Clinical value of serum uric acid in patients with suspected coronary artery disease

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Abstract

Background/Aims: Although increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established. Methods: The study group comprised 687 consecutive patients with suspected CAD who had undergone coronary angiography. CAD was defined as stenosis ≥ 50% of the luminal diameter. CAD severity was expressed as 1-, 2-, or 3-vessel disease. Metabolic syndrome (MS) was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria, and aortofemoral pulse wave velocity (PWV) was obtained by arterial catheterization invasively. Results: In total, 395 patients had CAD. SUA was higher in patients with CAD as compared to those without CAD (5.5 ± 1.0 vs. 5.2 ± 1.0 mg/dL, p = 0.004). In addition, SUA was significantly associated with the severity of CAD (p = 0.002). However, after adjusting for significant confounding factors including age, diabetes, smoking, cholesterol, MS, and PWV, SUA was not an independent risk factor for CAD (p = 0.151). Based on a subgroup analysis, SUA was more closely associated with CAD in women than in men, and in the highest quartile (≥ 6.4 mg/dL) than in the first quartile (< 4.8 mg/dL); however, these results were not significant (p = 0.062, p = 0.075, respectively). In a multivariate regression analysis, the most important determinant of SUA was MS (i.e., insulin resistance syndrome), which is strongly associated with CAD. Conclusions: In patients with suspected CAD, SUA was not an independent risk factor for CAD and may be merely a marker of insulin resistance.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalKorean Journal of Internal Medicine
Volume25
Issue number1
DOIs
Publication statusPublished - 2010 Mar 1

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Uric Acid
Coronary Artery Disease
Serum
Pulse Wave Analysis
Insulin Resistance
Cholesterol
Age Factors
Coronary Angiography
Catheterization
Pathologic Constriction
Multivariate Analysis
Smoking
Regression Analysis

Keywords

  • Coronary artery disease
  • Insulin resistance
  • Uric acid

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Clinical value of serum uric acid in patients with suspected coronary artery disease",
abstract = "Background/Aims: Although increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established. Methods: The study group comprised 687 consecutive patients with suspected CAD who had undergone coronary angiography. CAD was defined as stenosis ≥ 50{\%} of the luminal diameter. CAD severity was expressed as 1-, 2-, or 3-vessel disease. Metabolic syndrome (MS) was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria, and aortofemoral pulse wave velocity (PWV) was obtained by arterial catheterization invasively. Results: In total, 395 patients had CAD. SUA was higher in patients with CAD as compared to those without CAD (5.5 ± 1.0 vs. 5.2 ± 1.0 mg/dL, p = 0.004). In addition, SUA was significantly associated with the severity of CAD (p = 0.002). However, after adjusting for significant confounding factors including age, diabetes, smoking, cholesterol, MS, and PWV, SUA was not an independent risk factor for CAD (p = 0.151). Based on a subgroup analysis, SUA was more closely associated with CAD in women than in men, and in the highest quartile (≥ 6.4 mg/dL) than in the first quartile (< 4.8 mg/dL); however, these results were not significant (p = 0.062, p = 0.075, respectively). In a multivariate regression analysis, the most important determinant of SUA was MS (i.e., insulin resistance syndrome), which is strongly associated with CAD. Conclusions: In patients with suspected CAD, SUA was not an independent risk factor for CAD and may be merely a marker of insulin resistance.",
keywords = "Coronary artery disease, Insulin resistance, Uric acid",
author = "Lim, {Hong Euy} and Kim, {Seong Hwan} and Kim, {Eung Ju} and Kim, {Jin Won} and Seung-Woon Rha and Seo, {Hong G.} and Park, {Chang Gyu}",
year = "2010",
month = "3",
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doi = "10.3904/kjim.2010.25.1.21",
language = "English",
volume = "25",
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issn = "0494-4712",
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T1 - Clinical value of serum uric acid in patients with suspected coronary artery disease

AU - Lim, Hong Euy

AU - Kim, Seong Hwan

AU - Kim, Eung Ju

AU - Kim, Jin Won

AU - Rha, Seung-Woon

AU - Seo, Hong G.

AU - Park, Chang Gyu

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Background/Aims: Although increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established. Methods: The study group comprised 687 consecutive patients with suspected CAD who had undergone coronary angiography. CAD was defined as stenosis ≥ 50% of the luminal diameter. CAD severity was expressed as 1-, 2-, or 3-vessel disease. Metabolic syndrome (MS) was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria, and aortofemoral pulse wave velocity (PWV) was obtained by arterial catheterization invasively. Results: In total, 395 patients had CAD. SUA was higher in patients with CAD as compared to those without CAD (5.5 ± 1.0 vs. 5.2 ± 1.0 mg/dL, p = 0.004). In addition, SUA was significantly associated with the severity of CAD (p = 0.002). However, after adjusting for significant confounding factors including age, diabetes, smoking, cholesterol, MS, and PWV, SUA was not an independent risk factor for CAD (p = 0.151). Based on a subgroup analysis, SUA was more closely associated with CAD in women than in men, and in the highest quartile (≥ 6.4 mg/dL) than in the first quartile (< 4.8 mg/dL); however, these results were not significant (p = 0.062, p = 0.075, respectively). In a multivariate regression analysis, the most important determinant of SUA was MS (i.e., insulin resistance syndrome), which is strongly associated with CAD. Conclusions: In patients with suspected CAD, SUA was not an independent risk factor for CAD and may be merely a marker of insulin resistance.

AB - Background/Aims: Although increased serum uric acid (SUA) concentrations are commonly encountered in patients with risk factors for coronary artery disease (CAD), the clinical value of SUA has not been established. Methods: The study group comprised 687 consecutive patients with suspected CAD who had undergone coronary angiography. CAD was defined as stenosis ≥ 50% of the luminal diameter. CAD severity was expressed as 1-, 2-, or 3-vessel disease. Metabolic syndrome (MS) was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria, and aortofemoral pulse wave velocity (PWV) was obtained by arterial catheterization invasively. Results: In total, 395 patients had CAD. SUA was higher in patients with CAD as compared to those without CAD (5.5 ± 1.0 vs. 5.2 ± 1.0 mg/dL, p = 0.004). In addition, SUA was significantly associated with the severity of CAD (p = 0.002). However, after adjusting for significant confounding factors including age, diabetes, smoking, cholesterol, MS, and PWV, SUA was not an independent risk factor for CAD (p = 0.151). Based on a subgroup analysis, SUA was more closely associated with CAD in women than in men, and in the highest quartile (≥ 6.4 mg/dL) than in the first quartile (< 4.8 mg/dL); however, these results were not significant (p = 0.062, p = 0.075, respectively). In a multivariate regression analysis, the most important determinant of SUA was MS (i.e., insulin resistance syndrome), which is strongly associated with CAD. Conclusions: In patients with suspected CAD, SUA was not an independent risk factor for CAD and may be merely a marker of insulin resistance.

KW - Coronary artery disease

KW - Insulin resistance

KW - Uric acid

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U2 - 10.3904/kjim.2010.25.1.21

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