Clinical manifestations of respiratory adenoviral infection among hospitalized children in Korea

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background The objective of our study was to understand the epidemiological and clinical features of respiratory adenoviral infections among children at a single institution over the course of several years. Methods From January 2005 to April 2009, 1836 children (≤15 years old) who had been admitted to Korea University Ansan Hospital were tested for acute respiratory infection. The patients who were positive for an adenovirus infection were enrolled in this study, and their medical records were retrospectively reviewed. Results Adenoviruses were isolated from 310 patients. The male to female ratio was 1.6:1 and mean age was 32 ± 24 months. Children under 5 years of age had the highest prevalence. In 2007, adenovirus infections occurred endemically throughout the year. The clinical diagnoses were primarily upper respiratory tract infections (45.4%), lower respiratory tract infections (48.1%), and neurologic disease (5.2%). Associated symptoms, signs and laboratory findings included fever (91.9%), cough (83.9%), pharyngeal injection (62.3%), rale (32.6%) and elevated C-reactive protein (93.9%). The most common radiologic findings were perihilar and peribronchial infiltrates (42.6%). Co-infections were observed in 29 cases. The mean durations of hospitalization and fever were 6.2 ± 6.5 and 4.8 ± 3.1 days, respectively. The lengths of hospitalization were similar for patients admitted for upper respiratory tract infections with severe morbidity and those admitted for lower respiratory tract infections. No children in the study died. Conclusion Our study demonstrates that respiratory adenovirus infections are an important cause of hospitalization in young children, and contribute to a significant morbidity.

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalPediatrics International
Volume55
Issue number4
DOIs
Publication statusPublished - 2013 Aug 1

Fingerprint

Hospitalized Child
Korea
Respiratory Tract Infections
Adenoviridae Infections
Hospitalization
Fever
Morbidity
Respiratory Sounds
Nervous System Diseases
Coinfection
Cough
Adenoviridae
C-Reactive Protein
Signs and Symptoms
Medical Records
Injections

Keywords

  • adenovirus
  • children
  • hospitalization
  • morbidity
  • respiratory infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{44a13b2f43ef455f8c00e1751a2ff568,
title = "Clinical manifestations of respiratory adenoviral infection among hospitalized children in Korea",
abstract = "Background The objective of our study was to understand the epidemiological and clinical features of respiratory adenoviral infections among children at a single institution over the course of several years. Methods From January 2005 to April 2009, 1836 children (≤15 years old) who had been admitted to Korea University Ansan Hospital were tested for acute respiratory infection. The patients who were positive for an adenovirus infection were enrolled in this study, and their medical records were retrospectively reviewed. Results Adenoviruses were isolated from 310 patients. The male to female ratio was 1.6:1 and mean age was 32 ± 24 months. Children under 5 years of age had the highest prevalence. In 2007, adenovirus infections occurred endemically throughout the year. The clinical diagnoses were primarily upper respiratory tract infections (45.4{\%}), lower respiratory tract infections (48.1{\%}), and neurologic disease (5.2{\%}). Associated symptoms, signs and laboratory findings included fever (91.9{\%}), cough (83.9{\%}), pharyngeal injection (62.3{\%}), rale (32.6{\%}) and elevated C-reactive protein (93.9{\%}). The most common radiologic findings were perihilar and peribronchial infiltrates (42.6{\%}). Co-infections were observed in 29 cases. The mean durations of hospitalization and fever were 6.2 ± 6.5 and 4.8 ± 3.1 days, respectively. The lengths of hospitalization were similar for patients admitted for upper respiratory tract infections with severe morbidity and those admitted for lower respiratory tract infections. No children in the study died. Conclusion Our study demonstrates that respiratory adenovirus infections are an important cause of hospitalization in young children, and contribute to a significant morbidity.",
keywords = "adenovirus, children, hospitalization, morbidity, respiratory infection",
author = "Kwon, {Hyo Jin} and Young-Jun Rhie and Seo, {Won Hee} and Giyoung Jang and Choi, {Byung Min} and Lee, {Jung Hwa} and Lee, {Chang Kyu} and Kim, {Yun Kyung}",
year = "2013",
month = "8",
day = "1",
doi = "10.1111/ped.12108",
language = "English",
volume = "55",
pages = "450--454",
journal = "Pediatrics International",
issn = "1328-8067",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Clinical manifestations of respiratory adenoviral infection among hospitalized children in Korea

AU - Kwon, Hyo Jin

AU - Rhie, Young-Jun

AU - Seo, Won Hee

AU - Jang, Giyoung

AU - Choi, Byung Min

AU - Lee, Jung Hwa

AU - Lee, Chang Kyu

AU - Kim, Yun Kyung

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Background The objective of our study was to understand the epidemiological and clinical features of respiratory adenoviral infections among children at a single institution over the course of several years. Methods From January 2005 to April 2009, 1836 children (≤15 years old) who had been admitted to Korea University Ansan Hospital were tested for acute respiratory infection. The patients who were positive for an adenovirus infection were enrolled in this study, and their medical records were retrospectively reviewed. Results Adenoviruses were isolated from 310 patients. The male to female ratio was 1.6:1 and mean age was 32 ± 24 months. Children under 5 years of age had the highest prevalence. In 2007, adenovirus infections occurred endemically throughout the year. The clinical diagnoses were primarily upper respiratory tract infections (45.4%), lower respiratory tract infections (48.1%), and neurologic disease (5.2%). Associated symptoms, signs and laboratory findings included fever (91.9%), cough (83.9%), pharyngeal injection (62.3%), rale (32.6%) and elevated C-reactive protein (93.9%). The most common radiologic findings were perihilar and peribronchial infiltrates (42.6%). Co-infections were observed in 29 cases. The mean durations of hospitalization and fever were 6.2 ± 6.5 and 4.8 ± 3.1 days, respectively. The lengths of hospitalization were similar for patients admitted for upper respiratory tract infections with severe morbidity and those admitted for lower respiratory tract infections. No children in the study died. Conclusion Our study demonstrates that respiratory adenovirus infections are an important cause of hospitalization in young children, and contribute to a significant morbidity.

AB - Background The objective of our study was to understand the epidemiological and clinical features of respiratory adenoviral infections among children at a single institution over the course of several years. Methods From January 2005 to April 2009, 1836 children (≤15 years old) who had been admitted to Korea University Ansan Hospital were tested for acute respiratory infection. The patients who were positive for an adenovirus infection were enrolled in this study, and their medical records were retrospectively reviewed. Results Adenoviruses were isolated from 310 patients. The male to female ratio was 1.6:1 and mean age was 32 ± 24 months. Children under 5 years of age had the highest prevalence. In 2007, adenovirus infections occurred endemically throughout the year. The clinical diagnoses were primarily upper respiratory tract infections (45.4%), lower respiratory tract infections (48.1%), and neurologic disease (5.2%). Associated symptoms, signs and laboratory findings included fever (91.9%), cough (83.9%), pharyngeal injection (62.3%), rale (32.6%) and elevated C-reactive protein (93.9%). The most common radiologic findings were perihilar and peribronchial infiltrates (42.6%). Co-infections were observed in 29 cases. The mean durations of hospitalization and fever were 6.2 ± 6.5 and 4.8 ± 3.1 days, respectively. The lengths of hospitalization were similar for patients admitted for upper respiratory tract infections with severe morbidity and those admitted for lower respiratory tract infections. No children in the study died. Conclusion Our study demonstrates that respiratory adenovirus infections are an important cause of hospitalization in young children, and contribute to a significant morbidity.

KW - adenovirus

KW - children

KW - hospitalization

KW - morbidity

KW - respiratory infection

UR - http://www.scopus.com/inward/record.url?scp=84881459316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881459316&partnerID=8YFLogxK

U2 - 10.1111/ped.12108

DO - 10.1111/ped.12108

M3 - Article

VL - 55

SP - 450

EP - 454

JO - Pediatrics International

JF - Pediatrics International

SN - 1328-8067

IS - 4

ER -