Clinical features and treatment outcomes of adult B- and T-lymphoblastic lymphoma: Results of multicentre analysis in Korea

Myung Hee Chang, Seok Jin Kim, Kihyun Kim, Sung Yong Oh, Dae Ho Lee, Jooryung Huh, Young Hyeh Ko, Chul Won Choi, Deok Hwan Yang, Jong Ho Won, Won Seog Kim, Cheolwon Suh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We performed a retrospective multicentre analysis to study the clinical features and treatment outcomes of B-lymphoblastic lymphoma (B-LBL) and T-lymphoblastic lymphoma (T-LBL) in Asian adult patients, and identify risk factors that predict relapse and poor prognosis. Fifty-five newly diagnosed patients (45 T-LBL and 10 B-LBL) were analysed. All patients were treated with intensive chemotherapy regimens including VPDL (vincristine, prednisolone, daunorubicin, L-asparaginase), CALGB (Cancer and leukemia group B), and Stanford/Northern California Oncology Group (NCOG). There was no difference of clinical features between B- and T-LBL except the frequent site of involvement. The overall response rate including complete response (28/55, 50.9%) and partial response (18/55, 32.7%) was 83.6%. Among 46 responders, 22 patients relapsed leading to 20 deaths. Partial responders showed more frequent relapse (10/18, 55.6%) than complete responders (11/28, 39.2%). The median progression-free survival (PFS) was 17 months (95% confidence interval, 11.5-22.5), and the 2-year overall survival was 52 ± 7% with a median follow-up of 50 months (range 8-152). Treatment outcome of T-LBL and B-LBL was not significantly different in terms of response and survival. The presence of pleural effusion was significantly prognostic for overall and PFS (p < 0.05). In conclusion, clinical features and treatment outcome of Asian adult LBL were comparable to previous results, and the prognosis is still poor despite intensive chemotherapy.

Original languageEnglish
Pages (from-to)1119-1125
Number of pages7
JournalLeukemia and Lymphoma
Volume50
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • B-cell
  • Lymphoblastic lymphoma
  • Prognosis
  • T-cell

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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