Clinical outcomes of kidney transplantation in older end-stage renal disease patients: A nationwide cohort study

the Korean Organ Transplantation Registry Study Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients. Methods: We compared the incidence of biopsy-proven acute rejection, death-censored allograft survival and all-cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients. Results: A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age >60 years (n = 356), and recipients aged <60 years were defined as young recipients (n = 4610). The incidence of biopsy-proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death-censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living donor KT group. Conclusions: In conclusion, KT in elderly recipients might be associated with poor allograft or patient survival in general, and especially, desensitization therapy carried out in these patients might increase the risk of patient mortality. Geriatr Gerontol Int 2019; 19: 392–398.

Original languageEnglish
Pages (from-to)392-398
Number of pages7
JournalGeriatrics and Gerontology International
Volume19
Issue number5
DOIs
Publication statusPublished - 2019 May 1

Fingerprint

Kidney Transplantation
Chronic Kidney Failure
Cohort Studies
recipient
Disease
Allografts
Living Donors
psychotherapy
death
sensitization
Tissue Donors
Biopsy
Mortality
Incidence
Organ Transplantation
incidence
mortality
Registries
Survival
Group

Keywords

  • desensitization
  • elderly
  • kidney transplantation
  • patient mortality
  • sensitization

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Clinical outcomes of kidney transplantation in older end-stage renal disease patients : A nationwide cohort study. / the Korean Organ Transplantation Registry Study Group.

In: Geriatrics and Gerontology International, Vol. 19, No. 5, 01.05.2019, p. 392-398.

Research output: Contribution to journalArticle

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abstract = "Aim: The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients. Methods: We compared the incidence of biopsy-proven acute rejection, death-censored allograft survival and all-cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients. Results: A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age >60 years (n = 356), and recipients aged <60 years were defined as young recipients (n = 4610). The incidence of biopsy-proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death-censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living donor KT group. Conclusions: In conclusion, KT in elderly recipients might be associated with poor allograft or patient survival in general, and especially, desensitization therapy carried out in these patients might increase the risk of patient mortality. Geriatr Gerontol Int 2019; 19: 392–398.",
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AU - the Korean Organ Transplantation Registry Study Group

AU - Ko, Eun Jeong

AU - Yang, Jaeseok

AU - Ahn, Curie

AU - Kim, Myoung Soo

AU - Han, Duck Jong

AU - Kim, Sung Joo

AU - Yang, Chul Woo

AU - Chung, Byung Ha

AU - Ahn, Curie

AU - Chae, Dong Wan

AU - Yang, Jaeseok

AU - Choi, Bum Soon

AU - Jung, Cheol Woong

AU - Kim, Myoung Soo

AU - Kwon, Oh Jung

AU - Kim, Sung Joo

AU - Kim, Yeong Hoon

AU - Choi, Soo Jin Na

AU - Han, Seung Yeup

AU - Han, Duck Jong

AU - Lee, Sang Ho

AU - Jeong, Kyung Hwan

AU - Kim, Seung Jung

AU - Jeon, Jin Seok

AU - Park, Yeon Ho

AU - Roh, Young Nam

AU - Lee, Jeong Joon

AU - Lee, Kang Wook

AU - Han, Seung Yeup

AU - Kim, Chan Duck

AU - Park, Jong Won

AU - Kim, Joong Kyung

AU - Lee, Dong Ryeol

AU - Lee, Dong Won

AU - Seong, Eun Young

AU - Kong, Jin Min

AU - Cho, Hong Rae

AU - Park, Sung Kwang

AU - Lee, Sam Yeol

AU - Park, Jung Hwan

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N2 - Aim: The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients. Methods: We compared the incidence of biopsy-proven acute rejection, death-censored allograft survival and all-cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients. Results: A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age >60 years (n = 356), and recipients aged <60 years were defined as young recipients (n = 4610). The incidence of biopsy-proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death-censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living donor KT group. Conclusions: In conclusion, KT in elderly recipients might be associated with poor allograft or patient survival in general, and especially, desensitization therapy carried out in these patients might increase the risk of patient mortality. Geriatr Gerontol Int 2019; 19: 392–398.

AB - Aim: The aim of the present study was to investigate the clinical outcomes of kidney transplantation (KT) in elderly recipients compared with those in young recipients. Methods: We compared the incidence of biopsy-proven acute rejection, death-censored allograft survival and all-cause mortality, and also compared the impact of high sensitization or desensitization on the clinical outcomes of elderly and young recipients. Results: A total of 4966 KT recipients from the Korean Organ Transplantation Registry were included. The definition of elderly recipients was based on age >60 years (n = 356), and recipients aged <60 years were defined as young recipients (n = 4610). The incidence of biopsy-proven acute rejection did not differ between the two groups irrespective of the donor type; however, the impact of high sensitization was significant only in young recipients. Being an elderly recipient was an independent risk factor for death-censored allograft failure in terms of overall and living donor KT, but not with deceased donor KT. In regard to patient death, being an elderly recipient was a significant predictor in general and in the two subgroups, and desensitization showed a significant interaction with death in the elderly recipients in the living donor KT group. Conclusions: In conclusion, KT in elderly recipients might be associated with poor allograft or patient survival in general, and especially, desensitization therapy carried out in these patients might increase the risk of patient mortality. Geriatr Gerontol Int 2019; 19: 392–398.

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KW - elderly

KW - kidney transplantation

KW - patient mortality

KW - sensitization

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