Clinical significance of serum vascular endothelial growth factor in young male asthma patients

Hea Yon Lee, Kyung Hoon Min, Sang Min Lee, Ji Eun Lee, Chin Kook Rhee

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and those with exacerbation of acute asthma. All subjects were young males. Methods: We measured VEGF levels in each patient group, and examined any serial changes in those with acute exacerbation. Results: VEGF levels were significantly higher in stable asthmatic patients and even more so in acute asthmatic patients, compared to healthy controls. However, there was no correlation between VEGF levels and forced expiratory volume in 1 second in patients with stable asthma. In addition, there were no correlations between VEGF levels and asthma control test scores. In patients with acute exacerbation, VEGF levels significantly increased during the acute period; their levels decreased gradually at 7 and 14 days after treatment. Conclusions: Compared to normal control patients, the serum levels of VEGF were elevated in stable asthma patients and even more elevated in patients with acute exacerbation. However, the role of VEGF as a biomarker in stable asthma is limited. In patients with acute exacerbation, VEGF levels were associated with clinical improvements.

    Original languageEnglish
    Pages (from-to)295-301
    Number of pages7
    JournalKorean Journal of Internal Medicine
    Volume32
    Issue number2
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Asthma
    • Lung function
    • Serum
    • Vascular endothelial growth factor A

    ASJC Scopus subject areas

    • Internal Medicine

    Fingerprint

    Dive into the research topics of 'Clinical significance of serum vascular endothelial growth factor in young male asthma patients'. Together they form a unique fingerprint.

    Cite this