Clinical study of adrenal incidentaloma in Korea

Young Kim Hee, Sin Gon Kim, Won Lee Kye, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei-Hyun Baik, Seop Choi Dong

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background : This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas. Methods : Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively. Results : Endocrinological investigation revealed 16 pheochromocytomas (20%), nine Cushing's syndromes (11%), eight primary aldosteronism (10%) and 46 non-functioning tumors (58%). Forty-four patients received operations, and biopsies were performed on two patients. Pathologic examination revealed 16 adrenocortical adenomas (20%), five carcinomas (6%), 13 pheochromocytomas (16%), three metastatic cancers (4%), and other tumors (10%). The diameter of the carcinomas (mean: 10.8 cm, range: 5-19 cm) were significantly larger than the diameter of benign adenomas (mean: 2.84 cm, range: 1-6 cm) (p=0.002). According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90%, specificity 58%). Twenty-four patients with non-functioning tumors were followed up for a period of 3 to 72 months. During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome. Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis. Conclusions : These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction. In addition, these tumors should be monitored for changes in mass size and function for a follow up period of approximately 26 months.

Original languageEnglish
Pages (from-to)303-309
Number of pages7
JournalKorean Journal of Internal Medicine
Volume20
Issue number4
Publication statusPublished - 2005 Dec 1

Fingerprint

Korea
Neoplasms
Cushing Syndrome
Pheochromocytoma
Adrenal incidentaloma
Clinical Studies
Adrenocortical Hyperfunction
Adrenocortical Adenoma
Carcinoma
Hyperaldosteronism
Adrenalectomy
Adenoma
Biopsy
Sensitivity and Specificity

Keywords

  • Adrenalectomy
  • Adrenocortical adenoma
  • Carcinoma
  • Hyperfunction

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Clinical study of adrenal incidentaloma in Korea. / Hee, Young Kim; Kim, Sin Gon; Kye, Won Lee; Seo, Ji A; Kim, Nan Hee; Choi, Kyung Mook; Baik, Sei-Hyun; Dong, Seop Choi.

In: Korean Journal of Internal Medicine, Vol. 20, No. 4, 01.12.2005, p. 303-309.

Research output: Contribution to journalArticle

@article{e644c6dd932e49aca1ece88a1041a488,
title = "Clinical study of adrenal incidentaloma in Korea",
abstract = "Background : This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas. Methods : Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively. Results : Endocrinological investigation revealed 16 pheochromocytomas (20{\%}), nine Cushing's syndromes (11{\%}), eight primary aldosteronism (10{\%}) and 46 non-functioning tumors (58{\%}). Forty-four patients received operations, and biopsies were performed on two patients. Pathologic examination revealed 16 adrenocortical adenomas (20{\%}), five carcinomas (6{\%}), 13 pheochromocytomas (16{\%}), three metastatic cancers (4{\%}), and other tumors (10{\%}). The diameter of the carcinomas (mean: 10.8 cm, range: 5-19 cm) were significantly larger than the diameter of benign adenomas (mean: 2.84 cm, range: 1-6 cm) (p=0.002). According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90{\%}, specificity 58{\%}). Twenty-four patients with non-functioning tumors were followed up for a period of 3 to 72 months. During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome. Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis. Conclusions : These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction. In addition, these tumors should be monitored for changes in mass size and function for a follow up period of approximately 26 months.",
keywords = "Adrenalectomy, Adrenocortical adenoma, Carcinoma, Hyperfunction",
author = "Hee, {Young Kim} and Kim, {Sin Gon} and Kye, {Won Lee} and Seo, {Ji A} and Kim, {Nan Hee} and Choi, {Kyung Mook} and Sei-Hyun Baik and Dong, {Seop Choi}",
year = "2005",
month = "12",
day = "1",
language = "English",
volume = "20",
pages = "303--309",
journal = "Korean Journal of Internal Medicine",
issn = "0494-4712",
publisher = "Korean Association of Internal Medicine",
number = "4",

}

TY - JOUR

T1 - Clinical study of adrenal incidentaloma in Korea

AU - Hee, Young Kim

AU - Kim, Sin Gon

AU - Kye, Won Lee

AU - Seo, Ji A

AU - Kim, Nan Hee

AU - Choi, Kyung Mook

AU - Baik, Sei-Hyun

AU - Dong, Seop Choi

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Background : This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas. Methods : Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively. Results : Endocrinological investigation revealed 16 pheochromocytomas (20%), nine Cushing's syndromes (11%), eight primary aldosteronism (10%) and 46 non-functioning tumors (58%). Forty-four patients received operations, and biopsies were performed on two patients. Pathologic examination revealed 16 adrenocortical adenomas (20%), five carcinomas (6%), 13 pheochromocytomas (16%), three metastatic cancers (4%), and other tumors (10%). The diameter of the carcinomas (mean: 10.8 cm, range: 5-19 cm) were significantly larger than the diameter of benign adenomas (mean: 2.84 cm, range: 1-6 cm) (p=0.002). According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90%, specificity 58%). Twenty-four patients with non-functioning tumors were followed up for a period of 3 to 72 months. During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome. Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis. Conclusions : These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction. In addition, these tumors should be monitored for changes in mass size and function for a follow up period of approximately 26 months.

AB - Background : This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas. Methods : Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively. Results : Endocrinological investigation revealed 16 pheochromocytomas (20%), nine Cushing's syndromes (11%), eight primary aldosteronism (10%) and 46 non-functioning tumors (58%). Forty-four patients received operations, and biopsies were performed on two patients. Pathologic examination revealed 16 adrenocortical adenomas (20%), five carcinomas (6%), 13 pheochromocytomas (16%), three metastatic cancers (4%), and other tumors (10%). The diameter of the carcinomas (mean: 10.8 cm, range: 5-19 cm) were significantly larger than the diameter of benign adenomas (mean: 2.84 cm, range: 1-6 cm) (p=0.002). According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90%, specificity 58%). Twenty-four patients with non-functioning tumors were followed up for a period of 3 to 72 months. During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome. Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis. Conclusions : These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction. In addition, these tumors should be monitored for changes in mass size and function for a follow up period of approximately 26 months.

KW - Adrenalectomy

KW - Adrenocortical adenoma

KW - Carcinoma

KW - Hyperfunction

UR - http://www.scopus.com/inward/record.url?scp=33645803386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645803386&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 303

EP - 309

JO - Korean Journal of Internal Medicine

JF - Korean Journal of Internal Medicine

SN - 0494-4712

IS - 4

ER -