Clinical significance of pancreatic intraepithelial neoplasia in resectable pancreatic cancer on survivals

Da Young Yu, Young Dong Yu, Wan Bae Kim, Hyung Joon Han, Sae Byul Choi, Dong Sik Kim, Sang Yong Choi, Joo Young Kim, Hyeyoon Chang, Baek Hui Kim

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Purpose: Noninvasive precursor lesions for pancreatic adenocarcinoma include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. PanIN is often found synchronously adjacent to resected pancreatic ductal adenocarcinoma (PDAC) tumors. However, its prognostic significance on outcome after PDAC resection is unknown. The purpose of the current study was to determine if the presence of PanIN has a prognostic or predictive effect on survival after resection for PDAC with curative intent. Methods: We retrospectively reviewed the clinicopathologic data of patients who underwent pancreatectomy for PDAC from January 2002 to January 2013. Intraductal papillary mucinous lesions and mucinous cystic neoplasms were excluded. All available postoperative imaging and clinical follow-up data were reviewed. Results: There were 95 patients who underwent pancreatectomy. Tumors were most commonly located in the pancreas head and as such pancreaticoduodenectomy was the most commonly performed operation. The median tumor size was 3.2 cm. An absence of PanIN lesions was identified in 39 patients (41%). Of the patients with PanIN lesions, high-grade PanIN (grade 3) was the most common type (64.3%) followed by grade 2 (28.6%). There was no significant difference in overall survival or disease-free survival between the non-PanIN and PanIN groups. Conclusion: The presence or absence of PanIN lesions did not affect survival in patients undergoing resection for pancreatic cancer. However, patients with high-grade PanINs tended to have better overall survival. Larger studies with longer follow up are needed to accurately determine its clinical significance.

    Original languageEnglish
    Pages (from-to)247-253
    Number of pages7
    JournalAnnals of Surgical Treatment and Research
    Volume94
    Issue number5
    DOIs
    Publication statusPublished - 2018 May

    Keywords

    • Intraepithelial neoplasm
    • Pancreatic neoplasms
    • Survival

    ASJC Scopus subject areas

    • Surgery

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