Clinical phenotype of drug-naïve Parkinson's disease based on nonmotor symptoms

Hye Mi Lee, Seung Soo Lee, Minjik Kim, Sung Hoon Kang, Woo Keun Seo, Ji Hyun Kim, Seong Beom Koh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Nonmotor symptoms in Parkinson's disease (PD) are heterogeneous and can result in a variety of symptoms at various disease stages. The objective of the present study was to identify clinically meaningful nonmotor symptoms and to assess the relationship between changes in nonmotor symptoms and cognition and motor symptoms. Methods: A total of 159 patients who had drug-naïve PD participated in this study. Nonmotor symptoms (Nonmotor Symptoms Scale), PD status (Unified Parkinson's Disease Rating Scale), depression (Geriatric Depression Scale or Montgomery-Asberg Depression Scale) and health-related quality of life (39-item Parkinson's Disease Questionnaire) were assessed. An exploratory factor analysis was performed to establish a nonmotor symptom factor, which was analyzed to evaluate whether the results were associated with the clinical severity measures. Results: Exploratory factor analysis revealed one factor comprised of sleep/fatigue, attention/memory and mood/cognition. The modified Hoehn and Yahr Stage, Unified Parkinson's Disease Rating Scale Part III, Montgomery-Asberg Depression Scale and the 39-item Parkinson's Disease Questionnaire Summary Index were independently associated with the sleep/fatigue, attention/memory and mood/cognition domains. The presence of these domains was associated with advanced Parkinson's disease or depressed mood. Conclusions: This study shows that motor impairment and depressed mood in PD are related to sleep/fatigue, attention/memory and mood/cognition. Sleep/fatigue, attention/memory and mood/cognition also had a major impact on health-related quality of life. It is appropriate to identify patients with severe motor symptoms and depressed mood in order to signify the need to consider more detailed care and further assessment.

Original languageEnglish
Pages (from-to)517-522
Number of pages6
JournalArchives of Gerontology and Geriatrics
Volume61
Issue number3
DOIs
Publication statusPublished - 2015 Nov 1

Fingerprint

Parkinson Disease
drug
Disease
mood
Phenotype
Cognition
Pharmaceutical Preparations
cognition
sleep
Fatigue
fatigue
Sleep
Depression
rating scale
Statistical Factor Analysis
factor analysis
quality of life
Quality of Life
questionnaire
geriatrics

Keywords

  • Attention
  • Exploratory factor analysis
  • Mood
  • Nonmotor symptoms
  • Parkinson's disease
  • Sleep

ASJC Scopus subject areas

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Clinical phenotype of drug-naïve Parkinson's disease based on nonmotor symptoms. / Lee, Hye Mi; Lee, Seung Soo; Kim, Minjik; Kang, Sung Hoon; Seo, Woo Keun; Kim, Ji Hyun; Koh, Seong Beom.

In: Archives of Gerontology and Geriatrics, Vol. 61, No. 3, 01.11.2015, p. 517-522.

Research output: Contribution to journalArticle

Lee, Hye Mi ; Lee, Seung Soo ; Kim, Minjik ; Kang, Sung Hoon ; Seo, Woo Keun ; Kim, Ji Hyun ; Koh, Seong Beom. / Clinical phenotype of drug-naïve Parkinson's disease based on nonmotor symptoms. In: Archives of Gerontology and Geriatrics. 2015 ; Vol. 61, No. 3. pp. 517-522.
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