Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: A meta-analysis

Ju-Han Lee, Seo Hee Kim, Sun Hee Han, Jung Suk An, Eung Seok Lee, Young Sik Kim

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

There is conflicting data regarding the clinicopathological significance of the risk factors associated with Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC). To address this controversy, we performed a meta-analysis for the clinicopathological and molecular characteristics of EBVaGC. The relevant published studies were reviewed according to the defined selection criteria. The effect sizes of the outcome parameters were estimated by an odds ratio or a weighted mean difference. This meta-analysis included 48 studies that encompassed a total of 9738 patients. The frequency of EBVaGC was 8.8%, and EBVaGC was significantly associated with ethnicity. It was more predominant in men and in younger individuals. Interestingly, EBVaGC was more prevalent in Caucasian and Hispanic patients than in Asian ones. EBVaGC developed most often in the cardia and body, and it generally showed the diffuse histological type. EBV was highly prevalent in the patients with lymphoepithelial carcinoma. EBVaGC was closely associated with remnant cancer and a CpG island methylator-high status, but not with Helicobacter pylori infection, a TP53 expression, and p53 mutation. In addition, EBVaGC was not significantly associated with the depth of invasion, lymph node metastasis, or the clinical stage. The clinicopathological and molecular characteristics of EBVaGC are quite different from those of conventional gastric adenocarcinoma. However, further study is needed to determine the effect of EBV on the survival of EBVaGC patients.

Original languageEnglish
Pages (from-to)354-365
Number of pages12
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume24
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1

Fingerprint

Human Herpesvirus 4
Meta-Analysis
Stomach
Carcinoma
Cardia
CpG Islands
Helicobacter Infections
Hispanic Americans
Helicobacter pylori
Patient Selection
Adenocarcinoma
Lymph Nodes
Odds Ratio
Neoplasm Metastasis
Mutation

Keywords

  • Adenocarcinoma
  • Epstein-Barr virus
  • Meta-analysis
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma : A meta-analysis. / Lee, Ju-Han; Kim, Seo Hee; Han, Sun Hee; An, Jung Suk; Lee, Eung Seok; Kim, Young Sik.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 24, No. 3, 01.03.2009, p. 354-365.

Research output: Contribution to journalArticle

@article{97a56cd4911b44a8bb918328f107c183,
title = "Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: A meta-analysis",
abstract = "There is conflicting data regarding the clinicopathological significance of the risk factors associated with Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC). To address this controversy, we performed a meta-analysis for the clinicopathological and molecular characteristics of EBVaGC. The relevant published studies were reviewed according to the defined selection criteria. The effect sizes of the outcome parameters were estimated by an odds ratio or a weighted mean difference. This meta-analysis included 48 studies that encompassed a total of 9738 patients. The frequency of EBVaGC was 8.8{\%}, and EBVaGC was significantly associated with ethnicity. It was more predominant in men and in younger individuals. Interestingly, EBVaGC was more prevalent in Caucasian and Hispanic patients than in Asian ones. EBVaGC developed most often in the cardia and body, and it generally showed the diffuse histological type. EBV was highly prevalent in the patients with lymphoepithelial carcinoma. EBVaGC was closely associated with remnant cancer and a CpG island methylator-high status, but not with Helicobacter pylori infection, a TP53 expression, and p53 mutation. In addition, EBVaGC was not significantly associated with the depth of invasion, lymph node metastasis, or the clinical stage. The clinicopathological and molecular characteristics of EBVaGC are quite different from those of conventional gastric adenocarcinoma. However, further study is needed to determine the effect of EBV on the survival of EBVaGC patients.",
keywords = "Adenocarcinoma, Epstein-Barr virus, Meta-analysis, Stomach",
author = "Ju-Han Lee and Kim, {Seo Hee} and Han, {Sun Hee} and An, {Jung Suk} and Lee, {Eung Seok} and Kim, {Young Sik}",
year = "2009",
month = "3",
day = "1",
doi = "10.1111/j.1440-1746.2009.05775.x",
language = "English",
volume = "24",
pages = "354--365",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma

T2 - A meta-analysis

AU - Lee, Ju-Han

AU - Kim, Seo Hee

AU - Han, Sun Hee

AU - An, Jung Suk

AU - Lee, Eung Seok

AU - Kim, Young Sik

PY - 2009/3/1

Y1 - 2009/3/1

N2 - There is conflicting data regarding the clinicopathological significance of the risk factors associated with Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC). To address this controversy, we performed a meta-analysis for the clinicopathological and molecular characteristics of EBVaGC. The relevant published studies were reviewed according to the defined selection criteria. The effect sizes of the outcome parameters were estimated by an odds ratio or a weighted mean difference. This meta-analysis included 48 studies that encompassed a total of 9738 patients. The frequency of EBVaGC was 8.8%, and EBVaGC was significantly associated with ethnicity. It was more predominant in men and in younger individuals. Interestingly, EBVaGC was more prevalent in Caucasian and Hispanic patients than in Asian ones. EBVaGC developed most often in the cardia and body, and it generally showed the diffuse histological type. EBV was highly prevalent in the patients with lymphoepithelial carcinoma. EBVaGC was closely associated with remnant cancer and a CpG island methylator-high status, but not with Helicobacter pylori infection, a TP53 expression, and p53 mutation. In addition, EBVaGC was not significantly associated with the depth of invasion, lymph node metastasis, or the clinical stage. The clinicopathological and molecular characteristics of EBVaGC are quite different from those of conventional gastric adenocarcinoma. However, further study is needed to determine the effect of EBV on the survival of EBVaGC patients.

AB - There is conflicting data regarding the clinicopathological significance of the risk factors associated with Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC). To address this controversy, we performed a meta-analysis for the clinicopathological and molecular characteristics of EBVaGC. The relevant published studies were reviewed according to the defined selection criteria. The effect sizes of the outcome parameters were estimated by an odds ratio or a weighted mean difference. This meta-analysis included 48 studies that encompassed a total of 9738 patients. The frequency of EBVaGC was 8.8%, and EBVaGC was significantly associated with ethnicity. It was more predominant in men and in younger individuals. Interestingly, EBVaGC was more prevalent in Caucasian and Hispanic patients than in Asian ones. EBVaGC developed most often in the cardia and body, and it generally showed the diffuse histological type. EBV was highly prevalent in the patients with lymphoepithelial carcinoma. EBVaGC was closely associated with remnant cancer and a CpG island methylator-high status, but not with Helicobacter pylori infection, a TP53 expression, and p53 mutation. In addition, EBVaGC was not significantly associated with the depth of invasion, lymph node metastasis, or the clinical stage. The clinicopathological and molecular characteristics of EBVaGC are quite different from those of conventional gastric adenocarcinoma. However, further study is needed to determine the effect of EBV on the survival of EBVaGC patients.

KW - Adenocarcinoma

KW - Epstein-Barr virus

KW - Meta-analysis

KW - Stomach

UR - http://www.scopus.com/inward/record.url?scp=63049096036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63049096036&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1746.2009.05775.x

DO - 10.1111/j.1440-1746.2009.05775.x

M3 - Article

C2 - 19335785

AN - SCOPUS:63049096036

VL - 24

SP - 354

EP - 365

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 3

ER -