Clinicopathologic characteristics of granulosa cell tumors of the ovary

A multicenter retrospective study

In Ho Lee, Chel Hun Choi, Dae Gy Hong, Jae Yun Song, Young Jae Kim, Kyung Tai Kim, Kyu Wan Lee, Il Soo Park, Duk Soo Bae, Tae Jin Kim

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objective: To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors. Methods: Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed. Results: One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies. Conclusion: Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalJournal of Gynecologic Oncology
Volume22
Issue number3
DOIs
Publication statusPublished - 2011 Sep 26

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Multicenter Studies
Retrospective Studies
Fertility
Recurrence
Premenopause
Granulosa cell tumor of the ovary
Granulosa Cell Tumor
Pregnancy
Adjuvant Chemotherapy
Disease-Free Survival
Medical Records
Cell Biology
Multivariate Analysis

Keywords

  • Clinical study
  • Granulosa cell tumor
  • Ovary
  • Pregnancy
  • Recurrence

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Clinicopathologic characteristics of granulosa cell tumors of the ovary : A multicenter retrospective study. / Lee, In Ho; Choi, Chel Hun; Hong, Dae Gy; Song, Jae Yun; Kim, Young Jae; Kim, Kyung Tai; Lee, Kyu Wan; Park, Il Soo; Bae, Duk Soo; Kim, Tae Jin.

In: Journal of Gynecologic Oncology, Vol. 22, No. 3, 26.09.2011, p. 188-195.

Research output: Contribution to journalArticle

Lee, In Ho ; Choi, Chel Hun ; Hong, Dae Gy ; Song, Jae Yun ; Kim, Young Jae ; Kim, Kyung Tai ; Lee, Kyu Wan ; Park, Il Soo ; Bae, Duk Soo ; Kim, Tae Jin. / Clinicopathologic characteristics of granulosa cell tumors of the ovary : A multicenter retrospective study. In: Journal of Gynecologic Oncology. 2011 ; Vol. 22, No. 3. pp. 188-195.
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abstract = "Objective: To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors. Methods: Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed. Results: One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies. Conclusion: Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.",
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AB - Objective: To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors. Methods: Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed. Results: One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies. Conclusion: Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.

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