Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients

Sun Min Lim, Minkyu Jung, Sang Joon Shin, Se-Jin Baek, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Nam Kyu Kim, Joong Bae Ahn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue. Objective: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis. Methods: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013. Results: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6%) patients had stage ≥3, and distant metastasis was found in 10 (34.4%) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006). Conclusion: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalOncology (Switzerland)
Volume88
Issue number4
DOIs
Publication statusPublished - 2014 Apr 6
Externally publishedYes

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Adenocarcinoma
Colorectal Neoplasms
Transplantation
Neoplasm Metastasis
Neoplasms
Survival
Incidence
Disease-Free Survival
Allografts
Transplant Recipients
Multivariate Analysis
Databases
Guidelines
Transplants
Therapeutics

Keywords

  • Colorectal cancer
  • Organ transplantation
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients. / Lim, Sun Min; Jung, Minkyu; Shin, Sang Joon; Baek, Se-Jin; Hur, Hyuk; Min, Byung Soh; Baik, Seung Hyuk; Kim, Nam Kyu; Ahn, Joong Bae.

In: Oncology (Switzerland), Vol. 88, No. 4, 06.04.2014, p. 195-200.

Research output: Contribution to journalArticle

Lim, SM, Jung, M, Shin, SJ, Baek, S-J, Hur, H, Min, BS, Baik, SH, Kim, NK & Ahn, JB 2014, 'Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients', Oncology (Switzerland), vol. 88, no. 4, pp. 195-200. https://doi.org/10.1159/000369254
Lim, Sun Min ; Jung, Minkyu ; Shin, Sang Joon ; Baek, Se-Jin ; Hur, Hyuk ; Min, Byung Soh ; Baik, Seung Hyuk ; Kim, Nam Kyu ; Ahn, Joong Bae. / Clinical implications from a single-center study of colorectal adenocarcinoma in transplant recipients. In: Oncology (Switzerland). 2014 ; Vol. 88, No. 4. pp. 195-200.
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