Clinical significance of the pattern of lymph node metastasis depending on the location of gastric cancer

Ki Bin Han, You-Jin Jang, Jong Han Kim, Sungsoo Park, Seong-Heum Park, Seung Joo Kim, Young Jae Mok, Chong Suk Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: When performing a laparoscopic assisted gastrectomy, a function-preserving gastrectomy is performed depending on the location of the primary gastric cancer. This study examined the incidence of lymph node metastasis by the lymph node station number by tumor location to determine the optimal extent of the lymph node dissection. Materials and Methods: The subjects consisted of 1,510 patients diagnosed with gastric cancer who underwent a gastrectomy between 1996 and 2005. The patients were divided into three groups: upper, middle and lower third, depending on the location of the primary tumor. The lymph node metastasis patterns were analyzed in the total and early gastric cancer patients. Results: In all patients, lymph node station numbers 1, 2, 3, 7, 10 and 11 metastases were dominant in the cancer originating in the upper third, whereas station numbers 4, 5, 6 and 8 were dominant in the lower third. In early gastric cancer patients, the station number of lymph nodes with a metastasis did not show a significant difference in stage pT1a disease. On the other hand, a metastasis in lymph node station number 6 was dominant in stage pT1b disease that originated in the lower third of the stomach. Conclusions: When performing a laparoscopic-assisted gastrectomy for early gastric cancer, a limited lymphadenectomy is considered adequate during a function-preserving gastrectomy in mucosal (T1a) cancer. On the other hand, for submucosal (T1b) cancer, a number 6 node dissection should be performed when performing a pylorus preserving gastrectomy.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalJournal of Gastric Cancer
Volume11
Issue number2
DOIs
Publication statusPublished - 2011 Dec 1

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Gastrectomy
Stomach Neoplasms
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Lymph Node Excision
Pylorus
Dissection
Stomach
Cohort Studies

Keywords

  • Lymphatic metastasis
  • Stomach neoplasms
  • Tumor location

ASJC Scopus subject areas

  • Gastroenterology
  • Oncology
  • Cancer Research

Cite this

Clinical significance of the pattern of lymph node metastasis depending on the location of gastric cancer. / Han, Ki Bin; Jang, You-Jin; Kim, Jong Han; Park, Sungsoo; Park, Seong-Heum; Kim, Seung Joo; Mok, Young Jae; Kim, Chong Suk.

In: Journal of Gastric Cancer, Vol. 11, No. 2, 01.12.2011, p. 86-93.

Research output: Contribution to journalArticle

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abstract = "Purpose: When performing a laparoscopic assisted gastrectomy, a function-preserving gastrectomy is performed depending on the location of the primary gastric cancer. This study examined the incidence of lymph node metastasis by the lymph node station number by tumor location to determine the optimal extent of the lymph node dissection. Materials and Methods: The subjects consisted of 1,510 patients diagnosed with gastric cancer who underwent a gastrectomy between 1996 and 2005. The patients were divided into three groups: upper, middle and lower third, depending on the location of the primary tumor. The lymph node metastasis patterns were analyzed in the total and early gastric cancer patients. Results: In all patients, lymph node station numbers 1, 2, 3, 7, 10 and 11 metastases were dominant in the cancer originating in the upper third, whereas station numbers 4, 5, 6 and 8 were dominant in the lower third. In early gastric cancer patients, the station number of lymph nodes with a metastasis did not show a significant difference in stage pT1a disease. On the other hand, a metastasis in lymph node station number 6 was dominant in stage pT1b disease that originated in the lower third of the stomach. Conclusions: When performing a laparoscopic-assisted gastrectomy for early gastric cancer, a limited lymphadenectomy is considered adequate during a function-preserving gastrectomy in mucosal (T1a) cancer. On the other hand, for submucosal (T1b) cancer, a number 6 node dissection should be performed when performing a pylorus preserving gastrectomy.",
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