Clinical outcome and predictive factors of recurrence among patients with Kikuchi's disease

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Abstract

Objectives: To evaluate the clinical outcome and predictive factors of recurrence among patients with Kikuchi's disease. Methods: Between January 2001 and December 2006, all patients with Kikuchi's disease were included in the study. Data were collected on co-morbidities, clinical manifestations, and ultrasound/laboratory findings, and the differences were compared between recurrent disease and non-recurrent disease groups. Results: The study included 102 patients with a mean age of 26.7 years. Among these patients, three developed systemic lupus erythematosus during the follow-up period, while two cases were later associated with tuberculosis. Eight patients (7.8%) experienced early relapse and 13 (12.7%) showed late recurrence. Patients with recurrent episodes were more likely to have fever and fatigue with extranodal involvement. Compared to the non-recurrent cases, recurrent cases remained symptomatic for a rather longer duration. The positive rate of the fluorescence anti-nuclear antibody (FANA) test was significantly higher in the recurrent disease group compared to the non-recurrent disease group. Conclusions: Kikuchi's disease took a self-limiting clinical course in most cases, but the recurrence rate found in the present study was higher than that of previous reports. Kikuchi's disease might be a phenotype of diverse disease entities. The prognosis is different according to the underlying cause. The FANA test would be useful in predicting recurrence.

Original languageEnglish
Pages (from-to)322-326
Number of pages5
JournalInternational Journal of Infectious Diseases
Volume13
Issue number3
DOIs
Publication statusPublished - 2009 May

Keywords

  • Histiocytic necrotizing lymphadenitis
  • Prognosis
  • Recurrence

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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