Clinical efficacy of primary tumor volume measurements

Comparison of different primary sites

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9 Citations (Scopus)

Abstract

Objectives. The purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity. Methods. A retrospective analysis of 85 patients with oral cavity or oropharynx cancer. The tumor area was manually outlined from axial magnetic resonance (MR) series. The software calculated the tumor volumes, automatically. The values of the primary tumor volumes were then subdivided into separate groups (≤ 3,500 mm3, > 3,500 mm 3). Results. The prognostic indicators were the cT and cN (oral cavity); age, primary site, cT, cN, and primary tumor volume (oropharynx) on the univariate analysis. There was no significant prognostic factor for oral cavity cancer on the multivariate analysis. Primary site, cN, and primary tumor volume were independent prognostic indicators for oropharynx cancer by multivariate analysis. Conclusion. Primary tumor volume measurement is a reliable way to stratify outcome, and make up for the weak points in the American Joint Committee on Cancer staging system with oropharynx cancer.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalClinical and Experimental Otorhinolaryngology
Volume2
Issue number2
DOIs
Publication statusPublished - 2009 Jan 1

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Tumor Burden
Oropharyngeal Neoplasms
Mouth
Oropharynx
Mouth Neoplasms
Multivariate Analysis
Neoplasm Staging
Magnetic Resonance Spectroscopy
Software
Neoplasms

Keywords

  • Lymphatic metastasis
  • Mouth neoplasm
  • Oropharyngeal neoplasm
  • Prognosis
  • Tumor volume

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

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title = "Clinical efficacy of primary tumor volume measurements: Comparison of different primary sites",
abstract = "Objectives. The purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity. Methods. A retrospective analysis of 85 patients with oral cavity or oropharynx cancer. The tumor area was manually outlined from axial magnetic resonance (MR) series. The software calculated the tumor volumes, automatically. The values of the primary tumor volumes were then subdivided into separate groups (≤ 3,500 mm3, > 3,500 mm 3). Results. The prognostic indicators were the cT and cN (oral cavity); age, primary site, cT, cN, and primary tumor volume (oropharynx) on the univariate analysis. There was no significant prognostic factor for oral cavity cancer on the multivariate analysis. Primary site, cN, and primary tumor volume were independent prognostic indicators for oropharynx cancer by multivariate analysis. Conclusion. Primary tumor volume measurement is a reliable way to stratify outcome, and make up for the weak points in the American Joint Committee on Cancer staging system with oropharynx cancer.",
keywords = "Lymphatic metastasis, Mouth neoplasm, Oropharyngeal neoplasm, Prognosis, Tumor volume",
author = "Chung, {Eun Jae} and Nam-Joon Lee and Seung-Kuk Baek and Kwon, {Soon Young} and Jeong-Soo Woo and Kwang-Yoon Jung",
year = "2009",
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doi = "10.3342/ceo.2009.2.2.78",
language = "English",
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T1 - Clinical efficacy of primary tumor volume measurements

T2 - Comparison of different primary sites

AU - Chung, Eun Jae

AU - Lee, Nam-Joon

AU - Baek, Seung-Kuk

AU - Kwon, Soon Young

AU - Woo, Jeong-Soo

AU - Jung, Kwang-Yoon

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Objectives. The purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity. Methods. A retrospective analysis of 85 patients with oral cavity or oropharynx cancer. The tumor area was manually outlined from axial magnetic resonance (MR) series. The software calculated the tumor volumes, automatically. The values of the primary tumor volumes were then subdivided into separate groups (≤ 3,500 mm3, > 3,500 mm 3). Results. The prognostic indicators were the cT and cN (oral cavity); age, primary site, cT, cN, and primary tumor volume (oropharynx) on the univariate analysis. There was no significant prognostic factor for oral cavity cancer on the multivariate analysis. Primary site, cN, and primary tumor volume were independent prognostic indicators for oropharynx cancer by multivariate analysis. Conclusion. Primary tumor volume measurement is a reliable way to stratify outcome, and make up for the weak points in the American Joint Committee on Cancer staging system with oropharynx cancer.

AB - Objectives. The purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity. Methods. A retrospective analysis of 85 patients with oral cavity or oropharynx cancer. The tumor area was manually outlined from axial magnetic resonance (MR) series. The software calculated the tumor volumes, automatically. The values of the primary tumor volumes were then subdivided into separate groups (≤ 3,500 mm3, > 3,500 mm 3). Results. The prognostic indicators were the cT and cN (oral cavity); age, primary site, cT, cN, and primary tumor volume (oropharynx) on the univariate analysis. There was no significant prognostic factor for oral cavity cancer on the multivariate analysis. Primary site, cN, and primary tumor volume were independent prognostic indicators for oropharynx cancer by multivariate analysis. Conclusion. Primary tumor volume measurement is a reliable way to stratify outcome, and make up for the weak points in the American Joint Committee on Cancer staging system with oropharynx cancer.

KW - Lymphatic metastasis

KW - Mouth neoplasm

KW - Oropharyngeal neoplasm

KW - Prognosis

KW - Tumor volume

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