Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers

Doh Young Lee, Min Woo Park, Kyoung Ho Oh, Jae-Gu Cho, Soon Young Kwon, Jeong-Soo Woo, Kwang-Yoon Jung, Seung-Kuk Baek

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5 Citations (Scopus)

Abstract

Background: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. Methods: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. Results: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). Conclusion: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Parotid Neoplasms
Recurrence
Neoplasms
Survival
Parotid Gland
Medical Records
Multivariate Analysis

Keywords

  • Grade
  • Locoregional
  • Parotid cancer
  • Recurrence
  • Survival

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{1c170ba0cea448e9864d87b979951a26,
title = "Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers",
abstract = "Background: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. Methods: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. Results: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3{\%}) and distant at high-grade cancer (13.6{\%}). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). Conclusion: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.",
keywords = "Grade, Locoregional, Parotid cancer, Recurrence, Survival",
author = "Lee, {Doh Young} and Park, {Min Woo} and Oh, {Kyoung Ho} and Jae-Gu Cho and Kwon, {Soon Young} and Jeong-Soo Woo and Kwang-Yoon Jung and Seung-Kuk Baek",
year = "2015",
doi = "10.1002/hed.24316",
language = "English",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Clinicopathologic factors associated with recurrence in low- and high-grade parotid cancers

AU - Lee, Doh Young

AU - Park, Min Woo

AU - Oh, Kyoung Ho

AU - Cho, Jae-Gu

AU - Kwon, Soon Young

AU - Woo, Jeong-Soo

AU - Jung, Kwang-Yoon

AU - Baek, Seung-Kuk

PY - 2015

Y1 - 2015

N2 - Background: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. Methods: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. Results: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). Conclusion: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.

AB - Background: The purpose of this study was to determine clinicopathological correlates of outcome among patients with parotid gland cancer. Methods: The medical records of 126 patients treated by surgery for localized parotid cancer were retrospectively reviewed to identify the clinicopathologic correlates of recurrence-free survival (RFS) according to histologic grade. Results: Multivariate analysis revealed that age and lymphovascular invasion were significant factors for recurrence in patients with low-grade cancer (p = .049 and p = .019, respectively), whereas perineural invasion was the only significant factor in patients with high-grade cancer (p = .001). The most frequent recurrence site tends to be different according to histologic grade: local recurrence at low-grade cancer (8.3%) and distant at high-grade cancer (13.6%). The duration of RFS was significantly longer in low-grade cancer than high-grade cancer in regional and distant recurrence (p = .044 and p = .016, respectively). Conclusion: Consideration of different factors may be required for individual low-grade and high-grade parotid cancers when predicting the risk of recurrence.

KW - Grade

KW - Locoregional

KW - Parotid cancer

KW - Recurrence

KW - Survival

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