Clinical significance of galectin-7 in epithelial ovarian cancer

Ha Jeong Kim, Hye Kyung Jeon, Jae Kwan Lee, Chang Ohk Sung, In Gu Do, Chel Hun Choi, Tae Joong Kim, Byoung Gie Kim, Duk Soo Bae, Jeong Won Lee

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20 Citations (Scopus)

Abstract

Background: Galectin-7 (GAL-7) has been highlighted as an important marker in many types of cancers by either inhibiting or promoting tumor growth. In this novel study, we assessed the association of GAL-7 with clinicopathological variables and survival outcomes in epithelial ovarian cancer (EOC) and investigated the role of GAL-7 in proliferation of ovarian cancer cell lines. Materials and Methods: The expression of GAL-7 was determined in 63 formalin-fixed, paraffin-embedded EOC tissues using an immunohistochemical method and we compared various associated clinicopathological factors. To evaluate the role of GAL-7 in cell proliferation, we performed proliferation assays with GAL-7 siRNA using ovarian cancer cell lines, including A2780-PAR cells. Results: Immunohistochemical analysis revealed that GAL-7 expression was primarily detected in nuclei and occasionally in the nucleus and cytoplasm. High GAL-7 expression was associated with greater age (p=0.016), high mortality (p=0.025), and poor overall survival outcome (p=0.029). In addition, the residual tumor volume was larger in the high-expression group compared to the low-expression group, although the difference was not statistically significant (p=0.059). Down-regulation of GAL-7 using siRNA resulted in the inhibition of cell proliferation of A2780-PAR cells. Conclusion: We observed that high GAL-7 might be associated with poor survival outcome in patients with EOC, and may be functionally involved in cell proliferation.

Original languageEnglish
Pages (from-to)1555-1562
Number of pages8
JournalAnticancer research
Volume33
Issue number4
Publication statusPublished - 2013 Apr

Keywords

  • Galectin-7
  • Ovarian cancer
  • Prognosis
  • SiRNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kim, H. J., Jeon, H. K., Lee, J. K., Sung, C. O., Do, I. G., Choi, C. H., Kim, T. J., Kim, B. G., Bae, D. S., & Lee, J. W. (2013). Clinical significance of galectin-7 in epithelial ovarian cancer. Anticancer research, 33(4), 1555-1562.