Codonopsis lanceolata extract prevents hypertension in rats

A. Young Han, Young Seok Lee, Soonho Kwon, Hui Su Lee, Kwang Won Lee, Geun Hee Seol

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Codonopsis lanceolata, a plant with antioxidant, anti-cancer, anti-inflammatory and blood lipid improving effects, has been widely used as a therapeutic agent in traditional medicine. Purpose The present study investigated the ability of an ethanol extract of Codonopsis lanceolata (ECL) to prevent hypertension in hypertensive rats. Methods Rats were orally administered daily doses of 0 mg/kg, 200 mg/kg and 400 mg/kg ECL for 3 weeks. As a positive control, rats were orally administered 10 mg/kg/day nifedipine. Hypertension was induced by immobilization stress for 2 h/day and by administration of 0.8 mg/kg/day nicotine for 3 weeks, followed by injection of 3 mg/kg nicotine on the day of sacrifice. Blood pressure and heart rate were measured using a volume pressure recording system. Vasoconstriction and vasodilation of aortic cross sections were measured with a physiological recorder. Neutrophil counts in bronchoalveolar lavage fluid were estimated with an automated cell counter. Results Treatment with both dosages of ECL significantly reduced systolic blood pressure (SBP) in hypertensive rats. Both doses of ECL tended to increase ACh- and SNP-induced vascular relaxation in hypertensive rats. Treatment with 200 mg/kg ECL significantly reduced neutrophil in hypertensive rats. Conclusions These results suggest that ECL is effective in reducing SBP and inflammation in hypertensive conditions.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalPhytomedicine
Volume39
DOIs
Publication statusPublished - 2018 Jan 15

Fingerprint

Codonopsis
Hypertension
Blood Pressure
Nicotine
Neutrophils
Bronchoalveolar Lavage Fluid
Traditional Medicine
Nifedipine
Vasoconstriction
Vasodilation
Immobilization
Single Nucleotide Polymorphism
Blood Vessels
Anti-Inflammatory Agents
Ethanol
Therapeutics
Antioxidants
Heart Rate
Inflammation
Lipids

Keywords

  • Anti-hypertension
  • Anti-inflammation
  • Codonopsis lanceolata

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Codonopsis lanceolata extract prevents hypertension in rats. / Han, A. Young; Lee, Young Seok; Kwon, Soonho; Lee, Hui Su; Lee, Kwang Won; Seol, Geun Hee.

In: Phytomedicine, Vol. 39, 15.01.2018, p. 119-124.

Research output: Contribution to journalArticle

Han, A. Young ; Lee, Young Seok ; Kwon, Soonho ; Lee, Hui Su ; Lee, Kwang Won ; Seol, Geun Hee. / Codonopsis lanceolata extract prevents hypertension in rats. In: Phytomedicine. 2018 ; Vol. 39. pp. 119-124.
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