Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of korean women: A korean gynecologic oncology group study

Ki Heon Lee, In Ho Lee, Byoung Gie Kim, Joo Hyun Nam, Won Kyu Kim, Soon Beom Kang, Sang Young Ryu, Chi Heum Cho, Ho Sun Choi, Kyung Tai Kim, Jae Kwan Lee, J. J. Park, M. S. Cha, J. H. Kim, J. M. Lee, S. Y. Park, S. C. Kim, S. K. Lee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

From January 1995 to December 2000, medical records of 196 patients were collected from 14 hospitals nationwide and were reviewed retrospectively. We evaluated the clinicopathologic characteristics of malignant germ cell tumors in the ovaries of South Korean women and determined the prognostic factors affecting recurrence. The mean patient age was 23.8 years (range, 4Y63 years), and the median follow-up period was 67 months (range, 1Y128 months). The distribution of the International Federation of Gynecology and Obstetrics stage was as follows: 128 cases (65.3%) in stage I, 27 cases (13.8%) in stage II, 39 cases (19.9%) in stage III, and 2 cases (1.0%) in stage IV. Histologically, immature teratoma was the most common tumor type (n = 68), followed by dysgerminoma (n = 54), endodermal sinus tumor (n = 38), mixed form (n = 24), and choriocarcinoma (n = 12). A fertility-sparing operation was performed in 134 patients, staging operation in 43 patients, and hysterectomy and bilateral salpingo-oophorectomy in 19 patients. Postoperative chemotherapy was administered in 166 patients, and the most common regimen was bleomycin, etoposide, and cisplatin (n = 120). Recurrence was observed in 13 patients (6.8%) and was influenced by the stage of the tumor and patient age (>40 years). The 5-year survival rate was 96.7%. During the follow-up period, 20 patients had 22 pregnancies that resulted in 17 normal deliveries at term and 5 abortions. The results of this study demonstrate that most malignant germ cell tumors of the ovary in Korean women are detected in the early stage and have excellent survival outcomes with conservative operation and platinum-based chemotherapy.

Original languageEnglish
Pages (from-to)84-87
Number of pages4
JournalInternational Journal of Gynecological Cancer
Volume19
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1
Externally publishedYes

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Germ Cell and Embryonal Neoplasms
Ovary
Dysgerminoma
Endodermal Sinus Tumor
Recurrence
Drug Therapy
Choriocarcinoma
Teratoma
Bleomycin
Ovariectomy
Etoposide
Platinum
Hysterectomy
Gynecology
Cisplatin
Obstetrics
Medical Records
Fertility
Neoplasms
Survival Rate

Keywords

  • Korean Gynecologic Oncology Group
  • Malignant germ cell tumor
  • Ovary
  • Recurrence
  • South Korea

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of korean women : A korean gynecologic oncology group study. / Lee, Ki Heon; Lee, In Ho; Kim, Byoung Gie; Nam, Joo Hyun; Kim, Won Kyu; Kang, Soon Beom; Ryu, Sang Young; Cho, Chi Heum; Choi, Ho Sun; Kim, Kyung Tai; Lee, Jae Kwan; Park, J. J.; Cha, M. S.; Kim, J. H.; Lee, J. M.; Park, S. Y.; Kim, S. C.; Lee, S. K.

In: International Journal of Gynecological Cancer, Vol. 19, No. 1, 01.01.2009, p. 84-87.

Research output: Contribution to journalArticle

Lee, KH, Lee, IH, Kim, BG, Nam, JH, Kim, WK, Kang, SB, Ryu, SY, Cho, CH, Choi, HS, Kim, KT, Lee, JK, Park, JJ, Cha, MS, Kim, JH, Lee, JM, Park, SY, Kim, SC & Lee, SK 2009, 'Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of korean women: A korean gynecologic oncology group study', International Journal of Gynecological Cancer, vol. 19, no. 1, pp. 84-87. https://doi.org/10.1111/IGC.0b013e31819914c5
Lee, Ki Heon ; Lee, In Ho ; Kim, Byoung Gie ; Nam, Joo Hyun ; Kim, Won Kyu ; Kang, Soon Beom ; Ryu, Sang Young ; Cho, Chi Heum ; Choi, Ho Sun ; Kim, Kyung Tai ; Lee, Jae Kwan ; Park, J. J. ; Cha, M. S. ; Kim, J. H. ; Lee, J. M. ; Park, S. Y. ; Kim, S. C. ; Lee, S. K. / Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of korean women : A korean gynecologic oncology group study. In: International Journal of Gynecological Cancer. 2009 ; Vol. 19, No. 1. pp. 84-87.
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