Clinical outcomes of the intra-aortic balloon pump for resuscitated patients with acute myocardial infarction complicated by cardiac arrest

and other Korea Acute Myocardial Infarction Registry Investigators, Korea Acute Myocardial infarction Registry (KAMIR) Study Group of Korean Circulation Society

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The aim of this study was to investigate the clinical effects of intra-aortic balloon pump (IABP) in patients who received cardiopulmonary resuscitation (CPR) before procedure. Methods and results: Between November 2005 and April 2014, 49,542 patients were enrolled in a prospective cohort study for acute myocardial infarction (AMI) in Korea (KAMIR). CPR was performed in 1700 patients with cardiac arrest. Patients were excluded from the study if they had not undergone a coronary angiogram, if extracorporeal membrane oxygenation or thrombolysis was performed, and if mechanical complications presented. The primary end point was 1-month all-cause mortality. A total of 883 patients in the IABP group and 476 in the control group were included. During the 1-month follow-up, all-cause death occurred in 749 patients (55.1%). The IABP group was predominantly male and had a higher prevalence of ST-segment elevation MI and a higher risk of coronary lesions including left main disease and three-vessel disease. Glycoprotein IIb/IIIa inhibitor was administered less in the non-IABP group. In the total population, the IABP group had worse outcomes in terms of mortality rates after multivariate analysis [hazard ratio (HR) 1.22, 95% confidence interval (CI) 1.02-1.47, p = 0.034] without increasing the incidence of recurrent MI, stroke, and major bleeding. After propensity matching with a pair of 452 patients, no significant differences were observed in baseline characteristics or clinical outcomes (HR 1.21, 95% CI 0.93-1.57, p = 0.158). Conclusion: The use of IABP did not show clinical benefits in patients with AMI complicated by severe cardiogenic shock after propensity matching analysis.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalJournal of Cardiology
Volume67
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

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Heart Arrest
Myocardial Infarction
Cardiopulmonary Resuscitation
Confidence Intervals
Extracorporeal Membrane Oxygenation
Platelet Glycoprotein GPIIb-IIIa Complex
Cardiogenic Shock
Mortality
Korea
Cause of Death
Angiography
Cohort Studies
Multivariate Analysis
Stroke
Prospective Studies
Hemorrhage
Control Groups
Incidence
Population

Keywords

  • Cardiogenic shock
  • Intra-aortic balloon pump
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

and other Korea Acute Myocardial Infarction Registry Investigators, & Korea Acute Myocardial infarction Registry (KAMIR) Study Group of Korean Circulation Society (2016). Clinical outcomes of the intra-aortic balloon pump for resuscitated patients with acute myocardial infarction complicated by cardiac arrest. Journal of Cardiology, 67(1), 57-63. https://doi.org/10.1016/j.jjcc.2015.04.007

Clinical outcomes of the intra-aortic balloon pump for resuscitated patients with acute myocardial infarction complicated by cardiac arrest. / and other Korea Acute Myocardial Infarction Registry Investigators; Korea Acute Myocardial infarction Registry (KAMIR) Study Group of Korean Circulation Society.

In: Journal of Cardiology, Vol. 67, No. 1, 01.01.2016, p. 57-63.

Research output: Contribution to journalArticle

and other Korea Acute Myocardial Infarction Registry Investigators & Korea Acute Myocardial infarction Registry (KAMIR) Study Group of Korean Circulation Society 2016, 'Clinical outcomes of the intra-aortic balloon pump for resuscitated patients with acute myocardial infarction complicated by cardiac arrest', Journal of Cardiology, vol. 67, no. 1, pp. 57-63. https://doi.org/10.1016/j.jjcc.2015.04.007
and other Korea Acute Myocardial Infarction Registry Investigators, Korea Acute Myocardial infarction Registry (KAMIR) Study Group of Korean Circulation Society. Clinical outcomes of the intra-aortic balloon pump for resuscitated patients with acute myocardial infarction complicated by cardiac arrest. Journal of Cardiology. 2016 Jan 1;67(1):57-63. https://doi.org/10.1016/j.jjcc.2015.04.007
and other Korea Acute Myocardial Infarction Registry Investigators ; Korea Acute Myocardial infarction Registry (KAMIR) Study Group of Korean Circulation Society. / Clinical outcomes of the intra-aortic balloon pump for resuscitated patients with acute myocardial infarction complicated by cardiac arrest. In: Journal of Cardiology. 2016 ; Vol. 67, No. 1. pp. 57-63.
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T1 - Clinical outcomes of the intra-aortic balloon pump for resuscitated patients with acute myocardial infarction complicated by cardiac arrest

AU - and other Korea Acute Myocardial Infarction Registry Investigators

AU - Korea Acute Myocardial infarction Registry (KAMIR) Study Group of Korean Circulation Society

AU - Kim, Hyun Kuk

AU - Jeong, Myung Ho

AU - Ahn, Youngkeun

AU - Sim, Doo Sun

AU - Chae, Shung Chull

AU - Kim, Young Jo

AU - Hur, Seung Ho

AU - Seong, In Whan

AU - Hong, Taek Jong

AU - Choi, Dong Hoon

AU - Cho, Myeong Chan

AU - Kim, Chong Jin

AU - Seung, Ki Bae

AU - Jang, Yang Soo

AU - Rha, Seung-Woon

AU - Bae, Jang Ho

AU - Cho, Jeong Gwan

AU - Park, Seung Jung

AU - Kim, Jong Hyun

AU - Chae, Jei Keon

AU - Rhew, Jae Young

AU - Kim, Doo Il

AU - Chae, In Ho

AU - Yoon, Jung Han

AU - Koo, Bon Kwon

AU - Kim, Byung Ok

AU - Lee, Myoung Yong

AU - Kim, Kee Sik

AU - Hwang, Jin Yong

AU - Oh, Seok Kyu

AU - Lee, Nae Hee

AU - Jeong, Kyoung Tae

AU - Tahk, Seung Jea

AU - Park, Keum Soo

AU - Han, Kyoo Rok

AU - Ahn, Tae Hoon

AU - Kim, Moo Hyun

AU - Yang, Joo Young

AU - Rhim, Chong Yun

AU - Gwon, Hyeon Cheol

AU - Park, Seong Wook

AU - Koh, Young Youp

AU - Joo, Seung Jae

AU - Kim, Soo Joong

AU - Jin, Dong Kyu

AU - Cho, Jin Man

AU - Chung, Wook Sung

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: The aim of this study was to investigate the clinical effects of intra-aortic balloon pump (IABP) in patients who received cardiopulmonary resuscitation (CPR) before procedure. Methods and results: Between November 2005 and April 2014, 49,542 patients were enrolled in a prospective cohort study for acute myocardial infarction (AMI) in Korea (KAMIR). CPR was performed in 1700 patients with cardiac arrest. Patients were excluded from the study if they had not undergone a coronary angiogram, if extracorporeal membrane oxygenation or thrombolysis was performed, and if mechanical complications presented. The primary end point was 1-month all-cause mortality. A total of 883 patients in the IABP group and 476 in the control group were included. During the 1-month follow-up, all-cause death occurred in 749 patients (55.1%). The IABP group was predominantly male and had a higher prevalence of ST-segment elevation MI and a higher risk of coronary lesions including left main disease and three-vessel disease. Glycoprotein IIb/IIIa inhibitor was administered less in the non-IABP group. In the total population, the IABP group had worse outcomes in terms of mortality rates after multivariate analysis [hazard ratio (HR) 1.22, 95% confidence interval (CI) 1.02-1.47, p = 0.034] without increasing the incidence of recurrent MI, stroke, and major bleeding. After propensity matching with a pair of 452 patients, no significant differences were observed in baseline characteristics or clinical outcomes (HR 1.21, 95% CI 0.93-1.57, p = 0.158). Conclusion: The use of IABP did not show clinical benefits in patients with AMI complicated by severe cardiogenic shock after propensity matching analysis.

AB - Background: The aim of this study was to investigate the clinical effects of intra-aortic balloon pump (IABP) in patients who received cardiopulmonary resuscitation (CPR) before procedure. Methods and results: Between November 2005 and April 2014, 49,542 patients were enrolled in a prospective cohort study for acute myocardial infarction (AMI) in Korea (KAMIR). CPR was performed in 1700 patients with cardiac arrest. Patients were excluded from the study if they had not undergone a coronary angiogram, if extracorporeal membrane oxygenation or thrombolysis was performed, and if mechanical complications presented. The primary end point was 1-month all-cause mortality. A total of 883 patients in the IABP group and 476 in the control group were included. During the 1-month follow-up, all-cause death occurred in 749 patients (55.1%). The IABP group was predominantly male and had a higher prevalence of ST-segment elevation MI and a higher risk of coronary lesions including left main disease and three-vessel disease. Glycoprotein IIb/IIIa inhibitor was administered less in the non-IABP group. In the total population, the IABP group had worse outcomes in terms of mortality rates after multivariate analysis [hazard ratio (HR) 1.22, 95% confidence interval (CI) 1.02-1.47, p = 0.034] without increasing the incidence of recurrent MI, stroke, and major bleeding. After propensity matching with a pair of 452 patients, no significant differences were observed in baseline characteristics or clinical outcomes (HR 1.21, 95% CI 0.93-1.57, p = 0.158). Conclusion: The use of IABP did not show clinical benefits in patients with AMI complicated by severe cardiogenic shock after propensity matching analysis.

KW - Cardiogenic shock

KW - Intra-aortic balloon pump

KW - Myocardial infarction

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