Clinical significance of 5-fluorouracil chemosensitivity testing in patients with colorectal cancer

Woong Bae Ji, Jun Won Um, Je Seock Ryu, Kwang Dae Hong, Jung Sik Kim, Byung Wook Min, Sung Yeop Joung, Ju-Han Lee, Young Sik Kim

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6 Citations (Scopus)

Abstract

Aim: To evaluate whether the results of chemosensitivity testing were associated with prognosis of colorectal cancer patients after adjuvant 5-fluorouracil (FU)/ leucovorin chemotherapy. Patients and Methods: Eighty-nine patients who received 5-FU/leucovorin adjuvant chemotherapy for colorectal cancer were enrolled. Chemosensitivity tests were performed and tumor growth inhibition rate was calculated using the MTT (3-(4,5-dimethylthiazol-2-yl)02,5-diphenyl-2H tetrazolium bromide) assay. Results: Fifty-one patients (57.3%) were sensitive to 5-FU according to the chemosensitivity test. After a median follow-up of 64 months, there was a significant difference between the 5-year disease-free survival rates of the chemosensitive and chemo-resistant groups. However, there was no significant difference in the overall 5-year survival between the chemo-sensitive and chemo-resistant groups. Conclusion: A positive 5-FU sensitivity test with in vitro histoculture drug response assay (HDRA) was associated with better diseasefree survival. Chemosensitivity may be a prognostic factor for colorectal cancer patients undergoing adjuvant 5-FU/ leucovorin chemotherapy.

Original languageEnglish
Pages (from-to)2679-2682
Number of pages4
JournalAnticancer Research
Volume37
Issue number5
DOIs
Publication statusPublished - 2017 May 1

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Keywords

  • 5-fluorouracil
  • Chemosensitivity
  • Chemotherapy
  • Colorectal cancer
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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