Clinical outcome of successful percutaneous coronary intervention for chronic total occlusion: Results from the multicenter Korean chronic total occlusion (K-CTO) registry

Byeong Keuk Kim, Sanghoon Shin, Dong Ho Shin, Myeong Ki Hong, Hyeon Cheol Gwon, Hyo Soo Kim, Cheol Woong Yu, Hun Sik Park, In Ho Chae, Seung-Woon Rha, Seung Hwan Lee, Moo Hyun Kim, Seung Ho Hur, Yangsoo Jang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: To investigate the impact of the success or failure of chronic total occlusion (CTO) interventions on the clinical outcomes in the current drug-eluting stent (DES) era. BACKGROUND: The impact of the successful CTO intervention on long-term clinical outcomes still remains unclear. METHODS: Between 2007 and 2009, a total of 2568 patients with CTO were followed in a multicenter Korean CTO registry. Of these, successful recanalization with DESs occurred in 2045 patients (successful CTO group), whereas failure occurred in 523 patients (failed CTO group). RESULTS: The occurrence of the composite of cardiac death and myocardial infarction (MI) was compared between the successful CTO and failed CTO groups. During follow-up (median duration, 729 days), the occurrence of cardiac death or MI was significantly lower in the successful CTO group than in the failed CTO group (1.7% vs 3.3%; hazard ratio, 0.50; 95% confidence interval, 0.28-0.91; P≤.02) and the cumulative occurrence in the successful CTO group was also significantly lower than in the failed CTO group (1.7% vs 3.0%; P≤.03) by the Kaplan-Meier method. The successful CTO group had a significantly lower need for bypass surgery than the failed CTO group (0.2% vs 2.5%; P<.001). In multivariate analysis, procedural success of CTO (odds ratio, 0.51; 95% CI, 0.29-0.92) was significantly predictive of the occurrence of cardiac death or MI, together with age and left ventricular ejection fraction <40%. CONCLUSION: This registry study demonstrated that successful CTO intervention with DESs compared to failed CTO intervention was associated with lower event rates during follow-up.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalJournal of Invasive Cardiology
Volume26
Issue number6
Publication statusPublished - 2014 Jan 1

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Percutaneous Coronary Intervention
Registries
Myocardial Infarction
Drug-Eluting Stents
Stroke Volume
Multivariate Analysis
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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Clinical outcome of successful percutaneous coronary intervention for chronic total occlusion : Results from the multicenter Korean chronic total occlusion (K-CTO) registry. / Kim, Byeong Keuk; Shin, Sanghoon; Shin, Dong Ho; Hong, Myeong Ki; Gwon, Hyeon Cheol; Kim, Hyo Soo; Yu, Cheol Woong; Park, Hun Sik; Chae, In Ho; Rha, Seung-Woon; Lee, Seung Hwan; Kim, Moo Hyun; Hur, Seung Ho; Jang, Yangsoo.

In: Journal of Invasive Cardiology, Vol. 26, No. 6, 01.01.2014, p. 255-259.

Research output: Contribution to journalArticle

Kim, BK, Shin, S, Shin, DH, Hong, MK, Gwon, HC, Kim, HS, Yu, CW, Park, HS, Chae, IH, Rha, S-W, Lee, SH, Kim, MH, Hur, SH & Jang, Y 2014, 'Clinical outcome of successful percutaneous coronary intervention for chronic total occlusion: Results from the multicenter Korean chronic total occlusion (K-CTO) registry', Journal of Invasive Cardiology, vol. 26, no. 6, pp. 255-259.
Kim, Byeong Keuk ; Shin, Sanghoon ; Shin, Dong Ho ; Hong, Myeong Ki ; Gwon, Hyeon Cheol ; Kim, Hyo Soo ; Yu, Cheol Woong ; Park, Hun Sik ; Chae, In Ho ; Rha, Seung-Woon ; Lee, Seung Hwan ; Kim, Moo Hyun ; Hur, Seung Ho ; Jang, Yangsoo. / Clinical outcome of successful percutaneous coronary intervention for chronic total occlusion : Results from the multicenter Korean chronic total occlusion (K-CTO) registry. In: Journal of Invasive Cardiology. 2014 ; Vol. 26, No. 6. pp. 255-259.
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abstract = "Objectives: To investigate the impact of the success or failure of chronic total occlusion (CTO) interventions on the clinical outcomes in the current drug-eluting stent (DES) era. BACKGROUND: The impact of the successful CTO intervention on long-term clinical outcomes still remains unclear. METHODS: Between 2007 and 2009, a total of 2568 patients with CTO were followed in a multicenter Korean CTO registry. Of these, successful recanalization with DESs occurred in 2045 patients (successful CTO group), whereas failure occurred in 523 patients (failed CTO group). RESULTS: The occurrence of the composite of cardiac death and myocardial infarction (MI) was compared between the successful CTO and failed CTO groups. During follow-up (median duration, 729 days), the occurrence of cardiac death or MI was significantly lower in the successful CTO group than in the failed CTO group (1.7{\%} vs 3.3{\%}; hazard ratio, 0.50; 95{\%} confidence interval, 0.28-0.91; P≤.02) and the cumulative occurrence in the successful CTO group was also significantly lower than in the failed CTO group (1.7{\%} vs 3.0{\%}; P≤.03) by the Kaplan-Meier method. The successful CTO group had a significantly lower need for bypass surgery than the failed CTO group (0.2{\%} vs 2.5{\%}; P<.001). In multivariate analysis, procedural success of CTO (odds ratio, 0.51; 95{\%} CI, 0.29-0.92) was significantly predictive of the occurrence of cardiac death or MI, together with age and left ventricular ejection fraction <40{\%}. CONCLUSION: This registry study demonstrated that successful CTO intervention with DESs compared to failed CTO intervention was associated with lower event rates during follow-up.",
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AU - Hong, Myeong Ki

AU - Gwon, Hyeon Cheol

AU - Kim, Hyo Soo

AU - Yu, Cheol Woong

AU - Park, Hun Sik

AU - Chae, In Ho

AU - Rha, Seung-Woon

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