Clinical practice guidelines for the management of atypical hemolytic uremic syndrome in Korea

Hae Il Cheong, Sang Kyung Jo, Sung Soo Yoon, Heeyeon Cho, Jin Seok Kim, Young Ok Kim, Ja Ryong Koo, Yong Park, Young Seo Park, Jae Il Shin, Kee Hwan Yoo, Doyeun Oh

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Atypical hemolytic uremic syndrome (aHUS) is a rare syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. The major pathogenesis of aHUS involves dysregulation of the complement system. Eculizumab, which blocks complement C5 activation, has recently been proven as an effective agent. Delayed diagnosis and treatment of aHUS can cause death or end-stage renal disease. Therefore, a diagnosis that differentiates aHUS from other forms of thrombotic microangiopathy is very important for appropriate management. These guidelines aim to offer recommendations for the diagnosis and treatment of patients with aHUS in Korea. The guidelines have largely been adopted from the current guidelines due to the lack of evidence concerning the Korean population.

    Original languageEnglish
    Pages (from-to)1516-1528
    Number of pages13
    JournalJournal of Korean medical science
    Volume31
    Issue number10
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Atypical hemolytic uremic syndrome
    • Diagnosis
    • Guidelines
    • Treatment

    ASJC Scopus subject areas

    • Medicine(all)

    Fingerprint

    Dive into the research topics of 'Clinical practice guidelines for the management of atypical hemolytic uremic syndrome in Korea'. Together they form a unique fingerprint.

    Cite this