Clinical significance of ventilator-associated event

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose A novel surveillance algorithm of ventilator-associated event (VAE) was introduced to overcome the subjectivity of conventional ventilator-associated pneumonia. We investigated the risk factors and prognostic values of VAE. Methods We conducted a retrospective study of 869 patients treated with mechanical ventilation for greater than or equal to 2 calendar days from January 2013 to June 2014. We compared the episodes of mechanical ventilation with or without VAE and analyzed risk factors and clinical outcomes of VAE. Results Among 1031 episodes of mechanical ventilation, 92 episodes were complicated with VAE. VAE occurred more frequently when the initial causes of mechanical ventilation were trauma (odds ratio [OR], 2.7; 95% confidence interval [CI], 1.1-6.3) and pulmonary edema (OR, 2.4; 95% CI, 1.2-4.7). VAE was significantly associated with prolonged mechanical ventilation (5 vs 12 days; P < .001), reduced rate of successful extubation (50.1% vs 17.5%; P < .001), and increased 30-day mortality (35.6% vs 74.2%; P < .001). VAE was a significant risk factor of 30-day mortality on multivariate regression analysis (OR, 3.6; 95% CI, 2.0-6.6; P < .001). Conclusions Patients treated with mechanical ventilation due to pulmonary edema or trauma had increased risk of VAE, with its development indicative of adverse clinical outcomes.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalJournal of Critical Care
Volume35
DOIs
Publication statusPublished - 2016 Oct 1

Fingerprint

Mechanical Ventilators
Artificial Respiration
Odds Ratio
Pulmonary Edema
Confidence Intervals
Ventilator-Associated Pneumonia
Mortality
Wounds and Injuries
Multivariate Analysis
Retrospective Studies
Regression Analysis

Keywords

  • Pulmonary edema
  • Trauma
  • Ventilator-associated event
  • Ventilator-associated pneumonia

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Clinical significance of ventilator-associated event. / Sim, Jae Kyeom; Oh, Jee Youn; Min, Kyung-Hoon; Hur, Gyu Young; Lee, Seung Heon; Lee, Sung Yong; Kim, Je Hyeong; Shin, Chol; Shim, Jae Jeong; Kang, Kyung Ho.

In: Journal of Critical Care, Vol. 35, 01.10.2016, p. 19-23.

Research output: Contribution to journalArticle

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abstract = "Purpose A novel surveillance algorithm of ventilator-associated event (VAE) was introduced to overcome the subjectivity of conventional ventilator-associated pneumonia. We investigated the risk factors and prognostic values of VAE. Methods We conducted a retrospective study of 869 patients treated with mechanical ventilation for greater than or equal to 2 calendar days from January 2013 to June 2014. We compared the episodes of mechanical ventilation with or without VAE and analyzed risk factors and clinical outcomes of VAE. Results Among 1031 episodes of mechanical ventilation, 92 episodes were complicated with VAE. VAE occurred more frequently when the initial causes of mechanical ventilation were trauma (odds ratio [OR], 2.7; 95{\%} confidence interval [CI], 1.1-6.3) and pulmonary edema (OR, 2.4; 95{\%} CI, 1.2-4.7). VAE was significantly associated with prolonged mechanical ventilation (5 vs 12 days; P < .001), reduced rate of successful extubation (50.1{\%} vs 17.5{\%}; P < .001), and increased 30-day mortality (35.6{\%} vs 74.2{\%}; P < .001). VAE was a significant risk factor of 30-day mortality on multivariate regression analysis (OR, 3.6; 95{\%} CI, 2.0-6.6; P < .001). Conclusions Patients treated with mechanical ventilation due to pulmonary edema or trauma had increased risk of VAE, with its development indicative of adverse clinical outcomes.",
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author = "Sim, {Jae Kyeom} and Oh, {Jee Youn} and Kyung-Hoon Min and Hur, {Gyu Young} and Lee, {Seung Heon} and Lee, {Sung Yong} and Kim, {Je Hyeong} and Chol Shin and Shim, {Jae Jeong} and Kang, {Kyung Ho}",
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AU - Sim, Jae Kyeom

AU - Oh, Jee Youn

AU - Min, Kyung-Hoon

AU - Hur, Gyu Young

AU - Lee, Seung Heon

AU - Lee, Sung Yong

AU - Kim, Je Hyeong

AU - Shin, Chol

AU - Shim, Jae Jeong

AU - Kang, Kyung Ho

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N2 - Purpose A novel surveillance algorithm of ventilator-associated event (VAE) was introduced to overcome the subjectivity of conventional ventilator-associated pneumonia. We investigated the risk factors and prognostic values of VAE. Methods We conducted a retrospective study of 869 patients treated with mechanical ventilation for greater than or equal to 2 calendar days from January 2013 to June 2014. We compared the episodes of mechanical ventilation with or without VAE and analyzed risk factors and clinical outcomes of VAE. Results Among 1031 episodes of mechanical ventilation, 92 episodes were complicated with VAE. VAE occurred more frequently when the initial causes of mechanical ventilation were trauma (odds ratio [OR], 2.7; 95% confidence interval [CI], 1.1-6.3) and pulmonary edema (OR, 2.4; 95% CI, 1.2-4.7). VAE was significantly associated with prolonged mechanical ventilation (5 vs 12 days; P < .001), reduced rate of successful extubation (50.1% vs 17.5%; P < .001), and increased 30-day mortality (35.6% vs 74.2%; P < .001). VAE was a significant risk factor of 30-day mortality on multivariate regression analysis (OR, 3.6; 95% CI, 2.0-6.6; P < .001). Conclusions Patients treated with mechanical ventilation due to pulmonary edema or trauma had increased risk of VAE, with its development indicative of adverse clinical outcomes.

AB - Purpose A novel surveillance algorithm of ventilator-associated event (VAE) was introduced to overcome the subjectivity of conventional ventilator-associated pneumonia. We investigated the risk factors and prognostic values of VAE. Methods We conducted a retrospective study of 869 patients treated with mechanical ventilation for greater than or equal to 2 calendar days from January 2013 to June 2014. We compared the episodes of mechanical ventilation with or without VAE and analyzed risk factors and clinical outcomes of VAE. Results Among 1031 episodes of mechanical ventilation, 92 episodes were complicated with VAE. VAE occurred more frequently when the initial causes of mechanical ventilation were trauma (odds ratio [OR], 2.7; 95% confidence interval [CI], 1.1-6.3) and pulmonary edema (OR, 2.4; 95% CI, 1.2-4.7). VAE was significantly associated with prolonged mechanical ventilation (5 vs 12 days; P < .001), reduced rate of successful extubation (50.1% vs 17.5%; P < .001), and increased 30-day mortality (35.6% vs 74.2%; P < .001). VAE was a significant risk factor of 30-day mortality on multivariate regression analysis (OR, 3.6; 95% CI, 2.0-6.6; P < .001). Conclusions Patients treated with mechanical ventilation due to pulmonary edema or trauma had increased risk of VAE, with its development indicative of adverse clinical outcomes.

KW - Pulmonary edema

KW - Trauma

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KW - Ventilator-associated pneumonia

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