CLOCK gene 3111C/T polymorphism is not associated with seasonal variations in mood and behavior in Korean college students

Jong Woo Paik; Heon Jeong Lee; Seong Gul Kang; Se Won Lim; Min Soo Lee; Leen Kim

doi:10.1111/j.1440-1819.2007.01621.x

CLOCK gene 3111C/T polymorphism is not associated with seasonal variations in mood and behavior in Korean college students

Jong Woo Paik, Heon Jeong Lee, Seong Gul Kang, Se Won Lim, Min Soo Lee, Leen Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The present study tested the potential association between the 3111C/T polymorphism of the CLOCK gene and seasonal variations in mood and behavior. A total of 297 Korean college students were genotyped for the CLOCK polymorphism and the seasonal variation was evaluated using the Seasonal Pattern Assessment Questionnaire (SPAQ). The seasonality scores were not different between CLOCK gene variants (P > 0.05). Comparison between seasonals (syndromal plus subsyndromal seasonal affective disorder according to SPAQ) and non-seasonals found no significant difference in frequencies of genotypes (P > 0.05). These findings suggest that the CLOCK polymorphism does not play a major role in susceptibility to seasonal variations in a Korean population.

Original language	English
Pages (from-to)	124-126
Number of pages	3
Journal	Psychiatry and Clinical Neurosciences
Volume	61
Issue number	1
DOIs	https://doi.org/10.1111/j.1440-1819.2007.01621.x
Publication status	Published - 2007 Feb

Keywords

CLOCK
Genetic association
Polymorphism
Seasonal affective disorder

ASJC Scopus subject areas

Neuroscience(all)
Neurology
Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1440-1819.2007.01621.x

Cite this

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title = "CLOCK gene 3111C/T polymorphism is not associated with seasonal variations in mood and behavior in Korean college students",

abstract = "The present study tested the potential association between the 3111C/T polymorphism of the CLOCK gene and seasonal variations in mood and behavior. A total of 297 Korean college students were genotyped for the CLOCK polymorphism and the seasonal variation was evaluated using the Seasonal Pattern Assessment Questionnaire (SPAQ). The seasonality scores were not different between CLOCK gene variants (P > 0.05). Comparison between seasonals (syndromal plus subsyndromal seasonal affective disorder according to SPAQ) and non-seasonals found no significant difference in frequencies of genotypes (P > 0.05). These findings suggest that the CLOCK polymorphism does not play a major role in susceptibility to seasonal variations in a Korean population.",

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author = "Paik, {Jong Woo} and Lee, {Heon Jeong} and Kang, {Seong Gul} and Lim, {Se Won} and Lee, {Min Soo} and Leen Kim",

year = "2007",

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doi = "10.1111/j.1440-1819.2007.01621.x",

language = "English",

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journal = "Psychiatry and Clinical Neurosciences",

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AU - Paik, Jong Woo

AU - Lee, Heon Jeong

AU - Kang, Seong Gul

AU - Lim, Se Won

AU - Lee, Min Soo

AU - Kim, Leen

PY - 2007/2

Y1 - 2007/2

N2 - The present study tested the potential association between the 3111C/T polymorphism of the CLOCK gene and seasonal variations in mood and behavior. A total of 297 Korean college students were genotyped for the CLOCK polymorphism and the seasonal variation was evaluated using the Seasonal Pattern Assessment Questionnaire (SPAQ). The seasonality scores were not different between CLOCK gene variants (P > 0.05). Comparison between seasonals (syndromal plus subsyndromal seasonal affective disorder according to SPAQ) and non-seasonals found no significant difference in frequencies of genotypes (P > 0.05). These findings suggest that the CLOCK polymorphism does not play a major role in susceptibility to seasonal variations in a Korean population.

AB - The present study tested the potential association between the 3111C/T polymorphism of the CLOCK gene and seasonal variations in mood and behavior. A total of 297 Korean college students were genotyped for the CLOCK polymorphism and the seasonal variation was evaluated using the Seasonal Pattern Assessment Questionnaire (SPAQ). The seasonality scores were not different between CLOCK gene variants (P > 0.05). Comparison between seasonals (syndromal plus subsyndromal seasonal affective disorder according to SPAQ) and non-seasonals found no significant difference in frequencies of genotypes (P > 0.05). These findings suggest that the CLOCK polymorphism does not play a major role in susceptibility to seasonal variations in a Korean population.

KW - CLOCK

KW - Genetic association

KW - Polymorphism

KW - Seasonal affective disorder

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DO - 10.1111/j.1440-1819.2007.01621.x

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CLOCK gene 3111C/T polymorphism is not associated with seasonal variations in mood and behavior in Korean college students

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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