Abstract
Aim: To evaluate whether the results of chemosensitivity testing were associated with prognosis of colorectal cancer patients after adjuvant 5-fluorouracil (FU)/ leucovorin chemotherapy. Patients and Methods: Eighty-nine patients who received 5-FU/leucovorin adjuvant chemotherapy for colorectal cancer were enrolled. Chemosensitivity tests were performed and tumor growth inhibition rate was calculated using the MTT (3-(4,5-dimethylthiazol-2-yl)02,5-diphenyl-2H tetrazolium bromide) assay. Results: Fifty-one patients (57.3%) were sensitive to 5-FU according to the chemosensitivity test. After a median follow-up of 64 months, there was a significant difference between the 5-year disease-free survival rates of the chemosensitive and chemo-resistant groups. However, there was no significant difference in the overall 5-year survival between the chemo-sensitive and chemo-resistant groups. Conclusion: A positive 5-FU sensitivity test with in vitro histoculture drug response assay (HDRA) was associated with better diseasefree survival. Chemosensitivity may be a prognostic factor for colorectal cancer patients undergoing adjuvant 5-FU/ leucovorin chemotherapy.
Original language | English |
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Pages (from-to) | 2679-2682 |
Number of pages | 4 |
Journal | Anticancer research |
Volume | 37 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2017 May |
Keywords
- 5-fluorouracil
- Chemosensitivity
- Chemotherapy
- Colorectal cancer
- Survival
ASJC Scopus subject areas
- Oncology
- Cancer Research