Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients

Sun Min Lim, Minkyu Jung, Sang Joon Shin, Se-Jin Baek, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Nam Kyu Kim, Joong Bae Ahn

Research output: Contribution to journalArticle

1 Citation (Scopus)


Background: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue. Objective: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis. Methods: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013. Results: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6%) patients had stage ≥3, and distant metastasis was found in 10 (34.4%) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006). Conclusion: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalOncology (Switzerland)
Issue number4
Publication statusPublished - 2014 Apr 6
Externally publishedYes



  • Colorectal cancer
  • Organ transplantation
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lim, S. M., Jung, M., Shin, S. J., Baek, S-J., Hur, H., Min, B. S., Baik, S. H., Kim, N. K., & Ahn, J. B. (2014). Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients. Oncology (Switzerland), 88(4), 195-200.