Clinical outcomes in patients with intermediate coronary stenoses

MINIATURE investigators (Korea multlcenter trial on long-term clinical outcome according to the plaque burden and treatment strategy in lesions with minimum lumen area less than 4 mm2 using intravascular ultrasound)

Young Joon Hong, Yun Ha Choi, Soo Young Park, Chang Wook Nam, Jang Hyun Cho, Won Yu Kang, Sang Rok Lee, Sung Yun Lee, Sang Wook Kim, Sang Yeob Lim, Kyung Ho Yun, Jung Sun Kim, Jin Won Kim, Woong Chol Kang, Ki Seok Kim, Jin Ho Choi, Joong Wha Chung, Soo Joong Kim, Youngkeun Ahn, Myung Ho Jeong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Objectives: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. Subjects and Methods: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm 2 with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). Results: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034). Conclusion: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50-70% of plaque burden.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalKorean Circulation Journal
Volume44
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

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Coronary Stenosis
Korea
Research Personnel
Odds Ratio
Myocardial Infarction
Confidence Intervals
Diabetes Mellitus
Therapeutics
Incidence
Percutaneous Coronary Intervention
Group Psychotherapy
Stents
Pathologic Constriction

Keywords

  • Atherosclerotic plaque
  • Coronary artery disease
  • Intravascular ultrasonography

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Clinical outcomes in patients with intermediate coronary stenoses : MINIATURE investigators (Korea multlcenter trial on long-term clinical outcome according to the plaque burden and treatment strategy in lesions with minimum lumen area less than 4 mm2 using intravascular ultrasound). / Hong, Young Joon; Choi, Yun Ha; Park, Soo Young; Nam, Chang Wook; Cho, Jang Hyun; Kang, Won Yu; Lee, Sang Rok; Lee, Sung Yun; Kim, Sang Wook; Lim, Sang Yeob; Yun, Kyung Ho; Kim, Jung Sun; Kim, Jin Won; Kang, Woong Chol; Kim, Ki Seok; Choi, Jin Ho; Chung, Joong Wha; Kim, Soo Joong; Ahn, Youngkeun; Jeong, Myung Ho.

In: Korean Circulation Journal, Vol. 44, No. 3, 01.01.2014, p. 148-155.

Research output: Contribution to journalArticle

Hong, Young Joon ; Choi, Yun Ha ; Park, Soo Young ; Nam, Chang Wook ; Cho, Jang Hyun ; Kang, Won Yu ; Lee, Sang Rok ; Lee, Sung Yun ; Kim, Sang Wook ; Lim, Sang Yeob ; Yun, Kyung Ho ; Kim, Jung Sun ; Kim, Jin Won ; Kang, Woong Chol ; Kim, Ki Seok ; Choi, Jin Ho ; Chung, Joong Wha ; Kim, Soo Joong ; Ahn, Youngkeun ; Jeong, Myung Ho. / Clinical outcomes in patients with intermediate coronary stenoses : MINIATURE investigators (Korea multlcenter trial on long-term clinical outcome according to the plaque burden and treatment strategy in lesions with minimum lumen area less than 4 mm2 using intravascular ultrasound). In: Korean Circulation Journal. 2014 ; Vol. 44, No. 3. pp. 148-155.
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abstract = "Background and Objectives: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. Subjects and Methods: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70{\%}) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm 2 with 50-70{\%} plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). Results: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3{\%} vs. 3.0{\%}, p=0.471), target vessel-related non-fatal myocardial infarction (0.0{\%} vs. 0.0{\%}, p=1.000) and target vessel revascularizations (7.8{\%} vs. 4.5{\%}, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95{\%} confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95{\%} CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95{\%} CI 1.18-5.24, p=0.034). Conclusion: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50-70{\%} of plaque burden.",
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author = "Hong, {Young Joon} and Choi, {Yun Ha} and Park, {Soo Young} and Nam, {Chang Wook} and Cho, {Jang Hyun} and Kang, {Won Yu} and Lee, {Sang Rok} and Lee, {Sung Yun} and Kim, {Sang Wook} and Lim, {Sang Yeob} and Yun, {Kyung Ho} and Kim, {Jung Sun} and Kim, {Jin Won} and Kang, {Woong Chol} and Kim, {Ki Seok} and Choi, {Jin Ho} and Chung, {Joong Wha} and Kim, {Soo Joong} and Youngkeun Ahn and Jeong, {Myung Ho}",
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T1 - Clinical outcomes in patients with intermediate coronary stenoses

T2 - MINIATURE investigators (Korea multlcenter trial on long-term clinical outcome according to the plaque burden and treatment strategy in lesions with minimum lumen area less than 4 mm2 using intravascular ultrasound)

AU - Hong, Young Joon

AU - Choi, Yun Ha

AU - Park, Soo Young

AU - Nam, Chang Wook

AU - Cho, Jang Hyun

AU - Kang, Won Yu

AU - Lee, Sang Rok

AU - Lee, Sung Yun

AU - Kim, Sang Wook

AU - Lim, Sang Yeob

AU - Yun, Kyung Ho

AU - Kim, Jung Sun

AU - Kim, Jin Won

AU - Kang, Woong Chol

AU - Kim, Ki Seok

AU - Choi, Jin Ho

AU - Chung, Joong Wha

AU - Kim, Soo Joong

AU - Ahn, Youngkeun

AU - Jeong, Myung Ho

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background and Objectives: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. Subjects and Methods: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm 2 with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). Results: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034). Conclusion: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50-70% of plaque burden.

AB - Background and Objectives: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. Subjects and Methods: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm 2 with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). Results: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034). Conclusion: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50-70% of plaque burden.

KW - Atherosclerotic plaque

KW - Coronary artery disease

KW - Intravascular ultrasonography

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DO - 10.4070/kcj.2014.44.3.148

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JO - Korean Circulation Journal

JF - Korean Circulation Journal

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