Clinical Significance of Subclassification of Papillary Renal Cell Carcinoma: Comparison of Clinicopathologic Parameters and Oncologic Outcomes Between Papillary Histologic Subtypes 1 and 2 Using the Korean Renal Cell Carcinoma Database

Korean Renal Cell Carcinoma Study Group

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5 Citations (Scopus)

Abstract

The aim of the present study was to investigate the clinical significance of the subclassification of papillary renal cell carcinoma (pRCC) in a multi-institutional study of 274 Korean patients with pRCC. Type 2 pRCC displayed more aggressive clinicopathologic characteristics; however, no significant differences in prognosis were found between types 1 and 2 pRCC. Among patients with pRCC, the pathologic T stage was the only prognosticator. Introduction The aims of the present study were to compare the clinicopathologic characteristics between type 1 and type 2 papillary renal cell carcinoma (pRCC) and to evaluate the effect of the subclassification of pRCC on the oncologic outcomes after surgery. Materials and Methods The records of 274 patients with pRCC in the Korean renal cell carcinoma (KORCC) database were included for evaluation. Of the 274 patients, 118 had type 1 pRCC and 156 had type 2 pRCC. The patient characteristics, including clinicopathologic parameters, were investigated, and the oncologic outcomes were evaluated. Results The mean patient age was significantly older in the type 2 pRCC group. Compared with type 1 pRCC tumors, type 2 pRCC tumors were more often localized to the renal hilum (P = .030). Patients with type 2 pRCC had a greater incidence of Fuhrman grade 3 and 4 tumors than those with type 1 pRCC (78.8% vs. 22.8; P < .001). Tumor necrosis and capsular invasion were more frequently found in type 2 pRCC (P = .008 and P = .007, respectively). At a mean follow-up period of 38.0 months (interquartile range, 11.8-57.3 months), the subclassification of pRCC did not influence the prognosis of patients with pRCC. Conclusion From the information available in the KORCC database, we identified significant differences in clinicopathologic variables, including age, Fuhrman grade, tumor location, tumor necrosis, and capsular invasion between type 1 and 2 pRCC. Although type 2 pRCC had more aggressive clinicopathologic characteristics, subclassification of pRCC did not affect the oncologic outcomes.

Original languageEnglish
Pages (from-to)e181-e186
JournalClinical Genitourinary Cancer
Volume15
Issue number2
DOIs
Publication statusPublished - 2017 Apr 1

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Renal Cell Carcinoma
Databases
Neoplasms
Necrosis

Keywords

  • KORCC database
  • Nephrectomy
  • pRCC
  • Prognosis
  • T stage

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

@article{093614dd916f44659bdc38e9391e1152,
title = "Clinical Significance of Subclassification of Papillary Renal Cell Carcinoma: Comparison of Clinicopathologic Parameters and Oncologic Outcomes Between Papillary Histologic Subtypes 1 and 2 Using the Korean Renal Cell Carcinoma Database",
abstract = "The aim of the present study was to investigate the clinical significance of the subclassification of papillary renal cell carcinoma (pRCC) in a multi-institutional study of 274 Korean patients with pRCC. Type 2 pRCC displayed more aggressive clinicopathologic characteristics; however, no significant differences in prognosis were found between types 1 and 2 pRCC. Among patients with pRCC, the pathologic T stage was the only prognosticator. Introduction The aims of the present study were to compare the clinicopathologic characteristics between type 1 and type 2 papillary renal cell carcinoma (pRCC) and to evaluate the effect of the subclassification of pRCC on the oncologic outcomes after surgery. Materials and Methods The records of 274 patients with pRCC in the Korean renal cell carcinoma (KORCC) database were included for evaluation. Of the 274 patients, 118 had type 1 pRCC and 156 had type 2 pRCC. The patient characteristics, including clinicopathologic parameters, were investigated, and the oncologic outcomes were evaluated. Results The mean patient age was significantly older in the type 2 pRCC group. Compared with type 1 pRCC tumors, type 2 pRCC tumors were more often localized to the renal hilum (P = .030). Patients with type 2 pRCC had a greater incidence of Fuhrman grade 3 and 4 tumors than those with type 1 pRCC (78.8{\%} vs. 22.8; P < .001). Tumor necrosis and capsular invasion were more frequently found in type 2 pRCC (P = .008 and P = .007, respectively). At a mean follow-up period of 38.0 months (interquartile range, 11.8-57.3 months), the subclassification of pRCC did not influence the prognosis of patients with pRCC. Conclusion From the information available in the KORCC database, we identified significant differences in clinicopathologic variables, including age, Fuhrman grade, tumor location, tumor necrosis, and capsular invasion between type 1 and 2 pRCC. Although type 2 pRCC had more aggressive clinicopathologic characteristics, subclassification of pRCC did not affect the oncologic outcomes.",
keywords = "KORCC database, Nephrectomy, pRCC, Prognosis, T stage",
author = "{Korean Renal Cell Carcinoma Study Group} and Ha, {Yun Sok} and Chung, {Jae Wook} and Choi, {Seock Hwan} and Lee, {Jun Nyung} and Kim, {Hyun Tae} and Kim, {Tae Hwan} and Chung, {Sung Kwang} and Byun, {Seok Soo} and Hwang, {Eu Chang} and Kang, {Seok Ho} and Hong, {Sung Hoo} and Jinsoo Chung and Cheol Kwak and Kim, {Yong June} and Kwon, {Tae Gyun}",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.clgc.2016.07.020",
language = "English",
volume = "15",
pages = "e181--e186",
journal = "Clinical Genitourinary Cancer",
issn = "1558-7673",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Clinical Significance of Subclassification of Papillary Renal Cell Carcinoma

T2 - Comparison of Clinicopathologic Parameters and Oncologic Outcomes Between Papillary Histologic Subtypes 1 and 2 Using the Korean Renal Cell Carcinoma Database

AU - Korean Renal Cell Carcinoma Study Group

AU - Ha, Yun Sok

AU - Chung, Jae Wook

AU - Choi, Seock Hwan

AU - Lee, Jun Nyung

AU - Kim, Hyun Tae

AU - Kim, Tae Hwan

AU - Chung, Sung Kwang

AU - Byun, Seok Soo

AU - Hwang, Eu Chang

AU - Kang, Seok Ho

AU - Hong, Sung Hoo

AU - Chung, Jinsoo

AU - Kwak, Cheol

AU - Kim, Yong June

AU - Kwon, Tae Gyun

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The aim of the present study was to investigate the clinical significance of the subclassification of papillary renal cell carcinoma (pRCC) in a multi-institutional study of 274 Korean patients with pRCC. Type 2 pRCC displayed more aggressive clinicopathologic characteristics; however, no significant differences in prognosis were found between types 1 and 2 pRCC. Among patients with pRCC, the pathologic T stage was the only prognosticator. Introduction The aims of the present study were to compare the clinicopathologic characteristics between type 1 and type 2 papillary renal cell carcinoma (pRCC) and to evaluate the effect of the subclassification of pRCC on the oncologic outcomes after surgery. Materials and Methods The records of 274 patients with pRCC in the Korean renal cell carcinoma (KORCC) database were included for evaluation. Of the 274 patients, 118 had type 1 pRCC and 156 had type 2 pRCC. The patient characteristics, including clinicopathologic parameters, were investigated, and the oncologic outcomes were evaluated. Results The mean patient age was significantly older in the type 2 pRCC group. Compared with type 1 pRCC tumors, type 2 pRCC tumors were more often localized to the renal hilum (P = .030). Patients with type 2 pRCC had a greater incidence of Fuhrman grade 3 and 4 tumors than those with type 1 pRCC (78.8% vs. 22.8; P < .001). Tumor necrosis and capsular invasion were more frequently found in type 2 pRCC (P = .008 and P = .007, respectively). At a mean follow-up period of 38.0 months (interquartile range, 11.8-57.3 months), the subclassification of pRCC did not influence the prognosis of patients with pRCC. Conclusion From the information available in the KORCC database, we identified significant differences in clinicopathologic variables, including age, Fuhrman grade, tumor location, tumor necrosis, and capsular invasion between type 1 and 2 pRCC. Although type 2 pRCC had more aggressive clinicopathologic characteristics, subclassification of pRCC did not affect the oncologic outcomes.

AB - The aim of the present study was to investigate the clinical significance of the subclassification of papillary renal cell carcinoma (pRCC) in a multi-institutional study of 274 Korean patients with pRCC. Type 2 pRCC displayed more aggressive clinicopathologic characteristics; however, no significant differences in prognosis were found between types 1 and 2 pRCC. Among patients with pRCC, the pathologic T stage was the only prognosticator. Introduction The aims of the present study were to compare the clinicopathologic characteristics between type 1 and type 2 papillary renal cell carcinoma (pRCC) and to evaluate the effect of the subclassification of pRCC on the oncologic outcomes after surgery. Materials and Methods The records of 274 patients with pRCC in the Korean renal cell carcinoma (KORCC) database were included for evaluation. Of the 274 patients, 118 had type 1 pRCC and 156 had type 2 pRCC. The patient characteristics, including clinicopathologic parameters, were investigated, and the oncologic outcomes were evaluated. Results The mean patient age was significantly older in the type 2 pRCC group. Compared with type 1 pRCC tumors, type 2 pRCC tumors were more often localized to the renal hilum (P = .030). Patients with type 2 pRCC had a greater incidence of Fuhrman grade 3 and 4 tumors than those with type 1 pRCC (78.8% vs. 22.8; P < .001). Tumor necrosis and capsular invasion were more frequently found in type 2 pRCC (P = .008 and P = .007, respectively). At a mean follow-up period of 38.0 months (interquartile range, 11.8-57.3 months), the subclassification of pRCC did not influence the prognosis of patients with pRCC. Conclusion From the information available in the KORCC database, we identified significant differences in clinicopathologic variables, including age, Fuhrman grade, tumor location, tumor necrosis, and capsular invasion between type 1 and 2 pRCC. Although type 2 pRCC had more aggressive clinicopathologic characteristics, subclassification of pRCC did not affect the oncologic outcomes.

KW - KORCC database

KW - Nephrectomy

KW - pRCC

KW - Prognosis

KW - T stage

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U2 - 10.1016/j.clgc.2016.07.020

DO - 10.1016/j.clgc.2016.07.020

M3 - Article

C2 - 27595560

AN - SCOPUS:84994137658

VL - 15

SP - e181-e186

JO - Clinical Genitourinary Cancer

JF - Clinical Genitourinary Cancer

SN - 1558-7673

IS - 2

ER -