Clinical features and outcomes of gastric variceal bleeding

retrospective Korean multicenter data.

Moon Young Kim, Soon-Ho Um, Soon Koo Baik, Yeon Seok Seo, Soo Young Park, Jung Il Lee, Jin Woo Lee, Gab Jin Cheon, Joo Hyun Sohn, Tae Yeob Kim, Young Suk Lim, Tae Hyo Kim, Tae Hee Lee, Sung Jae Park, Seung Ha Park, Jin Dong Kim, Sang Young Han, Chang Soo Choi, Eun Young Cho, Dong Joon Kim & 16 others Jae Seok Hwang, Byoung Kuk Jang, June Sung Lee, Sang Gyune Kim, Young Seok Kim, So Young Kwon, Won Hyeok Choe, Chang Hyeong Lee, Byung Seok Kim, Jae Young Jang, Soung Won Jeong, Byung Ho Kim, Jae Jun Shim, Yong Kyun Cho, Moon Soo Koh, Hyun Woong Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis.

Original languageEnglish
Pages (from-to)36-44
Number of pages9
JournalClinical and molecular hepatology
Volume19
Issue number1
DOIs
Publication statusPublished - 2013 Mar 1
Externally publishedYes

Fingerprint

Stomach
Hemorrhage
Hemostasis
Odds Ratio
Mortality
Transjugular Intrahepatic Portasystemic Shunt
Balloon Occlusion
Republic of Korea
Sclerotherapy
Korea
Liver Cirrhosis
Multicenter Studies
Ligation
Therapeutics
Referral and Consultation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical features and outcomes of gastric variceal bleeding : retrospective Korean multicenter data. / Kim, Moon Young; Um, Soon-Ho; Baik, Soon Koo; Seo, Yeon Seok; Park, Soo Young; Lee, Jung Il; Lee, Jin Woo; Cheon, Gab Jin; Sohn, Joo Hyun; Kim, Tae Yeob; Lim, Young Suk; Kim, Tae Hyo; Lee, Tae Hee; Park, Sung Jae; Park, Seung Ha; Kim, Jin Dong; Han, Sang Young; Choi, Chang Soo; Cho, Eun Young; Kim, Dong Joon; Hwang, Jae Seok; Jang, Byoung Kuk; Lee, June Sung; Kim, Sang Gyune; Kim, Young Seok; Kwon, So Young; Choe, Won Hyeok; Lee, Chang Hyeong; Kim, Byung Seok; Jang, Jae Young; Jeong, Soung Won; Kim, Byung Ho; Shim, Jae Jun; Cho, Yong Kyun; Koh, Moon Soo; Lee, Hyun Woong.

In: Clinical and molecular hepatology, Vol. 19, No. 1, 01.03.2013, p. 36-44.

Research output: Contribution to journalArticle

Kim, MY, Um, S-H, Baik, SK, Seo, YS, Park, SY, Lee, JI, Lee, JW, Cheon, GJ, Sohn, JH, Kim, TY, Lim, YS, Kim, TH, Lee, TH, Park, SJ, Park, SH, Kim, JD, Han, SY, Choi, CS, Cho, EY, Kim, DJ, Hwang, JS, Jang, BK, Lee, JS, Kim, SG, Kim, YS, Kwon, SY, Choe, WH, Lee, CH, Kim, BS, Jang, JY, Jeong, SW, Kim, BH, Shim, JJ, Cho, YK, Koh, MS & Lee, HW 2013, 'Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data.', Clinical and molecular hepatology, vol. 19, no. 1, pp. 36-44. https://doi.org/10.3350/cmh.2013.19.1.36
Kim, Moon Young ; Um, Soon-Ho ; Baik, Soon Koo ; Seo, Yeon Seok ; Park, Soo Young ; Lee, Jung Il ; Lee, Jin Woo ; Cheon, Gab Jin ; Sohn, Joo Hyun ; Kim, Tae Yeob ; Lim, Young Suk ; Kim, Tae Hyo ; Lee, Tae Hee ; Park, Sung Jae ; Park, Seung Ha ; Kim, Jin Dong ; Han, Sang Young ; Choi, Chang Soo ; Cho, Eun Young ; Kim, Dong Joon ; Hwang, Jae Seok ; Jang, Byoung Kuk ; Lee, June Sung ; Kim, Sang Gyune ; Kim, Young Seok ; Kwon, So Young ; Choe, Won Hyeok ; Lee, Chang Hyeong ; Kim, Byung Seok ; Jang, Jae Young ; Jeong, Soung Won ; Kim, Byung Ho ; Shim, Jae Jun ; Cho, Yong Kyun ; Koh, Moon Soo ; Lee, Hyun Woong. / Clinical features and outcomes of gastric variceal bleeding : retrospective Korean multicenter data. In: Clinical and molecular hepatology. 2013 ; Vol. 19, No. 1. pp. 36-44.
@article{c0edd2693de84a4a99471b5f11a536b5,
title = "Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data.",
abstract = "While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30{\%}), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. The initial hemostasis failed in 6.1{\%} of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5{\%} of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3{\%}; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis.",
author = "Kim, {Moon Young} and Soon-Ho Um and Baik, {Soon Koo} and Seo, {Yeon Seok} and Park, {Soo Young} and Lee, {Jung Il} and Lee, {Jin Woo} and Cheon, {Gab Jin} and Sohn, {Joo Hyun} and Kim, {Tae Yeob} and Lim, {Young Suk} and Kim, {Tae Hyo} and Lee, {Tae Hee} and Park, {Sung Jae} and Park, {Seung Ha} and Kim, {Jin Dong} and Han, {Sang Young} and Choi, {Chang Soo} and Cho, {Eun Young} and Kim, {Dong Joon} and Hwang, {Jae Seok} and Jang, {Byoung Kuk} and Lee, {June Sung} and Kim, {Sang Gyune} and Kim, {Young Seok} and Kwon, {So Young} and Choe, {Won Hyeok} and Lee, {Chang Hyeong} and Kim, {Byung Seok} and Jang, {Jae Young} and Jeong, {Soung Won} and Kim, {Byung Ho} and Shim, {Jae Jun} and Cho, {Yong Kyun} and Koh, {Moon Soo} and Lee, {Hyun Woong}",
year = "2013",
month = "3",
day = "1",
doi = "10.3350/cmh.2013.19.1.36",
language = "English",
volume = "19",
pages = "36--44",
journal = "Clinical and molecular hepatology",
issn = "2287-2728",
publisher = "Korean Association for the Study of the Liver",
number = "1",

}

TY - JOUR

T1 - Clinical features and outcomes of gastric variceal bleeding

T2 - retrospective Korean multicenter data.

AU - Kim, Moon Young

AU - Um, Soon-Ho

AU - Baik, Soon Koo

AU - Seo, Yeon Seok

AU - Park, Soo Young

AU - Lee, Jung Il

AU - Lee, Jin Woo

AU - Cheon, Gab Jin

AU - Sohn, Joo Hyun

AU - Kim, Tae Yeob

AU - Lim, Young Suk

AU - Kim, Tae Hyo

AU - Lee, Tae Hee

AU - Park, Sung Jae

AU - Park, Seung Ha

AU - Kim, Jin Dong

AU - Han, Sang Young

AU - Choi, Chang Soo

AU - Cho, Eun Young

AU - Kim, Dong Joon

AU - Hwang, Jae Seok

AU - Jang, Byoung Kuk

AU - Lee, June Sung

AU - Kim, Sang Gyune

AU - Kim, Young Seok

AU - Kwon, So Young

AU - Choe, Won Hyeok

AU - Lee, Chang Hyeong

AU - Kim, Byung Seok

AU - Jang, Jae Young

AU - Jeong, Soung Won

AU - Kim, Byung Ho

AU - Shim, Jae Jun

AU - Cho, Yong Kyun

AU - Koh, Moon Soo

AU - Lee, Hyun Woong

PY - 2013/3/1

Y1 - 2013/3/1

N2 - While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis.

AB - While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0±11.0 years, mean±SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis.

UR - http://www.scopus.com/inward/record.url?scp=84886878797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886878797&partnerID=8YFLogxK

U2 - 10.3350/cmh.2013.19.1.36

DO - 10.3350/cmh.2013.19.1.36

M3 - Article

VL - 19

SP - 36

EP - 44

JO - Clinical and molecular hepatology

JF - Clinical and molecular hepatology

SN - 2287-2728

IS - 1

ER -