Abstract
Background: Asthma is the most common respiratory crisis encountered in clinical practice, occurring in up to 4% of all pregnancies. Pregnancy often appears to alter the course of asthma. But the mechanisms responsible for variable changes in the asthma course during pregnancy remain unknown. Poor control and exacerbations of asthma during pregnancy may result in serious maternal and fetal complications. To investigate the course of asthma during pregnancy in korean women, we did a retrograde study of 27 pregnant women who had been admitted to Korea University Hospital for asthma worsened. Method: Twenty seven pregnant women who had been visited to Korea University Hospital for asthma worsened were enrolled in our retrospective study. We reviewed medical recordings and interviewed patients with asthma. Results: Twenty seven pregnant women with asthma were evaluated, and 25 patients were enrolled to our study. Two patients experienced abortions at 6 weeks and 25 weeks gestation, respectively. The period of asthma worsened was commonly during weeks 20 to 28 of gestation. And all patients worsened were improved during the last 4 weeks of pregnancy. Twenty (80%) of 25 women whose asthma worsened during pregnancy reverted toward their prepregnancy status after delivery (p<0.002). The causes of asthma worsened during pregnancy are reduction or even complete cessation of medication due to fears about its safety (40%), worsening after upper respiratory infection (28%), and unknown (32%). There were no adverse perinatal outcomes in 25 pregnant asthma subjects. Conclusions: A major problem of therapy for asthma during pregnancy is reduction or even complete cessation of medication due to fears of fetal effects. Therefore, maternal education and optimal clinical and pharmacologic management is necessary to mitigate maternal and fetal complications.
| Original language | English |
|---|---|
| Pages (from-to) | 548-554 |
| Number of pages | 7 |
| Journal | Tuberculosis and Respiratory Diseases |
| Volume | 46 |
| Issue number | 4 |
| Publication status | Published - 1999 Jan 1 |
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Keywords
- Asthma
- Pregnancy
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Infectious Diseases
Cite this
Clinical investigation of women with asthma worsened during pregnancy. / Young Hwan Kwon, Hwan Kwon; Kyung Kyu Kim, Kyu Kim; Hye Cheol Jung, Cheol Jung; Lee, Sung Yong; Kim, Je Hyeong; So Ra Lee, Ra Lee; Sang Yeub Lee, Yeub Lee; Sin Hyeong Lee, Hyeong Lee; Jae Yun Cho, Yun Cho; Jae Jeong Shim, Jeong Shim; Kyung Ho Kang, Ho Kang; Se Hwa Yoo, Hwa Yoo; Kwang Ho In, Ho In.
In: Tuberculosis and Respiratory Diseases, Vol. 46, No. 4, 01.01.1999, p. 548-554.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical investigation of women with asthma worsened during pregnancy
AU - Young Hwan Kwon, Hwan Kwon
AU - Kyung Kyu Kim, Kyu Kim
AU - Hye Cheol Jung, Cheol Jung
AU - Lee, Sung Yong
AU - Kim, Je Hyeong
AU - So Ra Lee, Ra Lee
AU - Sang Yeub Lee, Yeub Lee
AU - Sin Hyeong Lee, Hyeong Lee
AU - Jae Yun Cho, Yun Cho
AU - Jae Jeong Shim, Jeong Shim
AU - Kyung Ho Kang, Ho Kang
AU - Se Hwa Yoo, Hwa Yoo
AU - Kwang Ho In, Ho In
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Background: Asthma is the most common respiratory crisis encountered in clinical practice, occurring in up to 4% of all pregnancies. Pregnancy often appears to alter the course of asthma. But the mechanisms responsible for variable changes in the asthma course during pregnancy remain unknown. Poor control and exacerbations of asthma during pregnancy may result in serious maternal and fetal complications. To investigate the course of asthma during pregnancy in korean women, we did a retrograde study of 27 pregnant women who had been admitted to Korea University Hospital for asthma worsened. Method: Twenty seven pregnant women who had been visited to Korea University Hospital for asthma worsened were enrolled in our retrospective study. We reviewed medical recordings and interviewed patients with asthma. Results: Twenty seven pregnant women with asthma were evaluated, and 25 patients were enrolled to our study. Two patients experienced abortions at 6 weeks and 25 weeks gestation, respectively. The period of asthma worsened was commonly during weeks 20 to 28 of gestation. And all patients worsened were improved during the last 4 weeks of pregnancy. Twenty (80%) of 25 women whose asthma worsened during pregnancy reverted toward their prepregnancy status after delivery (p<0.002). The causes of asthma worsened during pregnancy are reduction or even complete cessation of medication due to fears about its safety (40%), worsening after upper respiratory infection (28%), and unknown (32%). There were no adverse perinatal outcomes in 25 pregnant asthma subjects. Conclusions: A major problem of therapy for asthma during pregnancy is reduction or even complete cessation of medication due to fears of fetal effects. Therefore, maternal education and optimal clinical and pharmacologic management is necessary to mitigate maternal and fetal complications.
AB - Background: Asthma is the most common respiratory crisis encountered in clinical practice, occurring in up to 4% of all pregnancies. Pregnancy often appears to alter the course of asthma. But the mechanisms responsible for variable changes in the asthma course during pregnancy remain unknown. Poor control and exacerbations of asthma during pregnancy may result in serious maternal and fetal complications. To investigate the course of asthma during pregnancy in korean women, we did a retrograde study of 27 pregnant women who had been admitted to Korea University Hospital for asthma worsened. Method: Twenty seven pregnant women who had been visited to Korea University Hospital for asthma worsened were enrolled in our retrospective study. We reviewed medical recordings and interviewed patients with asthma. Results: Twenty seven pregnant women with asthma were evaluated, and 25 patients were enrolled to our study. Two patients experienced abortions at 6 weeks and 25 weeks gestation, respectively. The period of asthma worsened was commonly during weeks 20 to 28 of gestation. And all patients worsened were improved during the last 4 weeks of pregnancy. Twenty (80%) of 25 women whose asthma worsened during pregnancy reverted toward their prepregnancy status after delivery (p<0.002). The causes of asthma worsened during pregnancy are reduction or even complete cessation of medication due to fears about its safety (40%), worsening after upper respiratory infection (28%), and unknown (32%). There were no adverse perinatal outcomes in 25 pregnant asthma subjects. Conclusions: A major problem of therapy for asthma during pregnancy is reduction or even complete cessation of medication due to fears of fetal effects. Therefore, maternal education and optimal clinical and pharmacologic management is necessary to mitigate maternal and fetal complications.
KW - Asthma
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0032768633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032768633&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0032768633
VL - 46
SP - 548
EP - 554
JO - Tuberculosis and Respiratory Diseases
JF - Tuberculosis and Respiratory Diseases
SN - 1738-3536
IS - 4
ER -