Clinical features and treatment outcomes of patients with tearing after chemotherapy

Jinhwan Park, Joohyun Kim, Se Hyun Baek

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the clinical features and treatment outcomes of patients complaining of tearing after receiving chemotherapy. Methods: The clinical records of patients who complained of tearing between August 2014 and February 2016, and underwent or were undergoing chemotherapy were retrospectively reviewed. Clinical measurements were as follows: LipiView® interferometer (lipid layer thickness and meibography), lacrimal drainage examinations (syringing), and outcomes at 6 months after treatment. Results: This study included 34 eyes of 17 patients with a mean age of 62.4 ± 14.82 years. The mean follow-up period was 9.6 months. On syringing, 10 eyes (29.4%) showed total regurgitation, 19 eyes (55.9%) showed partial regurgitation, and 5 eyes (14.7%) showed no regurgitation. On LipiView®, mean lipid layer thickness was 34.5 nm (range, 20–89 nm). Mean meiboscore was 2.15 ± 0.86 in upper eyelid and 2.53 ± 0.79 in lower eyelid. Patients were treated with silicon tube intubation (STI) (10 eyes, 29.4%), dacryocystorhinostomy (DCR) (4 eyes, 17.6%), conjunctivodacryocystorhinostomy (CDCR) (8 eyes, 11.8%), DCR combined with CDCR (1 eyes, 8.8%), and conservative care (11 eyes, 32.4%). Mean time interval from onset of tearing to first clinic visit was 1.4 months in the conservative care group, 2.9 months in the STI and DCR groups, and 6.0 months in the CDCR group. Conclusion: Because of the high incidence of accompanying meibomian gland loss in cases of lacrimal drainage system (LDS) obstruction, reflex tearing by mebibomian gland dysfunction should also be considered for proper management of tearing. Early recognition and management of LDS stenosis could result in patients undergoing surgery with a lower burden.

Original languageEnglish
JournalEye (Basingstoke)
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Drug Therapy
Dacryocystorhinostomy
Tears
Drainage
Silicon
Eyelids
Intubation
Meibomian Glands
Lipids
Ambulatory Care
Reflex
Pathologic Constriction
Incidence

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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Clinical features and treatment outcomes of patients with tearing after chemotherapy. / Park, Jinhwan; Kim, Joohyun; Baek, Se Hyun.

In: Eye (Basingstoke), 01.01.2018.

Research output: Contribution to journalArticle

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title = "Clinical features and treatment outcomes of patients with tearing after chemotherapy",
abstract = "Purpose: To evaluate the clinical features and treatment outcomes of patients complaining of tearing after receiving chemotherapy. Methods: The clinical records of patients who complained of tearing between August 2014 and February 2016, and underwent or were undergoing chemotherapy were retrospectively reviewed. Clinical measurements were as follows: LipiView{\circledR} interferometer (lipid layer thickness and meibography), lacrimal drainage examinations (syringing), and outcomes at 6 months after treatment. Results: This study included 34 eyes of 17 patients with a mean age of 62.4 ± 14.82 years. The mean follow-up period was 9.6 months. On syringing, 10 eyes (29.4{\%}) showed total regurgitation, 19 eyes (55.9{\%}) showed partial regurgitation, and 5 eyes (14.7{\%}) showed no regurgitation. On LipiView{\circledR}, mean lipid layer thickness was 34.5 nm (range, 20–89 nm). Mean meiboscore was 2.15 ± 0.86 in upper eyelid and 2.53 ± 0.79 in lower eyelid. Patients were treated with silicon tube intubation (STI) (10 eyes, 29.4{\%}), dacryocystorhinostomy (DCR) (4 eyes, 17.6{\%}), conjunctivodacryocystorhinostomy (CDCR) (8 eyes, 11.8{\%}), DCR combined with CDCR (1 eyes, 8.8{\%}), and conservative care (11 eyes, 32.4{\%}). Mean time interval from onset of tearing to first clinic visit was 1.4 months in the conservative care group, 2.9 months in the STI and DCR groups, and 6.0 months in the CDCR group. Conclusion: Because of the high incidence of accompanying meibomian gland loss in cases of lacrimal drainage system (LDS) obstruction, reflex tearing by mebibomian gland dysfunction should also be considered for proper management of tearing. Early recognition and management of LDS stenosis could result in patients undergoing surgery with a lower burden.",
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