Clinicopathologic implications of tissue inhibitor of metalloproteinase-1- positive diffuse large B-cell lymphoma

Jung-Woo Choi, Jung Suk An, Ju-Han Lee, Eung Seok Lee, Kwang Hee Kim, Young Sik Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The tissue inhibitor of metalloproteinase-1 (TIMP-1) is a stromal factor that promotes plasmablastic differentiation, and the survival of germinal center B-cells. The expression of TIMP-1 is known to be correlated with a subset of non-Hodgkin lymphoma at the mRNA level, and Epstein-Barr virus infection in vitro. To characterize TIMP-1(+) diffuse large B-cell lymphoma, TIMP-1 expression was investigated in tissue microarrays from 182 cases of de novo diffuse large B-cell lymphoma and compared with prognostic factors, immunophenotypes, and Epstein-Barr virus infection status. TIMP-1 was expressed not only in tumor cells themselves, in 14 of 182 cases (8%), designated as TIMP-1(+) diffuse large B-cell lymphoma, but also in stromal cells like fibroblasts and endothelial cells. In univariate analysis and hierarchical clustering, our findings suggest that TIMP-1 expression may represent a distinct subgroup. In multivariate analysis, TIMP-1(+) diffuse large B-cell lymphoma (n=14) was associated with unfavorable outcomes compared to TIMP-1(-) diffuse large B-cell lymphoma (n=168) (odds ratio=2.5, P=0.049). Together with TIMP-1 expression, age (greater than 60 years), the presence of B-symptoms, abnormal lactate dehydrogenase level, or more advanced stage (III/IV) was correlated with a poor overall survival. However, TIMP-1 expression in diffuse large B-cell lymphoma was not correlated with other prognostic factors including: clinical stage, international prognostic index score, and nongerminal center B-cell phenotype, as well as Epstein-Barr virus infection. Our results suggest that TIMP-1 expression may be an independent negative prognostic factor in patients with diffuse large B-cell lymphoma.

Original languageEnglish
Pages (from-to)963-973
Number of pages11
JournalModern Pathology
Volume19
Issue number7
DOIs
Publication statusPublished - 2006 Jul 28

Fingerprint

Tissue Inhibitor of Metalloproteinase-1
Lymphoma, Large B-Cell, Diffuse
Epstein-Barr Virus Infections
B-Lymphocytes
Germinal Center
Stromal Cells
L-Lactate Dehydrogenase
Non-Hodgkin's Lymphoma
Cluster Analysis
Multivariate Analysis
Endothelial Cells
Fibroblasts
Odds Ratio

Keywords

  • Non-Hodgkin lymphoma
  • TIMP-1
  • Tissue microarray

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Clinicopathologic implications of tissue inhibitor of metalloproteinase-1- positive diffuse large B-cell lymphoma. / Choi, Jung-Woo; An, Jung Suk; Lee, Ju-Han; Lee, Eung Seok; Kim, Kwang Hee; Kim, Young Sik.

In: Modern Pathology, Vol. 19, No. 7, 28.07.2006, p. 963-973.

Research output: Contribution to journalArticle

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