Clinical manifestations and risk factors of anaphylaxis in pollen–food allergy syndrome

Work Group for Rhinitis, the Korean Academy of Asthma, Allergy and Clinical Immunology

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Many studies have reported that pollen-food allergy syndrome (PFAS) can cause anaphylaxis. No comprehensive inves-tigations into anaphylaxis in PFAS have been conducted, however. In this study, we investigated the clinical manifestations and risk factors for anaphylaxis in PFAS in Korean patients with pollinosis. Materials and Methods: Data were obtained from a nationwide cross-sectional study that previously reported on PFAS in Korean patients with pollinosis. Data from 273 patients with PFAS were collected, including demographics, list of culprit fruits and vege- tables, and clinical manifestations of food allergy. We analyzed 27 anaphylaxis patients and compared them with patients with PFAS with oropharyngeal symptoms only (n=130). Results: The most common cause of anaphylaxis in PFAS was peanut (33.3%), apple (22.2%), walnut (22.2%), pine nut (18.5%), peach (14.8%), and ginseng (14.8%). Anaphylaxis was significantly associated with the strength of sensitization to alder, hazel, willow, poplar, timothy, and ragweed (p=0.05, respectively). Multivariable analysis revealed that the presence of atopic dermatitis [odds ratio (OR), 3.58; 95% confidence interval (CI), 1.25–10.23; p=0.017]; sensitization to hazel (OR, 5.27; 95% CI, 1.79–15.53; p=0.003), timothy (OR, 11.8; 95% CI, 2.70–51.64; p=0.001), or ragweed (OR, 3.18; 95% CI, 1.03–9.87; p=0.045); and the number of culprit foods (OR, 1.25; 95% CI, 1.15–1.37; p=0.001) were related to the development of anaphylaxis in PFAS. Conclusion: The most common culprit foods causing anaphylaxis in PFAS were peanut and apple. The presence of atopic derma-titis; sensitization to hazel, timothy, or ragweed; and a greater number of culprit foods were risk factors for anaphylaxis in PFAS.

Original languageEnglish
Pages (from-to)960-968
Number of pages9
JournalYonsei medical journal
Volume60
Issue number10
DOIs
Publication statusPublished - 2019 Oct

Keywords

  • Continuous renal replacement therapy
  • Fluid overload
  • Premature infants

ASJC Scopus subject areas

  • Medicine(all)

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