Clinicopathologic findings of colorectal traditional and sessile serrated adenomas in Korea

A multicenter study

Sang Kil Lee, Hee Jin Chang, Tae Il Kim, Won Ho Kim, Cheol Keun Park, Dong Kyung Chang, Dong Il Park, Jin Hee Sohn, Jeong Sik Byeon, Suk Kyun Yang, Jin Oh Kim, Suk Ho Lee, So Young Jin, Cheol Hee Park, Il Hyun Baek, Chang Soo Eun, Dong Soo Han, Seun Ja Park, Hee Kyung Chang, Yoon Tae Jeen & 4 others Hyun Soo Kim, Dong Hoon Park, Sung Jae Shin, Mee Soo Chang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background/Aims: Serrated polyps have emerged as important evidence supporting the serrated polyp-neoplasia pathway in colorectal carcinogenesis, an alternate to the classical adenoma-carcinoma sequence. However, there is confusion over the diagnostic criteria for serrated polyps including traditional serrated adenoma (TSA) and sessile serrated adenoma (SSA). In addition, clinical and pathologic characteristics of each are largely unknown and need further exploration. Methods: The 753 polyps that were previously diagnosed as serrated adenoma (SA) from 14 tertiary care university hospitals in Korea between 2003 and 2005 were evaluated for the clinicopathologic findings of TSA and SSA. Results: Among 753 cases, 420 (55.8%) were reclassified as TSA and 56 (7.4%) as SSA. Among the pathologic parameters, crypt branching, crypt dilatation, and horizontal crypts were more frequent in SSA than in TSA (p < 0.001). SSA was larger than TSA (12.6 ± 7.3 vs. 9.8 ± 6.9 mm, p = 0.005), was more likely to be flat type (p = 0.006), and was more frequently located in the proximal colorectum (p = 0.012). There were no significant differences in age, sex, and body mass index between TSA and SSA. Conclusions: Locationand endoscopic features of the polyps with abnormal crypt morphology in histologic findings could be helpful for the diagnosis and classification of SAs.

Original languageEnglish
Pages (from-to)178-183
Number of pages6
JournalDigestion
Volume77
Issue number3-4
DOIs
Publication statusPublished - 2008 Aug 1

Fingerprint

Korea
Adenoma
Multicenter Studies
Polyps
Tertiary Healthcare
Dilatation
Carcinogenesis
Body Mass Index

Keywords

  • Sessile serrated adenomas
  • Traditional serrated adenomas

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lee, S. K., Chang, H. J., Kim, T. I., Kim, W. H., Park, C. K., Chang, D. K., ... Chang, M. S. (2008). Clinicopathologic findings of colorectal traditional and sessile serrated adenomas in Korea: A multicenter study. Digestion, 77(3-4), 178-183. https://doi.org/10.1159/000142077

Clinicopathologic findings of colorectal traditional and sessile serrated adenomas in Korea : A multicenter study. / Lee, Sang Kil; Chang, Hee Jin; Kim, Tae Il; Kim, Won Ho; Park, Cheol Keun; Chang, Dong Kyung; Park, Dong Il; Sohn, Jin Hee; Byeon, Jeong Sik; Yang, Suk Kyun; Kim, Jin Oh; Lee, Suk Ho; Jin, So Young; Park, Cheol Hee; Baek, Il Hyun; Eun, Chang Soo; Han, Dong Soo; Park, Seun Ja; Chang, Hee Kyung; Jeen, Yoon Tae; Kim, Hyun Soo; Park, Dong Hoon; Shin, Sung Jae; Chang, Mee Soo.

In: Digestion, Vol. 77, No. 3-4, 01.08.2008, p. 178-183.

Research output: Contribution to journalArticle

Lee, SK, Chang, HJ, Kim, TI, Kim, WH, Park, CK, Chang, DK, Park, DI, Sohn, JH, Byeon, JS, Yang, SK, Kim, JO, Lee, SH, Jin, SY, Park, CH, Baek, IH, Eun, CS, Han, DS, Park, SJ, Chang, HK, Jeen, YT, Kim, HS, Park, DH, Shin, SJ & Chang, MS 2008, 'Clinicopathologic findings of colorectal traditional and sessile serrated adenomas in Korea: A multicenter study', Digestion, vol. 77, no. 3-4, pp. 178-183. https://doi.org/10.1159/000142077
Lee, Sang Kil ; Chang, Hee Jin ; Kim, Tae Il ; Kim, Won Ho ; Park, Cheol Keun ; Chang, Dong Kyung ; Park, Dong Il ; Sohn, Jin Hee ; Byeon, Jeong Sik ; Yang, Suk Kyun ; Kim, Jin Oh ; Lee, Suk Ho ; Jin, So Young ; Park, Cheol Hee ; Baek, Il Hyun ; Eun, Chang Soo ; Han, Dong Soo ; Park, Seun Ja ; Chang, Hee Kyung ; Jeen, Yoon Tae ; Kim, Hyun Soo ; Park, Dong Hoon ; Shin, Sung Jae ; Chang, Mee Soo. / Clinicopathologic findings of colorectal traditional and sessile serrated adenomas in Korea : A multicenter study. In: Digestion. 2008 ; Vol. 77, No. 3-4. pp. 178-183.
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abstract = "Background/Aims: Serrated polyps have emerged as important evidence supporting the serrated polyp-neoplasia pathway in colorectal carcinogenesis, an alternate to the classical adenoma-carcinoma sequence. However, there is confusion over the diagnostic criteria for serrated polyps including traditional serrated adenoma (TSA) and sessile serrated adenoma (SSA). In addition, clinical and pathologic characteristics of each are largely unknown and need further exploration. Methods: The 753 polyps that were previously diagnosed as serrated adenoma (SA) from 14 tertiary care university hospitals in Korea between 2003 and 2005 were evaluated for the clinicopathologic findings of TSA and SSA. Results: Among 753 cases, 420 (55.8{\%}) were reclassified as TSA and 56 (7.4{\%}) as SSA. Among the pathologic parameters, crypt branching, crypt dilatation, and horizontal crypts were more frequent in SSA than in TSA (p < 0.001). SSA was larger than TSA (12.6 ± 7.3 vs. 9.8 ± 6.9 mm, p = 0.005), was more likely to be flat type (p = 0.006), and was more frequently located in the proximal colorectum (p = 0.012). There were no significant differences in age, sex, and body mass index between TSA and SSA. Conclusions: Locationand endoscopic features of the polyps with abnormal crypt morphology in histologic findings could be helpful for the diagnosis and classification of SAs.",
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T1 - Clinicopathologic findings of colorectal traditional and sessile serrated adenomas in Korea

T2 - A multicenter study

AU - Lee, Sang Kil

AU - Chang, Hee Jin

AU - Kim, Tae Il

AU - Kim, Won Ho

AU - Park, Cheol Keun

AU - Chang, Dong Kyung

AU - Park, Dong Il

AU - Sohn, Jin Hee

AU - Byeon, Jeong Sik

AU - Yang, Suk Kyun

AU - Kim, Jin Oh

AU - Lee, Suk Ho

AU - Jin, So Young

AU - Park, Cheol Hee

AU - Baek, Il Hyun

AU - Eun, Chang Soo

AU - Han, Dong Soo

AU - Park, Seun Ja

AU - Chang, Hee Kyung

AU - Jeen, Yoon Tae

AU - Kim, Hyun Soo

AU - Park, Dong Hoon

AU - Shin, Sung Jae

AU - Chang, Mee Soo

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Background/Aims: Serrated polyps have emerged as important evidence supporting the serrated polyp-neoplasia pathway in colorectal carcinogenesis, an alternate to the classical adenoma-carcinoma sequence. However, there is confusion over the diagnostic criteria for serrated polyps including traditional serrated adenoma (TSA) and sessile serrated adenoma (SSA). In addition, clinical and pathologic characteristics of each are largely unknown and need further exploration. Methods: The 753 polyps that were previously diagnosed as serrated adenoma (SA) from 14 tertiary care university hospitals in Korea between 2003 and 2005 were evaluated for the clinicopathologic findings of TSA and SSA. Results: Among 753 cases, 420 (55.8%) were reclassified as TSA and 56 (7.4%) as SSA. Among the pathologic parameters, crypt branching, crypt dilatation, and horizontal crypts were more frequent in SSA than in TSA (p < 0.001). SSA was larger than TSA (12.6 ± 7.3 vs. 9.8 ± 6.9 mm, p = 0.005), was more likely to be flat type (p = 0.006), and was more frequently located in the proximal colorectum (p = 0.012). There were no significant differences in age, sex, and body mass index between TSA and SSA. Conclusions: Locationand endoscopic features of the polyps with abnormal crypt morphology in histologic findings could be helpful for the diagnosis and classification of SAs.

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