Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells

Yong Ryu Shi Yong Ryu, Youn Kou Na Youn Kou, Seok Choi Hong Seok Choi, H. Ryu, Tae Sung Kim, Man Kim Kyeong Man Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 μM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalPlanta Medica
Volume67
Issue number2
DOIs
Publication statusPublished - 2001 Apr 3
Externally publishedYes

Fingerprint

Angelica
coumarin
mast cells
Mast Cells
Inhibitory Concentration 50
inhibitory concentration 50
Apiaceae
beta-N-acetylhexosaminidase
Hexosaminidases
Coumarins
coumarins
cells
nitric oxide synthase
Nitric Oxide Synthase
cultured cells
nitric oxide
Cultured Cells
Nitric Oxide
extracts
dosage

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells. / Shi Yong Ryu, Yong Ryu; Na Youn Kou, Youn Kou; Hong Seok Choi, Seok Choi; Ryu, H.; Kim, Tae Sung; Kyeong Man Kim, Man Kim.

In: Planta Medica, Vol. 67, No. 2, 03.04.2001, p. 172-174.

Research output: Contribution to journalArticle

Shi Yong Ryu, Yong Ryu ; Na Youn Kou, Youn Kou ; Hong Seok Choi, Seok Choi ; Ryu, H. ; Kim, Tae Sung ; Kyeong Man Kim, Man Kim. / Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells. In: Planta Medica. 2001 ; Vol. 67, No. 2. pp. 172-174.
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abstract = "Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 μM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.",
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AU - Hong Seok Choi, Seok Choi

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AU - Kim, Tae Sung

AU - Kyeong Man Kim, Man Kim

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