Clonal cell populations unresponsive to radiosensitization induced by telomerase inhibition

Yeun Jin Ju, Hyun Jin Shin, Jeong Eun Park, Kyoung Mi Juhn, Seon Rang Woo, Hee Young Kim, Young Hoon Han, Sang Gu Hwang, Sung Hee Hong, Chang Mo Kang, Young Do Yoo, Won Bong Park, Myung Haing Cho, Gil Hong Park, Kee Ho Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A combination of a radiotherapeutic regimen with telomerase inhibition is valuable when tumor cells are to be sensitized to radiation. Here, we describe cell clones unresponsive to radiosensitization after telomere shortening. After extensive division of individual transformed clones of mTERC-/- cells, about 22% of clones were unresponsive to radiosensitization even though telomerase action was inhibited. The telomere lengths of unsensitized mTERC-/- clones were reduced, as were those of most sensitized clones. However, the unsensitized clones did not exhibit chromosomal end-to-end fusion to the extent noted in all sensitized clones. Thus, a defense mechanism preventing telomere erosion is operative even when telomeres become shorter under conditions of telomerase deficiency, and results in unresponsiveness to the radiosensitization generally mediated by telomere shortening.

Original languageEnglish
Pages (from-to)198-202
Number of pages5
JournalBiochemical and biophysical research communications
Volume402
Issue number2
DOIs
Publication statusPublished - 2010 Nov 12

Keywords

  • Chromosomal end-to-end fusion
  • Radiosensitization
  • Telomere
  • Telomere length

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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