Abstract
Background: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. Methods: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. Results: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). Conclusion: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.
| Original language | English |
|---|---|
| Journal | Head and Neck |
| DOIs | |
| Publication status | Accepted/In press - 2015 |
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Keywords
- Grade
- Locoregional
- Parotid cancer
- Recurrence
- Survival
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers. / Lee, Doh Young; Park, Min Woo; Oh, Kyoung Ho; Cho, Jae-Gu; Kwon, Soon Young; Woo, Jeong-Soo; Jung, Kwang-Yoon; Baek, Seung-Kuk.
In: Head and Neck, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers
AU - Lee, Doh Young
AU - Park, Min Woo
AU - Oh, Kyoung Ho
AU - Cho, Jae-Gu
AU - Kwon, Soon Young
AU - Woo, Jeong-Soo
AU - Jung, Kwang-Yoon
AU - Baek, Seung-Kuk
PY - 2015
Y1 - 2015
N2 - Background: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. Methods: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. Results: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). Conclusion: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.
AB - Background: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. Methods: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. Results: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). Conclusion: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.
KW - Grade
KW - Locoregional
KW - Parotid cancer
KW - Recurrence
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84952701071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952701071&partnerID=8YFLogxK
U2 - 10.1002/hed.24316
DO - 10.1002/hed.24316
M3 - Article
C2 - 26698329
AN - SCOPUS:84952701071
JO - Head and Neck
JF - Head and Neck
SN - 1043-3074
ER -