October 2011 to May 2012. Cases with complicated influenza were compared to those without complications. A total of 123 (5.6%) patientsamong 2184 laboratory-confirmed adult influenza patients were hospitalized during the 2011-2012 influenza epidemic season. Forty (32.5%) experienced 50 complication episodes. Age older than 60 years (P < 0.01), male sex (P = 0.04), diabetes (P < 0.01), chronic cardiovascular disease (P < 0.01) and neuromuscular disease (P =0.02) were significantly related to development of complications in univariate analysis. Multivariate logistic regression analysis revealed that diabetes (odds ratio [OR] 3.63, 95% confidence interval [CI] 1.15-11.51, P = 0.02) was an independent risk factor for complicated seasonal influenza. C-reactive protein (CRP) was discriminative between complicated and uncomplicated influenza (cutoff value 13 mg/L, sensitivity 70%, specificity 74%). Complicated patients received antibiotics more frequently (P < 0.01) with longer hospital stays (P = 0.01). In conclusion, diabetic patients are at great risk for complicated influenza, and CRP would be useful to predicting complication. Therefore, early interventions such as antiviral therapy should be considered for high risk patients with diabetes, especially those with increased serum CRP level

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalJournal of Infection and Chemotherapy
Volume20
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Korea
Human Influenza
Morbidity
Mortality
C-Reactive Protein
Neuromuscular Diseases
Antiviral Agents
Blood Proteins
Length of Stay
Pneumonia
Chronic Disease
Cardiovascular Diseases
Logistic Models
Odds Ratio
Regression Analysis
Prospective Studies
Confidence Intervals
Anti-Bacterial Agents
Sensitivity and Specificity

Keywords

  • ComplicationS.
  • Hospitalized
  • Influenza
  • Risk factors

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Clinical courses and outcomes of hospitalized adult patients with seasonal influenza in Korea, 2011-2012 : Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance. / Hong, Kyung Wook; Cheong, Hee-Jin; Choi, Wonseok; Lee, Jacob; Wie, Seong Heon; Baek, Ji Hyeon; Kim, Hyo Youl; Jeong, Hye Won; Kim, Woo Joo.

In: Journal of Infection and Chemotherapy, Vol. 20, No. 1, 01.01.2014, p. 9-14.

Research output: Contribution to journalArticle

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abstract = "Influenza is an acute respiratory illness, which can be accompanied by complications such as pneumonia. This study was conducted to survey the clinical courses and outcomes of hospitalized adult patients with laboratory-confirmed seasonal influenza. A prospective caseecontrol study was performed in adult influenza patients who were admitted to hospitals participating in the Hospital-based Influenza Morbidity and Mortality (HIMM) surveillance system in Korea from October 2011 to May 2012. Cases with complicated influenza were compared to those without complications. A total of 123 (5.6{\%}) patientsamong 2184 laboratory-confirmed adult influenza patients were hospitalized during the 2011-2012 influenza epidemic season. Forty (32.5{\%}) experienced 50 complication episodes. Age older than 60 years (P < 0.01), male sex (P = 0.04), diabetes (P < 0.01), chronic cardiovascular disease (P < 0.01) and neuromuscular disease (P =0.02) were significantly related to development of complications in univariate analysis. Multivariate logistic regression analysis revealed that diabetes (odds ratio [OR] 3.63, 95{\%} confidence interval [CI] 1.15-11.51, P = 0.02) was an independent risk factor for complicated seasonal influenza. C-reactive protein (CRP) was discriminative between complicated and uncomplicated influenza (cutoff value 13 mg/L, sensitivity 70{\%}, specificity 74{\%}). Complicated patients received antibiotics more frequently (P < 0.01) with longer hospital stays (P = 0.01). In conclusion, diabetic patients are at great risk for complicated influenza, and CRP would be useful to predicting complication. Therefore, early interventions such as antiviral therapy should be considered for high risk patients with diabetes, especially those with increased serum CRP level",
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