Clinical outcomes of immunocompromised patients on extracorporeal membrane oxygenation support for severe acute respiratory failure

Soo Jin Na, So Hee Park, Sang Bum Hong, Woo Hyun Cho, Sang Min Lee, Young Jae Cho, Sunghoon Park, So My Koo, Seung Yong Park, Youjin Chang, Byung Ju Kang, Jung Hyun Kim, Jin Young Oh, Jae Seung Jung, Jung Wan Yoo, Yun Su Sim, Kyeongman Jeon

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: There are limited data regarding extracorporeal membrane oxygenation (ECMO) support in immunocompromised patients, despite an increase in ECMO use in patients with respiratory failure. The aim of this study was to investigate the clinical characteristics and outcomes of immunocompromised patients requiring ECMO support for severe acute respiratory failure. METHODS: Between January 2012 and December 2015, all consecutive adult patients with severe acute respiratory failure who underwent ECMO for respiratory support at 16 tertiary or university-affiliated hospitals in South Korea were enrolled retrospectively. The patients were divided into 2 groups based on the immunocompromised status at the time of ECMO initiation. In-hospital and 6-month mortalities were compared between the 2 groups. In addition, association of immunocompromised status with 6-month mortality was evaluated with logistic regression analysis. RESULTS: Among 461 patients, 118 (25.6%) were immunocompromised. Immunocompromised patients were younger and had lower haemoglobin and platelet counts than immunocompetent patients. Ventilatory parameters and the use of adjunctive/rescue therapies were similar between the 2 groups, but prone positioning was more commonly used in immunocompetent patients. Successful weaning rates from ECMO (46.6% vs 58.9%; P = 0.021) was lower and hospital mortality (66.1% vs 59.8%; P = 0.22) was higher in immunocompromised patients. In addition, immunocompromised status was associated with higher 6-month mortality (74.6% vs 64.7%, adjusted odds ratio 2.10, 95% confidence interval 1.02-4.35; P = 0.045). CONCLUSIONS: Immunocompromised patients treated with ECMO support for severe acute respiratory failure had poorer short- and long-term prognoses than did immunocompetent patients.

Original languageEnglish
Pages (from-to)788-795
Number of pages8
JournalEuropean Journal of Cardio-thoracic Surgery
Volume57
Issue number4
DOIs
Publication statusPublished - 2020 Apr 1

Keywords

  • Acute respiratory failure
  • Extracorporeal membrane oxygenation
  • Immunocompromised
  • Outcomes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Na, S. J., Park, S. H., Hong, S. B., Cho, W. H., Lee, S. M., Cho, Y. J., Park, S., Koo, S. M., Park, S. Y., Chang, Y., Kang, B. J., Kim, J. H., Oh, J. Y., Jung, J. S., Yoo, J. W., Sim, Y. S., & Jeon, K. (2020). Clinical outcomes of immunocompromised patients on extracorporeal membrane oxygenation support for severe acute respiratory failure. European Journal of Cardio-thoracic Surgery, 57(4), 788-795. https://doi.org/10.1093/ejcts/ezz276