Clinical significance of variceal hemorrhage in recent years in patients with liver cirrhosis and esophageal varices

Kyu Park Dong, Soon-Ho Um, Won Lee Jae, Bok Lee Jung, Sun Kim Young, Hee Park Chul, Tae Jin Yoon, Hoon-Jai Chun, Hong Sik Lee, Sang Woo Lee, Hyun Choi Jai, Chang Duck Kim, Sang Ryu Ho, Hai Hyun Jin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background and Aims: Recent progress in the treatment of variceal bleeding might have reduced the impact of variceal bleeding on survival in patients with esophageal varices. We conducted a retrospective cohort study in an attempt to re-evaluate the clinical significance of variceal bleeding. Methods. A cohort of 304 patients with liver cirrhosis and esophageal varices, who had no previous history of variceal bleeding and no prophylactic therapy, was studied. Results. During a median follow-up period of 32 months, 55 patients (18%) bled from varices and 111 (37%) died. Variceal hemorrhages accounted for 15% of total deaths. The mortality of first variceal bleeding was 25% in the whole group, but was remarkably different depending on liver function at the time of bleeding (0% in grade Child A vs 55% in grade C; P < 0.05). Among the survivors of first bleeding, 30% experienced rebleeding. Form of varix, red color sign and heavy drinking were the independent risk factors for first variceal bleeding. Multivariate analysis revealed that variceal bleeding still had a significant (P < 0.001) impact on death in the whole cohort, when other independent prognostic factors such as age, ascites, encephalopathy, platelet count, serum albumin level and hepatocellular carcinoma were adjusted. Furthermore, in subgroup analyses, variceal bleeding was more strongly (P < 0.001) linked to death in patients with alcoholic cirrhosis than in those with non-alcoholic cirrhosis, and showed a significant association with survival only for the patients in Child grade B. Conclusions: Variceal bleeding has various prognostic impacts depending on the etiology of cirrhosis or on the degree of liver dysfunction, and this needs to be taken into account in the prophylaxis against first variceal bleeding.

Original languageEnglish
Pages (from-to)1042-1051
Number of pages10
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume19
Issue number9
DOIs
Publication statusPublished - 2004 Jan 1

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Esophageal and Gastric Varices
Liver Cirrhosis
Hemorrhage
Varicose Veins
Fibrosis
Alcoholic Liver Cirrhosis
Bleeding Time
Survival
Brain Diseases
Platelet Count
Ascites
Serum Albumin
Drinking
Survivors
Liver Diseases
Hepatocellular Carcinoma
Cohort Studies
Multivariate Analysis
Retrospective Studies
Color

Keywords

  • Esophageal varix
  • Hemorrhage
  • Liver cirrhosis
  • Survival

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Clinical significance of variceal hemorrhage in recent years in patients with liver cirrhosis and esophageal varices. / Dong, Kyu Park; Um, Soon-Ho; Jae, Won Lee; Jung, Bok Lee; Young, Sun Kim; Chul, Hee Park; Yoon, Tae Jin; Chun, Hoon-Jai; Lee, Hong Sik; Lee, Sang Woo; Jai, Hyun Choi; Kim, Chang Duck; Ho, Sang Ryu; Jin, Hai Hyun.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 19, No. 9, 01.01.2004, p. 1042-1051.

Research output: Contribution to journalArticle

Dong, Kyu Park ; Um, Soon-Ho ; Jae, Won Lee ; Jung, Bok Lee ; Young, Sun Kim ; Chul, Hee Park ; Yoon, Tae Jin ; Chun, Hoon-Jai ; Lee, Hong Sik ; Lee, Sang Woo ; Jai, Hyun Choi ; Kim, Chang Duck ; Ho, Sang Ryu ; Jin, Hai Hyun. / Clinical significance of variceal hemorrhage in recent years in patients with liver cirrhosis and esophageal varices. In: Journal of Gastroenterology and Hepatology (Australia). 2004 ; Vol. 19, No. 9. pp. 1042-1051.
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AU - Young, Sun Kim

AU - Chul, Hee Park

AU - Yoon, Tae Jin

AU - Chun, Hoon-Jai

AU - Lee, Hong Sik

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