Abstract
Background : This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas. Methods : Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively. Results : Endocrinological investigation revealed 16 pheochromocytomas (20%), nine Cushing's syndromes (11%), eight primary aldosteronism (10%) and 46 non-functioning tumors (58%). Forty-four patients received operations, and biopsies were performed on two patients. Pathologic examination revealed 16 adrenocortical adenomas (20%), five carcinomas (6%), 13 pheochromocytomas (16%), three metastatic cancers (4%), and other tumors (10%). The diameter of the carcinomas (mean: 10.8 cm, range: 5-19 cm) were significantly larger than the diameter of benign adenomas (mean: 2.84 cm, range: 1-6 cm) (p=0.002). According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90%, specificity 58%). Twenty-four patients with non-functioning tumors were followed up for a period of 3 to 72 months. During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome. Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis. Conclusions : These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction. In addition, these tumors should be monitored for changes in mass size and function for a follow up period of approximately 26 months.
| Original language | English |
|---|---|
| Pages (from-to) | 303-309 |
| Number of pages | 7 |
| Journal | Korean Journal of Internal Medicine |
| Volume | 20 |
| Issue number | 4 |
| Publication status | Published - 2005 Dec 1 |
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Keywords
- Adrenalectomy
- Adrenocortical adenoma
- Carcinoma
- Hyperfunction
ASJC Scopus subject areas
- Internal Medicine
Cite this
Clinical study of adrenal incidentaloma in Korea. / Hee, Young Kim; Kim, Sin Gon; Kye, Won Lee; Seo, Ji A; Kim, Nan Hee; Choi, Kyung Mook; Baik, Sei-Hyun; Dong, Seop Choi.
In: Korean Journal of Internal Medicine, Vol. 20, No. 4, 01.12.2005, p. 303-309.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinical study of adrenal incidentaloma in Korea
AU - Hee, Young Kim
AU - Kim, Sin Gon
AU - Kye, Won Lee
AU - Seo, Ji A
AU - Kim, Nan Hee
AU - Choi, Kyung Mook
AU - Baik, Sei-Hyun
AU - Dong, Seop Choi
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Background : This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas. Methods : Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively. Results : Endocrinological investigation revealed 16 pheochromocytomas (20%), nine Cushing's syndromes (11%), eight primary aldosteronism (10%) and 46 non-functioning tumors (58%). Forty-four patients received operations, and biopsies were performed on two patients. Pathologic examination revealed 16 adrenocortical adenomas (20%), five carcinomas (6%), 13 pheochromocytomas (16%), three metastatic cancers (4%), and other tumors (10%). The diameter of the carcinomas (mean: 10.8 cm, range: 5-19 cm) were significantly larger than the diameter of benign adenomas (mean: 2.84 cm, range: 1-6 cm) (p=0.002). According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90%, specificity 58%). Twenty-four patients with non-functioning tumors were followed up for a period of 3 to 72 months. During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome. Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis. Conclusions : These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction. In addition, these tumors should be monitored for changes in mass size and function for a follow up period of approximately 26 months.
AB - Background : This study was designed to evaluate the clinical, endocrinological and histological characteristics of adrenal incidentalomas. Methods : Eighty patients (41, males; 38, females; age range 17-80 years) who were diagnosed with adrenal incidentaloma at Korea University Hospital from 1992 to 2003 were studied retrospectively. Results : Endocrinological investigation revealed 16 pheochromocytomas (20%), nine Cushing's syndromes (11%), eight primary aldosteronism (10%) and 46 non-functioning tumors (58%). Forty-four patients received operations, and biopsies were performed on two patients. Pathologic examination revealed 16 adrenocortical adenomas (20%), five carcinomas (6%), 13 pheochromocytomas (16%), three metastatic cancers (4%), and other tumors (10%). The diameter of the carcinomas (mean: 10.8 cm, range: 5-19 cm) were significantly larger than the diameter of benign adenomas (mean: 2.84 cm, range: 1-6 cm) (p=0.002). According to the receiver operating charactenstic (ROC) curve analysis, the cut-off value of tumor size for discriminate malignant tumor was 4.75 cm (sensitivity 90%, specificity 58%). Twenty-four patients with non-functioning tumors were followed up for a period of 3 to 72 months. During the follow up period, two patients showed an increase in tumor size of more than 1 cm, and one patient developed Cushing's syndrome. Changes in mass size and function were observed only between 10 and 26 months after the initial diagnosis. Conclusions : These data show that an endocrine evaluation should be performed in all adrenal incidentalomas, and an adrenalectomy is recommended for tumors 5 cm or greater or tumors with adrenocortical hyperfunction. In addition, these tumors should be monitored for changes in mass size and function for a follow up period of approximately 26 months.
KW - Adrenalectomy
KW - Adrenocortical adenoma
KW - Carcinoma
KW - Hyperfunction
UR - http://www.scopus.com/inward/record.url?scp=33645803386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645803386&partnerID=8YFLogxK
M3 - Article
C2 - 16491828
AN - SCOPUS:33645803386
VL - 20
SP - 303
EP - 309
JO - Korean Journal of Internal Medicine
JF - Korean Journal of Internal Medicine
SN - 0494-4712
IS - 4
ER -