Clusterin enhances proliferation of primary astrocytes through extracellular signal-regulated kinase activation

Yong Jae Shin, Sang Wook Kang, Seong Yun Jeong, Young Jun Shim, Youn Hee Kim, Byeong Moo Kim, Sun-Ho Kee, Joong Jean Park, In Sun Park, Bon Hong Min

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Clusterin, a secretory glycoprotein, has been shown to be up-regulated in the reactive astrocytes in response to brain injury and neurodegenerative diseases, but its function has not been clearly elucidated. In this study, we investigate whether clusterin has growth-stimulatory activity in astrocytes. Suppression of clusterin with antisense oligonucleotide induced growth arrest, whereas transient overexpression of clusterin by cDNA transfection or exogenous treatment with purified clusterin promoted proliferation of the primary astrocytes in culture. This clusterin-stimulated proliferation was abrogated by PD98059, an inhibitor of mitogen-activated protein kinase kinase. These results suggest that clusterin might play an important role in astrogliosis by stimulating the proliferation of astrocytes through activation of the extracellular signal-regulated kinase 1/2 signaling pathway.

Original languageEnglish
Pages (from-to)1871-1875
Number of pages5
JournalNeuroReport
Volume17
Issue number18
DOIs
Publication statusPublished - 2006 Dec 1

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Keywords

  • Astrocyte
  • Astrogliosis
  • Clusterin
  • Extracellular signal-regulated kinase
  • Proliferation

ASJC Scopus subject areas

  • Neuroscience(all)

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