Clinical implications of pneumococcal serotypes: Invasive disease potential, clinical presentations, and antibiotic resistance

Joon-Young Song, Moon H. Nahm, M. Allen Moseley

Research output: Contribution to journalReview article

75 Citations (Scopus)

Abstract

Streptococcus pneumoniae can asymptomatically colonize the nasopharynx and cause adiverse range of illnesses. This clinical spectrum from colonization to invasive pneumococcal disease (IPD) appears to depend on the pneumococcal capsular serotype rather than the genetic background. According to a literature review, serotypes 1, 4, 5, 7F, 8, 12F, 14, 18C, and 19A are more likely to cause IPD. Although serotypes 1 and 19A are the predominant causes of invasive pneumococcal pneumonia, serotype 14 remains one of the most common etiologic agents of non-bacteremic pneumonia in adults, even after 7-valent pneumococcal conjugate vaccine (PCV7) introduction. Serotypes 1, 3, and 19A pneumococci are likely to cause empyema and hemolytic uremic syndrome. Serotype 1 pneumococcal meningitis is prevalent in the African meningitis belt, with a high fatality rate. In contrast to the capsule type, genotype is more closely associated with antibiotic resistance. CC320/271 strains expressing serotype 19A are multidrug-resistant (MDR) and prevalent worldwide in the era of PCV7. Several clones of MDR serotype 6C pneumococci emerged, and a MDR 6D clone (ST282) has been identified in Korea. Since the pneumococcal epidemiology of capsule types varies geographically and temporally, a nationwide serosurveillance system is vital to establishing appropriate vaccination strategies for each country.

Original languageEnglish
Pages (from-to)4-15
Number of pages12
JournalJournal of Korean Medical Science
Volume28
Issue number1
DOIs
Publication statusPublished - 2013 Mar 13

Fingerprint

Microbial Drug Resistance
Streptococcus pneumoniae
Capsules
Clone Cells
Pneumococcal Meningitis
Pneumococcal Pneumonia
Conjugate Vaccines
Pneumococcal Vaccines
Hemolytic-Uremic Syndrome
Empyema
Nasopharynx
Serogroup
Korea
Meningitis
Pneumonia
Vaccination
Epidemiology
Genotype

Keywords

  • Bacterial capsules
  • Pneumococcal infections
  • Polysaccharides, bacterial
  • Serotyping
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical implications of pneumococcal serotypes : Invasive disease potential, clinical presentations, and antibiotic resistance. / Song, Joon-Young; Nahm, Moon H.; Moseley, M. Allen.

In: Journal of Korean Medical Science, Vol. 28, No. 1, 13.03.2013, p. 4-15.

Research output: Contribution to journalReview article

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