Clinical investigation of women with asthma worsened during pregnancy

Hwan Kwon Young Hwan Kwon, Kyu Kim Kyung Kyu Kim, Cheol Jung Hye Cheol Jung, Sung Yong Lee, Je Hyeong Kim, Ra Lee So Ra Lee, Yeub Lee Sang Yeub Lee, Hyeong Lee Sin Hyeong Lee, Yun Cho Jae Yun Cho, Jeong Shim Jae Jeong Shim, Ho Kang Kyung Ho Kang, Hwa Yoo Se Hwa Yoo, Ho In Kwang Ho In

Research output: Contribution to journalArticle

Abstract

Background: Asthma is the most common respiratory crisis encountered in clinical practice, occurring in up to 4% of all pregnancies. Pregnancy often appears to alter the course of asthma. But the mechanisms responsible for variable changes in the asthma course during pregnancy remain unknown. Poor control and exacerbations of asthma during pregnancy may result in serious maternal and fetal complications. To investigate the course of asthma during pregnancy in korean women, we did a retrograde study of 27 pregnant women who had been admitted to Korea University Hospital for asthma worsened. Method: Twenty seven pregnant women who had been visited to Korea University Hospital for asthma worsened were enrolled in our retrospective study. We reviewed medical recordings and interviewed patients with asthma. Results: Twenty seven pregnant women with asthma were evaluated, and 25 patients were enrolled to our study. Two patients experienced abortions at 6 weeks and 25 weeks gestation, respectively. The period of asthma worsened was commonly during weeks 20 to 28 of gestation. And all patients worsened were improved during the last 4 weeks of pregnancy. Twenty (80%) of 25 women whose asthma worsened during pregnancy reverted toward their prepregnancy status after delivery (p<0.002). The causes of asthma worsened during pregnancy are reduction or even complete cessation of medication due to fears about its safety (40%), worsening after upper respiratory infection (28%), and unknown (32%). There were no adverse perinatal outcomes in 25 pregnant asthma subjects. Conclusions: A major problem of therapy for asthma during pregnancy is reduction or even complete cessation of medication due to fears of fetal effects. Therefore, maternal education and optimal clinical and pharmacologic management is necessary to mitigate maternal and fetal complications.

Original languageEnglish
Pages (from-to)548-554
Number of pages7
JournalTuberculosis and Respiratory Diseases
Volume46
Issue number4
Publication statusPublished - 1999 Jan 1

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Asthma
Pregnancy
Pregnant Women
Mothers
Korea
Fear
Respiratory Tract Infections
Retrospective Studies
Safety
Education

Keywords

  • Asthma
  • Pregnancy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Young Hwan Kwon, H. K., Kyung Kyu Kim, K. K., Hye Cheol Jung, C. J., Lee, S. Y., Kim, J. H., So Ra Lee, R. L., ... Kwang Ho In, H. I. (1999). Clinical investigation of women with asthma worsened during pregnancy. Tuberculosis and Respiratory Diseases, 46(4), 548-554.

Clinical investigation of women with asthma worsened during pregnancy. / Young Hwan Kwon, Hwan Kwon; Kyung Kyu Kim, Kyu Kim; Hye Cheol Jung, Cheol Jung; Lee, Sung Yong; Kim, Je Hyeong; So Ra Lee, Ra Lee; Sang Yeub Lee, Yeub Lee; Sin Hyeong Lee, Hyeong Lee; Jae Yun Cho, Yun Cho; Jae Jeong Shim, Jeong Shim; Kyung Ho Kang, Ho Kang; Se Hwa Yoo, Hwa Yoo; Kwang Ho In, Ho In.

In: Tuberculosis and Respiratory Diseases, Vol. 46, No. 4, 01.01.1999, p. 548-554.

Research output: Contribution to journalArticle

Young Hwan Kwon, HK, Kyung Kyu Kim, KK, Hye Cheol Jung, CJ, Lee, SY, Kim, JH, So Ra Lee, RL, Sang Yeub Lee, YL, Sin Hyeong Lee, HL, Jae Yun Cho, YC, Jae Jeong Shim, JS, Kyung Ho Kang, HK, Se Hwa Yoo, HY & Kwang Ho In, HI 1999, 'Clinical investigation of women with asthma worsened during pregnancy', Tuberculosis and Respiratory Diseases, vol. 46, no. 4, pp. 548-554.
Young Hwan Kwon HK, Kyung Kyu Kim KK, Hye Cheol Jung CJ, Lee SY, Kim JH, So Ra Lee RL et al. Clinical investigation of women with asthma worsened during pregnancy. Tuberculosis and Respiratory Diseases. 1999 Jan 1;46(4):548-554.
Young Hwan Kwon, Hwan Kwon ; Kyung Kyu Kim, Kyu Kim ; Hye Cheol Jung, Cheol Jung ; Lee, Sung Yong ; Kim, Je Hyeong ; So Ra Lee, Ra Lee ; Sang Yeub Lee, Yeub Lee ; Sin Hyeong Lee, Hyeong Lee ; Jae Yun Cho, Yun Cho ; Jae Jeong Shim, Jeong Shim ; Kyung Ho Kang, Ho Kang ; Se Hwa Yoo, Hwa Yoo ; Kwang Ho In, Ho In. / Clinical investigation of women with asthma worsened during pregnancy. In: Tuberculosis and Respiratory Diseases. 1999 ; Vol. 46, No. 4. pp. 548-554.
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abstract = "Background: Asthma is the most common respiratory crisis encountered in clinical practice, occurring in up to 4{\%} of all pregnancies. Pregnancy often appears to alter the course of asthma. But the mechanisms responsible for variable changes in the asthma course during pregnancy remain unknown. Poor control and exacerbations of asthma during pregnancy may result in serious maternal and fetal complications. To investigate the course of asthma during pregnancy in korean women, we did a retrograde study of 27 pregnant women who had been admitted to Korea University Hospital for asthma worsened. Method: Twenty seven pregnant women who had been visited to Korea University Hospital for asthma worsened were enrolled in our retrospective study. We reviewed medical recordings and interviewed patients with asthma. Results: Twenty seven pregnant women with asthma were evaluated, and 25 patients were enrolled to our study. Two patients experienced abortions at 6 weeks and 25 weeks gestation, respectively. The period of asthma worsened was commonly during weeks 20 to 28 of gestation. And all patients worsened were improved during the last 4 weeks of pregnancy. Twenty (80{\%}) of 25 women whose asthma worsened during pregnancy reverted toward their prepregnancy status after delivery (p<0.002). The causes of asthma worsened during pregnancy are reduction or even complete cessation of medication due to fears about its safety (40{\%}), worsening after upper respiratory infection (28{\%}), and unknown (32{\%}). There were no adverse perinatal outcomes in 25 pregnant asthma subjects. Conclusions: A major problem of therapy for asthma during pregnancy is reduction or even complete cessation of medication due to fears of fetal effects. Therefore, maternal education and optimal clinical and pharmacologic management is necessary to mitigate maternal and fetal complications.",
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AU - Kim, Je Hyeong

AU - So Ra Lee, Ra Lee

AU - Sang Yeub Lee, Yeub Lee

AU - Sin Hyeong Lee, Hyeong Lee

AU - Jae Yun Cho, Yun Cho

AU - Jae Jeong Shim, Jeong Shim

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N2 - Background: Asthma is the most common respiratory crisis encountered in clinical practice, occurring in up to 4% of all pregnancies. Pregnancy often appears to alter the course of asthma. But the mechanisms responsible for variable changes in the asthma course during pregnancy remain unknown. Poor control and exacerbations of asthma during pregnancy may result in serious maternal and fetal complications. To investigate the course of asthma during pregnancy in korean women, we did a retrograde study of 27 pregnant women who had been admitted to Korea University Hospital for asthma worsened. Method: Twenty seven pregnant women who had been visited to Korea University Hospital for asthma worsened were enrolled in our retrospective study. We reviewed medical recordings and interviewed patients with asthma. Results: Twenty seven pregnant women with asthma were evaluated, and 25 patients were enrolled to our study. Two patients experienced abortions at 6 weeks and 25 weeks gestation, respectively. The period of asthma worsened was commonly during weeks 20 to 28 of gestation. And all patients worsened were improved during the last 4 weeks of pregnancy. Twenty (80%) of 25 women whose asthma worsened during pregnancy reverted toward their prepregnancy status after delivery (p<0.002). The causes of asthma worsened during pregnancy are reduction or even complete cessation of medication due to fears about its safety (40%), worsening after upper respiratory infection (28%), and unknown (32%). There were no adverse perinatal outcomes in 25 pregnant asthma subjects. Conclusions: A major problem of therapy for asthma during pregnancy is reduction or even complete cessation of medication due to fears of fetal effects. Therefore, maternal education and optimal clinical and pharmacologic management is necessary to mitigate maternal and fetal complications.

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