Clinical subtypes and prognosis in breast cancer according to parity: a nationwide study in Korean Breast Cancer Society

Sungmin Park, Byung In Moon, Se Jeong Oh, Han Byoel Lee, Min Ki Seong, Seokwon Lee, Kyung Do Byun, Seung Pil Jung, Soo Youn Bae

Research output: Contribution to journalArticle

Abstract

Purpose: We explored the association between parity and the risk of developing a specific subtype of breast cancer. We also assessed the association between parity and prognosis according to subtypes. Methods: A total of 158,189 patients were enrolled in the Korean Breast Cancer Society Registry database between 1996 and 2015 in Korea. The database provided information on sex, age, number of parity, surgical method, stage, histological findings, presence of biologic markers, adjuvant therapy, and date and cause of death. Results: The patients with higher parity showed a higher ratio of triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER2) subtypes. In univariate analysis, women with TNBC who had more than three children had a worse prognosis compared to other groups (HR 1.83; 95% CI 1.34–2.49; P < 0.001). This association was also observed in women younger than 50 years (HR 1.63; 95% CI 1.07–2.48; P = 0.021). In multivariate analysis stratified by subtypes, women who had more than three children were associated with a worse prognosis in TNBC in the total population (HR 1.53; 95% CI 1.11–2.12; P = 0.011). This association was also observed in patients younger than 50 years of age (HR 1.53; 95% CI 1.09–2.61; P = 0.017). Conclusion: Women who had more than three children were more likely to develop hormone receptor-negative (HR−) subtypes. Women who had more than three children were associated with worse prognosis in patients younger than 50 years of age and in patients with TNBC.

Original languageEnglish
JournalBreast Cancer Research and Treatment
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Triple Negative Breast Neoplasms
Parity
Hormones
Breast Neoplasms
Databases
Korea
Registries
Cause of Death
Multivariate Analysis
Biomarkers
Population

Keywords

  • Breast cancer
  • Parity
  • Prognosis
  • Subtype

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Clinical subtypes and prognosis in breast cancer according to parity : a nationwide study in Korean Breast Cancer Society. / Park, Sungmin; Moon, Byung In; Oh, Se Jeong; Lee, Han Byoel; Seong, Min Ki; Lee, Seokwon; Byun, Kyung Do; Jung, Seung Pil; Bae, Soo Youn.

In: Breast Cancer Research and Treatment, 01.01.2018.

Research output: Contribution to journalArticle

Park, Sungmin ; Moon, Byung In ; Oh, Se Jeong ; Lee, Han Byoel ; Seong, Min Ki ; Lee, Seokwon ; Byun, Kyung Do ; Jung, Seung Pil ; Bae, Soo Youn. / Clinical subtypes and prognosis in breast cancer according to parity : a nationwide study in Korean Breast Cancer Society. In: Breast Cancer Research and Treatment. 2018.
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abstract = "Purpose: We explored the association between parity and the risk of developing a specific subtype of breast cancer. We also assessed the association between parity and prognosis according to subtypes. Methods: A total of 158,189 patients were enrolled in the Korean Breast Cancer Society Registry database between 1996 and 2015 in Korea. The database provided information on sex, age, number of parity, surgical method, stage, histological findings, presence of biologic markers, adjuvant therapy, and date and cause of death. Results: The patients with higher parity showed a higher ratio of triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER2) subtypes. In univariate analysis, women with TNBC who had more than three children had a worse prognosis compared to other groups (HR 1.83; 95{\%} CI 1.34–2.49; P < 0.001). This association was also observed in women younger than 50 years (HR 1.63; 95{\%} CI 1.07–2.48; P = 0.021). In multivariate analysis stratified by subtypes, women who had more than three children were associated with a worse prognosis in TNBC in the total population (HR 1.53; 95{\%} CI 1.11–2.12; P = 0.011). This association was also observed in patients younger than 50 years of age (HR 1.53; 95{\%} CI 1.09–2.61; P = 0.017). Conclusion: Women who had more than three children were more likely to develop hormone receptor-negative (HR−) subtypes. Women who had more than three children were associated with worse prognosis in patients younger than 50 years of age and in patients with TNBC.",
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AU - Lee, Han Byoel

AU - Seong, Min Ki

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AU - Byun, Kyung Do

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AU - Bae, Soo Youn

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N2 - Purpose: We explored the association between parity and the risk of developing a specific subtype of breast cancer. We also assessed the association between parity and prognosis according to subtypes. Methods: A total of 158,189 patients were enrolled in the Korean Breast Cancer Society Registry database between 1996 and 2015 in Korea. The database provided information on sex, age, number of parity, surgical method, stage, histological findings, presence of biologic markers, adjuvant therapy, and date and cause of death. Results: The patients with higher parity showed a higher ratio of triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER2) subtypes. In univariate analysis, women with TNBC who had more than three children had a worse prognosis compared to other groups (HR 1.83; 95% CI 1.34–2.49; P < 0.001). This association was also observed in women younger than 50 years (HR 1.63; 95% CI 1.07–2.48; P = 0.021). In multivariate analysis stratified by subtypes, women who had more than three children were associated with a worse prognosis in TNBC in the total population (HR 1.53; 95% CI 1.11–2.12; P = 0.011). This association was also observed in patients younger than 50 years of age (HR 1.53; 95% CI 1.09–2.61; P = 0.017). Conclusion: Women who had more than three children were more likely to develop hormone receptor-negative (HR−) subtypes. Women who had more than three children were associated with worse prognosis in patients younger than 50 years of age and in patients with TNBC.

AB - Purpose: We explored the association between parity and the risk of developing a specific subtype of breast cancer. We also assessed the association between parity and prognosis according to subtypes. Methods: A total of 158,189 patients were enrolled in the Korean Breast Cancer Society Registry database between 1996 and 2015 in Korea. The database provided information on sex, age, number of parity, surgical method, stage, histological findings, presence of biologic markers, adjuvant therapy, and date and cause of death. Results: The patients with higher parity showed a higher ratio of triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER2) subtypes. In univariate analysis, women with TNBC who had more than three children had a worse prognosis compared to other groups (HR 1.83; 95% CI 1.34–2.49; P < 0.001). This association was also observed in women younger than 50 years (HR 1.63; 95% CI 1.07–2.48; P = 0.021). In multivariate analysis stratified by subtypes, women who had more than three children were associated with a worse prognosis in TNBC in the total population (HR 1.53; 95% CI 1.11–2.12; P = 0.011). This association was also observed in patients younger than 50 years of age (HR 1.53; 95% CI 1.09–2.61; P = 0.017). Conclusion: Women who had more than three children were more likely to develop hormone receptor-negative (HR−) subtypes. Women who had more than three children were associated with worse prognosis in patients younger than 50 years of age and in patients with TNBC.

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