Clinical Predictors Implicated in the Incidence of Acute Pyelonephritis during the Antepartum Period: A Population-Based Cohort Study

Gang Jee Ko, Shin Young Ahn, Ji Eun Kim, Eun Jung Cho, Kyu Min Lee, Ho Yeon Kim, Young Joo Kwon, Min Jeong Oh, Sung Won Han, Geum Joon Cho

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Introduction: Acute pyelonephritis (APN) is a common infection during pregnancy that increases the risk of unfavorable maternal and fetal outcomes. However, it has not been clearly elucidated which demographic and clinical characteristics are associated with the incidence of APN during pregnancy. Objective: This population-based cohort study aimed to determine the risk factors for APN during pregnancy. Methods: Using the database of the Health Insurance Review and Assessment Service of South Korea, we enrolled Korean women who delivered infants between 2010 and 2014 in Korea and had complete health examination records within 1 year of pregnancy. We performed multivariate logistic regression analysis to evaluate the risk factors for APN during pregnancy. Results: Of 370,248 women, 2,526 (0.7% of the total participants) were treated for APN while in hospitalization during pregnancy. Younger age, history of previous APN within 1 year of pregnancy, and abnormal results of health examination before pregnancy, such as high fasting glucose level (>100 mg/dL) and proteinuria, were associated with an increased risk of APN during pregnancy. Conclusion: Certain maternal demographic and clinical characteristics were associated with the incidence of APN during pregnancy, and these should be monitored closely during antenatal care.

Original languageEnglish
JournalKidney and Blood Pressure Research
Publication statusAccepted/In press - 2019 Jan 1



  • Acute pyelonephritis
  • Antenatal care
  • Proteinuria
  • Risk factors

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine

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