Abstract
Purpose: No guidelines exist detailing when to implement a temporary ileostomy closure in the setting of adjuvant chemotherapy following sphincter-saving surgery for rectal cancer. The aim of this study was to evaluate the clinical and oncological outcomes of ileostomy closure during adjuvant chemotherapy in patients with curative resection of rectal cancer. Methods: This retrospective study investigated 220 patients with rectal cancer undergoing sphincter-saving surgery with protective loop ileostomy from January 2007 to August 2016. Patients were divided into 2 groups: group 1 (n = 161) who underwent stoma closure during adjuvant chemotherapy and group 2 (n = 59) who underwent stoma closure after adjuvant chemotherapy. Results: No significant differences were observed in operative time, blood loss, postoperative hospital stay, or postoperative complications in ileostomy closure between the 2 groups. No difference in overall survival (P = 0.959) or disease-free survival (P = 0.114) was observed between the 2 groups. Conclusion: Ileostomy closure during adjuvant chemotherapy was clinically safe, and interruption of chemotherapy due to ileostomy closure did not change oncologic outcomes.
| Original language | English |
|---|---|
| Pages (from-to) | 187-193 |
| Number of pages | 7 |
| Journal | Annals of Coloproctology |
| Volume | 35 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
Keywords
- Adjuvant chemotherapy
- Ileostomy
- Rectal neoplasms
ASJC Scopus subject areas
- Gastroenterology
Cite this
Clinical outcomes of ileostomy closure according to timing during adjuvant chemotherapy after rectal cancer surgery. / Choi, Yoo Jin; Kwak, Jung Myun; Ha, Neul; Lee, Tae Hoon; Baek, Se Jin; Kim, Jin; Kim, Seon Hahn.
In: Annals of Coloproctology, Vol. 35, No. 4, 01.01.2019, p. 187-193.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical outcomes of ileostomy closure according to timing during adjuvant chemotherapy after rectal cancer surgery
AU - Choi, Yoo Jin
AU - Kwak, Jung Myun
AU - Ha, Neul
AU - Lee, Tae Hoon
AU - Baek, Se Jin
AU - Kim, Jin
AU - Kim, Seon Hahn
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose: No guidelines exist detailing when to implement a temporary ileostomy closure in the setting of adjuvant chemotherapy following sphincter-saving surgery for rectal cancer. The aim of this study was to evaluate the clinical and oncological outcomes of ileostomy closure during adjuvant chemotherapy in patients with curative resection of rectal cancer. Methods: This retrospective study investigated 220 patients with rectal cancer undergoing sphincter-saving surgery with protective loop ileostomy from January 2007 to August 2016. Patients were divided into 2 groups: group 1 (n = 161) who underwent stoma closure during adjuvant chemotherapy and group 2 (n = 59) who underwent stoma closure after adjuvant chemotherapy. Results: No significant differences were observed in operative time, blood loss, postoperative hospital stay, or postoperative complications in ileostomy closure between the 2 groups. No difference in overall survival (P = 0.959) or disease-free survival (P = 0.114) was observed between the 2 groups. Conclusion: Ileostomy closure during adjuvant chemotherapy was clinically safe, and interruption of chemotherapy due to ileostomy closure did not change oncologic outcomes.
AB - Purpose: No guidelines exist detailing when to implement a temporary ileostomy closure in the setting of adjuvant chemotherapy following sphincter-saving surgery for rectal cancer. The aim of this study was to evaluate the clinical and oncological outcomes of ileostomy closure during adjuvant chemotherapy in patients with curative resection of rectal cancer. Methods: This retrospective study investigated 220 patients with rectal cancer undergoing sphincter-saving surgery with protective loop ileostomy from January 2007 to August 2016. Patients were divided into 2 groups: group 1 (n = 161) who underwent stoma closure during adjuvant chemotherapy and group 2 (n = 59) who underwent stoma closure after adjuvant chemotherapy. Results: No significant differences were observed in operative time, blood loss, postoperative hospital stay, or postoperative complications in ileostomy closure between the 2 groups. No difference in overall survival (P = 0.959) or disease-free survival (P = 0.114) was observed between the 2 groups. Conclusion: Ileostomy closure during adjuvant chemotherapy was clinically safe, and interruption of chemotherapy due to ileostomy closure did not change oncologic outcomes.
KW - Adjuvant chemotherapy
KW - Ileostomy
KW - Rectal neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85073393084&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073393084&partnerID=8YFLogxK
U2 - 10.3393/ac.2018.10.18.1
DO - 10.3393/ac.2018.10.18.1
M3 - Article
AN - SCOPUS:85073393084
VL - 35
SP - 187
EP - 193
JO - Annals of Coloproctology
JF - Annals of Coloproctology
SN - 2287-9714
IS - 4
ER -