Clinicopathologic significance of nuclear grooves and inclusions in renal cell carcinoma: Image database construction and quantitative scoring

Ju-Han Lee, Eun Mee Han, Zhen Hua Lin, Zheng Sheng Wu, Eung Seok Lee, Young Sik Kim

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8 Citations (Scopus)

Abstract

Context.-Nuclear grooves and inclusions are major features of cancer. However, the nuclear irregularities in renal cell carcinoma (RCC) have not yet been well characterized. Objective.-To determine the clinicopathologic significance of nuclear grooves and inclusions in RCC. Design.-The frequencies or scores of nuclear grooves and inclusions were compared with the histologic subtype, nuclear grade, and TNM stage, as well as overall survival of RCC patients. For objective counting of nuclear irregularities, a relational image database was constructed and used for quantitative assessment. Results.-Nuclear grooves and inclusions were seen in 96% and 65% of 110 RCC cases, respectively. The intranuclear inclusions were found more frequently in chromophobe and papillary types than in clear cell carcinoma (P < .001). The nuclear scores, the sum of grooves or inclusions per 5000 tumor cells, were highly related to the histologic subtype (P < .001). Clear cell RCCs with high inclusion scores (2 or more) were correlated with poorer overall survival in comparison to clear cell carcinomas with low inclusion scores (P = .04). The groove scores were highly associated with Fuhrman grade (P = .003) but not with overall survival of clear cell RCC patients (P = .65). In multivariate analysis, higher inclusion scores and advanced tumor stages (lll/IV) were correlated with worse outcomes of clear cell RCC. Conclusions.-Nuclear grooves and inclusions are histologic components of RCCs, especially chromophobe and papillary carcinomas. Furthermore, nuclear inclusions might be an independent prognostic factor for clear cell RCC.

Original languageEnglish
Pages (from-to)940-946
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Volume132
Issue number6
Publication statusPublished - 2008 Jun 1

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Intranuclear Inclusion Bodies
Renal Cell Carcinoma
Databases
Survival
Carcinoma
Neoplasms
Papillary Carcinoma
Multivariate Analysis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Medicine(all)

Cite this

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title = "Clinicopathologic significance of nuclear grooves and inclusions in renal cell carcinoma: Image database construction and quantitative scoring",
abstract = "Context.-Nuclear grooves and inclusions are major features of cancer. However, the nuclear irregularities in renal cell carcinoma (RCC) have not yet been well characterized. Objective.-To determine the clinicopathologic significance of nuclear grooves and inclusions in RCC. Design.-The frequencies or scores of nuclear grooves and inclusions were compared with the histologic subtype, nuclear grade, and TNM stage, as well as overall survival of RCC patients. For objective counting of nuclear irregularities, a relational image database was constructed and used for quantitative assessment. Results.-Nuclear grooves and inclusions were seen in 96{\%} and 65{\%} of 110 RCC cases, respectively. The intranuclear inclusions were found more frequently in chromophobe and papillary types than in clear cell carcinoma (P < .001). The nuclear scores, the sum of grooves or inclusions per 5000 tumor cells, were highly related to the histologic subtype (P < .001). Clear cell RCCs with high inclusion scores (2 or more) were correlated with poorer overall survival in comparison to clear cell carcinomas with low inclusion scores (P = .04). The groove scores were highly associated with Fuhrman grade (P = .003) but not with overall survival of clear cell RCC patients (P = .65). In multivariate analysis, higher inclusion scores and advanced tumor stages (lll/IV) were correlated with worse outcomes of clear cell RCC. Conclusions.-Nuclear grooves and inclusions are histologic components of RCCs, especially chromophobe and papillary carcinomas. Furthermore, nuclear inclusions might be an independent prognostic factor for clear cell RCC.",
author = "Ju-Han Lee and Han, {Eun Mee} and Lin, {Zhen Hua} and Wu, {Zheng Sheng} and Lee, {Eung Seok} and Kim, {Young Sik}",
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T1 - Clinicopathologic significance of nuclear grooves and inclusions in renal cell carcinoma

T2 - Image database construction and quantitative scoring

AU - Lee, Ju-Han

AU - Han, Eun Mee

AU - Lin, Zhen Hua

AU - Wu, Zheng Sheng

AU - Lee, Eung Seok

AU - Kim, Young Sik

PY - 2008/6/1

Y1 - 2008/6/1

N2 - Context.-Nuclear grooves and inclusions are major features of cancer. However, the nuclear irregularities in renal cell carcinoma (RCC) have not yet been well characterized. Objective.-To determine the clinicopathologic significance of nuclear grooves and inclusions in RCC. Design.-The frequencies or scores of nuclear grooves and inclusions were compared with the histologic subtype, nuclear grade, and TNM stage, as well as overall survival of RCC patients. For objective counting of nuclear irregularities, a relational image database was constructed and used for quantitative assessment. Results.-Nuclear grooves and inclusions were seen in 96% and 65% of 110 RCC cases, respectively. The intranuclear inclusions were found more frequently in chromophobe and papillary types than in clear cell carcinoma (P < .001). The nuclear scores, the sum of grooves or inclusions per 5000 tumor cells, were highly related to the histologic subtype (P < .001). Clear cell RCCs with high inclusion scores (2 or more) were correlated with poorer overall survival in comparison to clear cell carcinomas with low inclusion scores (P = .04). The groove scores were highly associated with Fuhrman grade (P = .003) but not with overall survival of clear cell RCC patients (P = .65). In multivariate analysis, higher inclusion scores and advanced tumor stages (lll/IV) were correlated with worse outcomes of clear cell RCC. Conclusions.-Nuclear grooves and inclusions are histologic components of RCCs, especially chromophobe and papillary carcinomas. Furthermore, nuclear inclusions might be an independent prognostic factor for clear cell RCC.

AB - Context.-Nuclear grooves and inclusions are major features of cancer. However, the nuclear irregularities in renal cell carcinoma (RCC) have not yet been well characterized. Objective.-To determine the clinicopathologic significance of nuclear grooves and inclusions in RCC. Design.-The frequencies or scores of nuclear grooves and inclusions were compared with the histologic subtype, nuclear grade, and TNM stage, as well as overall survival of RCC patients. For objective counting of nuclear irregularities, a relational image database was constructed and used for quantitative assessment. Results.-Nuclear grooves and inclusions were seen in 96% and 65% of 110 RCC cases, respectively. The intranuclear inclusions were found more frequently in chromophobe and papillary types than in clear cell carcinoma (P < .001). The nuclear scores, the sum of grooves or inclusions per 5000 tumor cells, were highly related to the histologic subtype (P < .001). Clear cell RCCs with high inclusion scores (2 or more) were correlated with poorer overall survival in comparison to clear cell carcinomas with low inclusion scores (P = .04). The groove scores were highly associated with Fuhrman grade (P = .003) but not with overall survival of clear cell RCC patients (P = .65). In multivariate analysis, higher inclusion scores and advanced tumor stages (lll/IV) were correlated with worse outcomes of clear cell RCC. Conclusions.-Nuclear grooves and inclusions are histologic components of RCCs, especially chromophobe and papillary carcinomas. Furthermore, nuclear inclusions might be an independent prognostic factor for clear cell RCC.

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