Abstract
Background: Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group. Methods: We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports. Results: Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for ß-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA. Conclusions: Although the new classification is now generally accepted, validation through follow-up studies is necessary.
| Original language | English |
|---|---|
| Pages (from-to) | 411-417 |
| Number of pages | 7 |
| Journal | Korean Journal of Pathology |
| Volume | 47 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2013 Nov 19 |
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Keywords
- Adenoma
- Beta catenin
- Hepatocyte nuclear factor 1-alpha
- Liver cell
- Serum amyloid A protein
- Subtype
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Clinicopathological analysis of hepatocellular adenoma according to new Bordeaux classification : Report of eight Korean cases. / Kim, Hyunchul; Jang, Ja June; Kim, Dong-Sik; Yeom, Beom Woo; Won, Nam Hee.
In: Korean Journal of Pathology, Vol. 47, No. 5, 19.11.2013, p. 411-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clinicopathological analysis of hepatocellular adenoma according to new Bordeaux classification
T2 - Report of eight Korean cases
AU - Kim, Hyunchul
AU - Jang, Ja June
AU - Kim, Dong-Sik
AU - Yeom, Beom Woo
AU - Won, Nam Hee
PY - 2013/11/19
Y1 - 2013/11/19
N2 - Background: Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group. Methods: We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports. Results: Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for ß-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA. Conclusions: Although the new classification is now generally accepted, validation through follow-up studies is necessary.
AB - Background: Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group. Methods: We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports. Results: Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for ß-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA. Conclusions: Although the new classification is now generally accepted, validation through follow-up studies is necessary.
KW - Adenoma
KW - Beta catenin
KW - Hepatocyte nuclear factor 1-alpha
KW - Liver cell
KW - Serum amyloid A protein
KW - Subtype
UR - http://www.scopus.com/inward/record.url?scp=84887548055&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887548055&partnerID=8YFLogxK
U2 - 10.4132/KoreanJPathol.2013.47.5.411
DO - 10.4132/KoreanJPathol.2013.47.5.411
M3 - Article
VL - 47
SP - 411
EP - 417
JO - Journal of Pathology and Translational Medicine
JF - Journal of Pathology and Translational Medicine
SN - 2383-7837
IS - 5
ER -