Clinicopathologic Risk factors for the local recurrence of phyllodes tumors of the breast

Jae Hyuck Jang, Min Young Choi, Se Kyung Lee, Sangmin Kim, Jiyoung Kim, Jeonghui Lee, Seung Pil Jung, Jun Ho Choe, Jung Han Kim, Jee Soo Kim, Eun Yoon Cho, Jeong Eon Lee, Seok Jin Nam, Jung Hyun Yang

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Abstract

Background: Phyllodes tumors (PTs) are rare breast tumors that usually occur in middle-aged women. Here we discuss our recent experiences in the diagnosis, surgical management, and clinical follow-up of this disease. Methods: We retrospectively reviewed 164 patients with PTs who underwent surgical treatment at the Department of Surgery, Samsung Medical Center, Seoul, Korea, from January 1995 to July 2009. Clinical and histopathological data were analyzed. Results: The median follow-up period was 33.6 months (range 2-179 months), and the median patient age was 43 years (range of 11-72 years). Tumor size ranged from 1 to 30 cm, with a median of 6.1 cm. A total of 148 patients (90.2 %) received local or wide excisions. Mastectomies were performed in 16 patients (9.8 %). The pathologic diagnoses included 82 benign (50.0 %), 42 borderline (25.6 %), and 40 malignant PTs (24.4 %). The tumor border was infiltrating in 43 patients (26.2 %) and pushing in 116 patients (70.7 %). The resection margin was divided by based on the width. Local recurrence was observed in 31 patients (18.9 %), and distant metastasis developed in four patients with malignant PTs. Risk factors for the local recurrence of a PT were a positive resection margin (P = .029) and tumor size (P = .001). Conclusions: The presence of tumor cells on the resection margin was a strong prognostic factor for local recurrence of PTs. However, a 1 cm negative margin thickness did not confer any local control advantage over a thinner negative margin width.

Original languageEnglish
Pages (from-to)2612-2617
Number of pages6
JournalAnnals of Surgical Oncology
Volume19
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1
Externally publishedYes

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Phyllodes Tumor
Breast
Recurrence
Neoplasms
Mastectomy
Korea
Breast Neoplasms
Neoplasm Metastasis

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Jang, J. H., Choi, M. Y., Lee, S. K., Kim, S., Kim, J., Lee, J., ... Yang, J. H. (2012). Clinicopathologic Risk factors for the local recurrence of phyllodes tumors of the breast. Annals of Surgical Oncology, 19(8), 2612-2617. https://doi.org/10.1245/s10434-012-2307-5

Clinicopathologic Risk factors for the local recurrence of phyllodes tumors of the breast. / Jang, Jae Hyuck; Choi, Min Young; Lee, Se Kyung; Kim, Sangmin; Kim, Jiyoung; Lee, Jeonghui; Jung, Seung Pil; Choe, Jun Ho; Kim, Jung Han; Kim, Jee Soo; Cho, Eun Yoon; Lee, Jeong Eon; Nam, Seok Jin; Yang, Jung Hyun.

In: Annals of Surgical Oncology, Vol. 19, No. 8, 01.08.2012, p. 2612-2617.

Research output: Contribution to journalArticle

Jang, JH, Choi, MY, Lee, SK, Kim, S, Kim, J, Lee, J, Jung, SP, Choe, JH, Kim, JH, Kim, JS, Cho, EY, Lee, JE, Nam, SJ & Yang, JH 2012, 'Clinicopathologic Risk factors for the local recurrence of phyllodes tumors of the breast', Annals of Surgical Oncology, vol. 19, no. 8, pp. 2612-2617. https://doi.org/10.1245/s10434-012-2307-5
Jang, Jae Hyuck ; Choi, Min Young ; Lee, Se Kyung ; Kim, Sangmin ; Kim, Jiyoung ; Lee, Jeonghui ; Jung, Seung Pil ; Choe, Jun Ho ; Kim, Jung Han ; Kim, Jee Soo ; Cho, Eun Yoon ; Lee, Jeong Eon ; Nam, Seok Jin ; Yang, Jung Hyun. / Clinicopathologic Risk factors for the local recurrence of phyllodes tumors of the breast. In: Annals of Surgical Oncology. 2012 ; Vol. 19, No. 8. pp. 2612-2617.
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abstract = "Background: Phyllodes tumors (PTs) are rare breast tumors that usually occur in middle-aged women. Here we discuss our recent experiences in the diagnosis, surgical management, and clinical follow-up of this disease. Methods: We retrospectively reviewed 164 patients with PTs who underwent surgical treatment at the Department of Surgery, Samsung Medical Center, Seoul, Korea, from January 1995 to July 2009. Clinical and histopathological data were analyzed. Results: The median follow-up period was 33.6 months (range 2-179 months), and the median patient age was 43 years (range of 11-72 years). Tumor size ranged from 1 to 30 cm, with a median of 6.1 cm. A total of 148 patients (90.2 {\%}) received local or wide excisions. Mastectomies were performed in 16 patients (9.8 {\%}). The pathologic diagnoses included 82 benign (50.0 {\%}), 42 borderline (25.6 {\%}), and 40 malignant PTs (24.4 {\%}). The tumor border was infiltrating in 43 patients (26.2 {\%}) and pushing in 116 patients (70.7 {\%}). The resection margin was divided by based on the width. Local recurrence was observed in 31 patients (18.9 {\%}), and distant metastasis developed in four patients with malignant PTs. Risk factors for the local recurrence of a PT were a positive resection margin (P = .029) and tumor size (P = .001). Conclusions: The presence of tumor cells on the resection margin was a strong prognostic factor for local recurrence of PTs. However, a 1 cm negative margin thickness did not confer any local control advantage over a thinner negative margin width.",
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AU - Choi, Min Young

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AU - Kim, Sangmin

AU - Kim, Jiyoung

AU - Lee, Jeonghui

AU - Jung, Seung Pil

AU - Choe, Jun Ho

AU - Kim, Jung Han

AU - Kim, Jee Soo

AU - Cho, Eun Yoon

AU - Lee, Jeong Eon

AU - Nam, Seok Jin

AU - Yang, Jung Hyun

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N2 - Background: Phyllodes tumors (PTs) are rare breast tumors that usually occur in middle-aged women. Here we discuss our recent experiences in the diagnosis, surgical management, and clinical follow-up of this disease. Methods: We retrospectively reviewed 164 patients with PTs who underwent surgical treatment at the Department of Surgery, Samsung Medical Center, Seoul, Korea, from January 1995 to July 2009. Clinical and histopathological data were analyzed. Results: The median follow-up period was 33.6 months (range 2-179 months), and the median patient age was 43 years (range of 11-72 years). Tumor size ranged from 1 to 30 cm, with a median of 6.1 cm. A total of 148 patients (90.2 %) received local or wide excisions. Mastectomies were performed in 16 patients (9.8 %). The pathologic diagnoses included 82 benign (50.0 %), 42 borderline (25.6 %), and 40 malignant PTs (24.4 %). The tumor border was infiltrating in 43 patients (26.2 %) and pushing in 116 patients (70.7 %). The resection margin was divided by based on the width. Local recurrence was observed in 31 patients (18.9 %), and distant metastasis developed in four patients with malignant PTs. Risk factors for the local recurrence of a PT were a positive resection margin (P = .029) and tumor size (P = .001). Conclusions: The presence of tumor cells on the resection margin was a strong prognostic factor for local recurrence of PTs. However, a 1 cm negative margin thickness did not confer any local control advantage over a thinner negative margin width.

AB - Background: Phyllodes tumors (PTs) are rare breast tumors that usually occur in middle-aged women. Here we discuss our recent experiences in the diagnosis, surgical management, and clinical follow-up of this disease. Methods: We retrospectively reviewed 164 patients with PTs who underwent surgical treatment at the Department of Surgery, Samsung Medical Center, Seoul, Korea, from January 1995 to July 2009. Clinical and histopathological data were analyzed. Results: The median follow-up period was 33.6 months (range 2-179 months), and the median patient age was 43 years (range of 11-72 years). Tumor size ranged from 1 to 30 cm, with a median of 6.1 cm. A total of 148 patients (90.2 %) received local or wide excisions. Mastectomies were performed in 16 patients (9.8 %). The pathologic diagnoses included 82 benign (50.0 %), 42 borderline (25.6 %), and 40 malignant PTs (24.4 %). The tumor border was infiltrating in 43 patients (26.2 %) and pushing in 116 patients (70.7 %). The resection margin was divided by based on the width. Local recurrence was observed in 31 patients (18.9 %), and distant metastasis developed in four patients with malignant PTs. Risk factors for the local recurrence of a PT were a positive resection margin (P = .029) and tumor size (P = .001). Conclusions: The presence of tumor cells on the resection margin was a strong prognostic factor for local recurrence of PTs. However, a 1 cm negative margin thickness did not confer any local control advantage over a thinner negative margin width.

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