Clinical outcomes in patients with intermediate coronary stenoses: MINIATURE investigators (Korea multlcenter trial on long-term clinical outcome according to the plaque burden and treatment strategy in lesions with minimum lumen area less than 4 mm2 using intravascular ultrasound)

Young Joon Hong, Yun Ha Choi, Soo Young Park, Chang Wook Nam, Jang Hyun Cho, Won Yu Kang, Sang Rok Lee, Sung Yun Lee, Sang Wook Kim, Sang Yeob Lim, Kyung Ho Yun, Jung Sun Kim, Jin Won Kim, Woong Chol Kang, Ki Seok Kim, Jin Ho Choi, Joong Wha Chung, Soo Joong Kim, Youngkeun Ahn, Myung Ho Jeong

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Abstract

Background and Objectives: We evaluated the two-year clinical outcomes in patients with angiographically intermediate lesions according to the plaque burden and treatment strategy. Subjects and Methods: We prospectively enrolled patients with angiographically intermediate lesions (diameter stenosis 30-70%) with an intravascular ultrasound (IVUS) minimum lumen area (MLA) <4 mm 2 with 50-70% plaque burden of 16 Korean percutaneous coronary intervention centers. Patients were divided into medical therapy group (n=85) and zotarolimus-eluting stent group (ZES; Resolute) group (n=74). We evaluated the incidences of two-year major adverse cardiovascular events (MACE). Results: A two-year clinical follow-up was completed in 143 patients and MACE occurred in 12 patients. There were no significant differences in the incidences of death (1.3% vs. 3.0%, p=0.471), target vessel-related non-fatal myocardial infarction (0.0% vs. 0.0%, p=1.000) and target vessel revascularizations (7.8% vs. 4.5%, p=0.425) between medical and ZES groups. Independent predictors of two-year MACE included acute myocardial infarction {odds ratio (OR)=2.87; 95% confidence interval (CI) 1.43-6.12, p=0.014}, diabetes mellitus (OR=2.46; 95% CI 1.24-5.56, p=0.028) and non-statin therapy (OR=2.32; 95% CI 1.18-5.24, p=0.034). Conclusion: Medical therapy shows comparable results with ZES, and myocardial infarction, diabetes mellitus and non-statin therapy were associated with the occurrence of two-year MACE in patients with intermediate lesion with IVUS MLA <4 mm2 with 50-70% of plaque burden.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalKorean Circulation Journal
Volume44
Issue number3
DOIs
Publication statusPublished - 2014 Jan 1

Keywords

  • Atherosclerotic plaque
  • Coronary artery disease
  • Intravascular ultrasonography

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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    Hong, Y. J., Choi, Y. H., Park, S. Y., Nam, C. W., Cho, J. H., Kang, W. Y., Lee, S. R., Lee, S. Y., Kim, S. W., Lim, S. Y., Yun, K. H., Kim, J. S., Kim, J. W., Kang, W. C., Kim, K. S., Choi, J. H., Chung, J. W., Kim, S. J., Ahn, Y., & Jeong, M. H. (2014). Clinical outcomes in patients with intermediate coronary stenoses: MINIATURE investigators (Korea multlcenter trial on long-term clinical outcome according to the plaque burden and treatment strategy in lesions with minimum lumen area less than 4 mm2 using intravascular ultrasound). Korean Circulation Journal, 44(3), 148-155. https://doi.org/10.4070/kcj.2014.44.3.148