Cloning and Analysis of the Epstein-Barr Virus Glycoprotein 350 Genes

Sun Hwa Chang, Seon Hee Kim, Won Keun Lee, Hyun Ju Kim, Sang Hoon Choi, Joo Hung Park, Hyun Seok Jang, Gook Hyun Chung, Tae Ho Kwon, Dae Hyuk Kim, Moon Sik Yang, Yong Suk Jang

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Abstract

Membrane glycoprotein 350 (gp350) of the Epstein-Barr virus (EBV) is considered as a major target for vaccine development, since the gp350 has been identified as the virus' mediator for receptor interaction and as an inducer of specific in vitro virus-neutralizing antibodies. In an initial attempt to develop an effective DNA vaccine against an EBV infection, gp350 genes were isolated from SNU-20 and SNU-1103 which are the EBV-infected lymphoblastoid cell lines established in Korea. In addition, the nucleotide sequences of the gp350 genes were determined and compared with those of other EBV strains such as B95-8, P3HR-1/AG876 and M81. Sequence analysis showed that similar high degrees of homology between 2 EBV strains derived from African Burkitt's lymphoma, P3HR-1 and AG876, was shown between the gp350 genes isolated from 2 EBV-infected lymphoblastoid cell lines established in Korea. Furthermore, these 2 Korean and 2 African strains displayed nearly identical patterns of sequence variations from B95-8. In addition, the sequence of the isolated gp350 genes, which have been reported to be associated with the biology of EBV infection, is analyzed.

Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalMolecules and cells
Volume8
Issue number5
Publication statusPublished - 1998 Oct 31

Keywords

  • Epstein-Barr Virus
  • Glycoprotein 350
  • Vaccine

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Chang, S. H., Kim, S. H., Lee, W. K., Kim, H. J., Choi, S. H., Park, J. H., Jang, H. S., Chung, G. H., Kwon, T. H., Kim, D. H., Yang, M. S., & Jang, Y. S. (1998). Cloning and Analysis of the Epstein-Barr Virus Glycoprotein 350 Genes. Molecules and cells, 8(5), 585-593.