Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells

Yong Ryu Shi Yong Ryu, Youn Kou Na Youn Kou, Seok Choi Hong Seok Choi, H. Ryu, Sung Kim Tae Sung Kim, Man Kim Kyeong Man Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 μM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.

Original languageEnglish
Pages (from-to)172-174
Number of pages3
JournalPlanta Medica
Volume67
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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